Das Grünland des Ökologischen Landbaus in Bayern Ergebnisse aus dem Grünlandmonitoring Bayern

The Bavarian Grasslandmonitoring (Bavarian grassland survey) included more than 6000 grassland sites of different farming intensities and geographical and climatic conditions in the first survey 2002-2008. Substantial information on species number and composition was provided in a high spatial resolution. To investigate the changes in vegetation, 2485 of the vegetation surveys were repeated between 2009 and 2012, 350 of them with organic farming. On each plot of 25 m² the species composition and the proportion of total yield of each species were documented. On average 20 species were recorded per 25 m² plot; a total number of 632 plant species was found all over the 2485 grassland plots. Comparing the first and the second survey the grassland vegetation showed only few changes in species composition on average. The mean species number per 25 m² plot remained at 20 species on average of all plots. Plots without any agri-environment scheme showed an average species number of 17 and the plots with organic farming a number of 21 at both repetitions. Thus, species number on organic grassland was clearly higher than on grassland without any schemes and slightly higher than the average

How Will Hydroelectric Power Generation Develop under Climate Change Scenarios?

Climate change has a large impact on water resources and thus on hydropower. Hydroelectric power generation is closely linked to the regional hydrological situation of a watershed and reacts sensitively to changes in water quantity and seasonality. The development of hydroelectric power generation in the Upper Danube basin was modelled for two future decades, namely 2021-2030 and 2051-2060, using a special hydropower module coupled with the physically-based hydrological model PROMET. To cover a possible range of uncertainties, 16 climate scenarios were taken as meteorological drivers which were defined from different ensemble outputs of a stochastic climate generator, based on the IPCC-SRES-A1B emission scenario and four regional climate trends. Depending on the trends, the results show a slight to severe decline in hydroelectric power generation. Whilst the mean summer values indicate a decrease, the mean winter values display an increase. To show past and future regional differences within the Upper Danube basin, three hydropower plants at individual locations were selected. Inter-annual differences originate predominately from unequal contributions of the runoff compartments rain, snow-and ice-melt

Der Einfluss der Fruchtfolge auf die Beikrautflora im ökologischen Landbau

Im ökologischen Landbau ist die Fruchtfolge ein wichtiges Element in der Unkrautregulierung. Fünf verschiedene Fruchtfolgevarianten wurden in einem Parzellenversuch in Oberbayern auf ihre Wirkung auf den Beikrautbesatz untersucht. Dafür wurde in den Jahren 2013-2016 die Beikrautvegetation (alle Arten und ihre Deckung) auf den Versuchsparzellen erfasst. Insgesamt wurden in den 120 Aufnahmen 93 Pflanzenarten registriert; im Mittel 26 Arten pro 40 m². Für die Kartoffeln ergab sich lediglich ein Unterschied in der Kulturdeckung, die in der Fruchtfolge mit Gülledüngung und zweijährigem Kleegras höher war als in den anderen beiden Kartoffel-Fruchtfolgen. Die Beikrautvegetation unterschied sich kaum zwischen den Fruchtfolgen. In der Sommer-Gerste konnte durch eine einjährige Kleegrasphase im Vergleich zur Ackerbohnenkultur die Beikrautdeckung geringer gehalten werden, u. a. durch einen geringeren Besatz mit Wurzelunkräutern wie Sonchus arvensis oder eine niedrigere Deckung von Avena fatua. Ähnliches zeigte sich auch im Winterweizen. Die Fruchtfolgevariante ohne Kartoffeln und Kleegras bot sowohl Wurzel- als auch Samenunkräutern eine bessere Etablierungschance, so dass auch die gesamte Wildkrautdeckung hier höher war

Exploring Snowfall Variability through the High-Latitude Measurement of Snowfall (HiLaMS) Field Campaign

