174 research outputs found
Morphologic examination of the temporal bone by cone beam computed tomography: Comparison with multislice helical computed tomography
SummaryIntroductionHigh-resolution CT imaging is essential to diagnosis and follow-up of temporal bone pathology. Morphologically, CT is the reference examination. The requirement of long-term follow-up thus exposes patients to cumulative radiation doses. Limiting exposure to ionizing radiation is an increasing concern of public health authorities. The principal advantage of Cone Beam CT (CBCT) lies in a significant reduction in radiation dose. The main objective of the present study was to assess the morphologic concordance between CBCT and Multislice Helical Computed Tomography (MSCT) on 20 anatomic landmarks corresponding to regions of interest in clinical practice. The secondary objectives were to compare the two techniques qualitatively in stapes and footplate assessment and measurement of footplate thickness, and quantitatively in terms of dosimetry.Material and methodsAn experimental anatomical study was performed on 12 temporal bones from fresh human cadavers of unknown clinical history. Each underwent CBCT and MSCT.ResultsThere was no significant difference in morphologic assessment of the temporal bones on the two techniques. Exploration of the stapes, incudostapedial joint, anterior stapediovestibular joint and footplate was qualitatively more precise on CBCT, and footplate thickness showed less overestimation than on MSCT. CBCT delivered 22 times less radiation than MSCT under the present experimental conditions.ConclusionCBCT provides reliable morphologic assessment of temporal bone, thanks to higher spatial resolution than on MSCT, with significantly reduced radiation dose
Simulations of Solid-on-Solid Models of Spreading of Viscous Droplets
We have studied the dynamics of spreading of viscous non-volatile fluids on
surfaces by MC simulations of SOS models. We have concentrated on the complete
wetting regime, with surface diffusion barriers neglected for simplicity.
First, we have performed simulations for the standard SOS model. Formation of a
single precursor layer, and a density profile with a spherical cap shaped
center surrounded by Gaussian tails can be reproduced with this model.
Dynamical layering (DL), however, only occurs with a very strongly attractive
van der Waals type of substrate potential. To more realistically describe the
spreading of viscous liquid droplets, we introduce a modified SOS model. In the
new model, tendency for DL and the effect of the surface potential are in part
embedded into the dynamics of the model. This allows a relatively simple
description of the spreading under different conditions, with a temperature
like parameter which strongly influences the droplet morphologies. Both rounded
droplet shapes and DL can easily be reproduced with the model. Furthermore, the
precursor width increases proportional to the square root of time, in
accordance with experimental observations. PACS: 68.10.Gw, 05.70.Ln, 61.20.Ja.Comment: to appear in Physica A (1994), standard LaTex, 20 page
Angle of repose and segregation in cohesive granular matter
We study the effect of fluids on the angle of repose and the segregation of
granular matter poured into a silo. The experiments are conducted in two
regimes where: (i) the volume fraction of the fluid is small and it forms
liquid bridges between particles, and (ii) the particles are completely
immersed in the fluid. The data is obtained by imaging the pile formed inside a
quasi-two dimensional silo through the transparent glass side walls. In the
first series of experiments, the angle of repose is observed to increase
sharply with the volume fraction of the fluid and then saturates at a value
that depends on the size of the particles. We systematically study the effect
of viscosity by using water-glycerol mixtures to vary it over at least three
orders of magnitude while keeping the surface tension almost constant. Besides
surface tension, the viscosity of the fluid is observed to have an effect on
the angle of repose and the extent of segregation. In case of bidisperse
particles, segregation is observed to decrease and finally saturate depending
on the size ratio of the particles and the viscosity of the fluid. The sharp
initial change and the subsequent saturation in the extent of segregation and
angle of repose occurs over similar volume fraction of the fluid. In the second
series of experiments, particles are poured into a container filled with a
fluid. Although the angle of repose is observed to be unchanged, segregation is
observed to decrease with an increase in the viscosity of the fluid.Comment: 9 pages, 12 figure
Wet Granular Materials
Most studies on granular physics have focused on dry granular media, with no
liquids between the grains. However, in geology and many real world
applications (e.g., food processing, pharmaceuticals, ceramics, civil
engineering, constructions, and many industrial applications), liquid is
present between the grains. This produces inter-grain cohesion and drastically
modifies the mechanical properties of the granular media (e.g., the surface
angle can be larger than 90 degrees). Here we present a review of the
mechanical properties of wet granular media, with particular emphasis on the
effect of cohesion. We also list several open problems that might motivate
future studies in this exciting but mostly unexplored field.Comment: review article, accepted for publication in Advances in Physics;
tex-style change
Dragon-kings: mechanisms, statistical methods and empirical evidence
This introductory article presents the special Discussion and Debate volume
"From black swans to dragon-kings, is there life beyond power laws?" published
in Eur. Phys. J. Special Topics in May 2012. We summarize and put in
perspective the contributions into three main themes: (i) mechanisms for
dragon-kings, (ii) detection of dragon-kings and statistical tests and (iii)
empirical evidence in a large variety of natural and social systems. Overall,
we are pleased to witness significant advances both in the introduction and
clarification of underlying mechanisms and in the development of novel
efficient tests that demonstrate clear evidence for the presence of
dragon-kings in many systems. However, this positive view should be balanced by
the fact that this remains a very delicate and difficult field, if only due to
the scarcity of data as well as the extraordinary important implications with
respect to hazard assessment, risk control and predictability.Comment: 20 page
Photochromism and Electrochemistry of a Dithienylcyclopentene Electroactive Polymer
A bifunctional substituted dithienylcyclopentene photochromic switch bearing electropolymerisable methoxystyryl units, which enable immobilization of the photochromic unit on conducting substrates, is reported. The spectroscopic, electrochemical, and photochemical properties of a monomer in solution are compared with those of the polymer formed through oxidative electropolymerization. The electroactive polymer films prepared on gold, platinum, glassy carbon, and indium titanium oxide (ITO) electrodes were characterized by cyclic voltammetry, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The thickness of the films formed is found to be limited to several monolayer equivalents. The photochromic properties and stability of the polymer films have been investigated by UV/vis spectroscopy, electrochemistry, and XPS. Although the films are electrochemically and photochemically stable, their mechanical stability with respect to adhesion to the electrode was found to be sensitive to both the solvent and the electrode material employed, with more apolar solvents, glassy carbon, and ITO electrodes providing good adhesion of the polymer film. The polymer film is formed consistently as a thin film and can be switched both optically and electrochemically between the open and closed state of the photochromic dithienylethene moiety.
Evolution of an endofungal Lifestyle: Deductions from the Burkholderia rhizoxinica Genome
<p>Abstract</p> <p>Background</p> <p><it>Burkholderia rhizoxinica </it>is an intracellular symbiont of the phytopathogenic zygomycete <it>Rhizopus microsporus</it>, the causative agent of rice seedling blight. The endosymbiont produces the antimitotic macrolide rhizoxin for its host. It is vertically transmitted within vegetative spores and is essential for spore formation of the fungus. To shed light on the evolution and genetic potential of this model organism, we analysed the whole genome of <it>B. rhizoxinica </it>HKI 0454 - a type strain of endofungal <it>Burkholderia </it>species.</p> <p>Results</p> <p>The genome consists of a structurally conserved chromosome and two plasmids. Compared to free-living <it>Burkholderia </it>species, the genome is smaller in size and harbors less transcriptional regulator genes. Instead, we observed accumulation of transposons over the genome. Prediction of primary metabolic pathways and transporters suggests that endosymbionts consume host metabolites like citrate, but might deliver some amino acids and cofactors to the host. The rhizoxin biosynthesis gene cluster shows evolutionary traces of horizontal gene transfer. Furthermore, we analysed gene clusters coding for nonribosomal peptide synthetases (NRPS). Notably, <it>B. rhizoxinica </it>lacks common genes which are dedicated to quorum sensing systems, but is equipped with a large number of virulence-related factors and putative type III effectors.</p> <p>Conclusions</p> <p><it>B. rhizoxinica </it>is the first endofungal bacterium, whose genome has been sequenced. Here, we present models of evolution, metabolism and tools for host-symbiont interaction of the endofungal bacterium deduced from whole genome analyses. Genome size and structure suggest that <it>B. rhizoxinica </it>is in an early phase of adaptation to the intracellular lifestyle (genome in transition). By analysis of tranporters and metabolic pathways we predict how metabolites might be exchanged between the symbiont and its host. Gene clusters for biosynthesis of secondary metabolites represent novel targets for genomic mining of cryptic natural products. <it>In silico </it>analyses of virulence-associated genes, secreted proteins and effectors might inspire future studies on molecular mechanisms underlying bacterial-fungal interaction.</p
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