The High-Latitude Measurement of Snowfall (HiLaMS) campaign explored variability in snowfall properties and processes at meteorologically distinct field sites located in Haukeliseter, Norway, and Kiruna, Sweden, during the winters of 2016/17 and 2017/18, respectively. Campaign activities were founded upon the sensitivities of a low-cost, core instrumentation suite consisting of Micro Rain Radar, Precipitation Imaging Package, and Multi-Angle Snow Camera. These instruments are highly portable to remote field sites and, considered together, provide a unique and complementary set of snowfall observations including snowflake habit, particle size distributions, fall speeds, surface snowfall accumulations, and vertical profiles of radar moments and snow water content. These snow-specific parameters, used in combination with existing observations from the field sites such as snow gauge accumulations and ambient weather conditions, allow for advanced studies of snowfall processes. HiLaMS observations were used to 1) successfully develop a combined radar and in situ microphysical property retrieval scheme to estimate both surface snowfall accumulation and the vertical profile of snow water content, 2) identify the predominant snowfall regimes at Haukeliseter and Kiruna and characterize associated macrophysical and microphysical properties, snowfall production, and meteorological conditions, and 3) identify biases in the HARMONIE-AROME numerical weather prediction model for forecasts of snowfall accumulations and vertical profiles of snow water content for the distinct snowfall regimes observed at the mountainous Haukeliseter site. HiLaMS activities and results suggest value in the deployment of this enhanced snow observing instrumentation suite to new and diverse high-latitude locations that may be underrepresented in climate and weather process studies.Exploring Snowfall Variability through the High-Latitude Measurement of Snowfall (HiLaMS) Field CampaignpublishedVersio

Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice

Excessive activation of cardiac fibroblasts (CFs) in response to injury provokes cardiac fibrosis, stiffness, and failure. The local mediators counter-regulating this response remain unclear. Exogenous C-type natriuretic peptide (CNP) exerted antifibrotic effects in preclinical models. To unravel the role of the endogenous hormone, we generated mice with fibroblast-restricted deletion (KO) of guanylyl cyclase-B (GC-B), the cGMP-synthesizing CNP receptor.CNP activated GC-B/cGMP signaling in human and murine CFs, preventing proliferative and promigratory effects of AngiotensinII (AngII) and TGF-β. Fibroblast-specific GC-B-KO mice showed enhanced fibrosis in response to AngII infusions. Moreover, after two weeks of mild pressure-overload induced by transverse aortic constriction (TAC), such KO mice had augmented cardiac fibrosis and hypertrophy, together with systolic and diastolic contractile dysfunction. This was associated with increased expression of the profibrotic genes collagen I, III and periostin. Notably, such responses to AngII and TAC were greater in female as compared to male KO mice. Enhanced AngII-induced CNP expression in female hearts and augmented GC-B expression and activity in female CFs may contribute to this sex disparity.The results show that paracrine CNP signaling in CFs has antifibrotic and antihypertrophic effects. The CNP/GC-B/cGMP pathway might be a target for therapies combating pathological cardiac remodeling

Fibin regulates cardiomyocyte hypertrophy and causes protein-aggregate-associated cardiomyopathy in vivo

Despite the identification of numerous molecular pathways modulating cardiac hypertrophy its pathogenesis is not completely understood. In this study we define an unexpected role for Fibin (“fin bud initiation factor homolog”) in cardiomyocyte hypertrophy. Via gene expression profiling in hypertrophic murine hearts after transverse aortic constriction we found a significant induction of Fibin. Moreover, Fibin was upregulated in another mouse model of cardiac hypertrophy (calcineurin-transgenics) as well as in patients with dilated cardiomyopathy. Immunoflourescence microscopy revealed subcellular localization of Fibin at the sarcomeric z-disc. Overexpression of Fibin in neonatal rat ventricular cardiomyocytes revealed a strong anti-hypertrophic effect through inhibiting both, NFAT- and SRF-dependent signalling. In contrast, transgenic mice with cardiac-restricted overexpression of Fibin developed dilated cardiomyopathy, accompanied by induction of hypertrophy-associated genes. Moreover, Fibin overexpression accelerated the progression to heart failure in the presence of prohypertrophic stimuli such as pressure overload and calcineurin overexpression. Histological and ultrastructural analyses surprisingly showed large protein aggregates containing Fibin. On the molecular level, aggregate formation was accompanied by an induction of the unfolded protein response subsequent UPR-mediated apoptosis and autophagy. Taken together, we identified Fibin as a novel potent negative regulator of cardiomyocyte hypertrophy in vitro. Yet, heart-specific Fibin overexpression in vivo causes development of a protein-aggregate-associated cardiomyopathy. Because of close similarities to myofibrillar myopathies, Fibin represents a candidate gene for cardiomyopathy and Fibin transgenic mice may provide additional mechanistic insight into aggregate formation in these diseases

The Priority position paper: protecting Europe's food chain from prions

International audienceBovine spongiform encephalopathy (BSE) created a global European crisis in the 1980s and 90s, with very serious health and economic implications. Classical BSE now appears to be under control, to a great extent as a result of a global research effort that identified the sources of prions in meat and bone meal (MBM) and developed new animal-testing tools that guided policy. Priority ( www.prionpriority.eu ) was a European Union (EU) Framework Program 7 (FP7)-funded project through which 21 European research institutions and small and medium enterprises (SMEs) joined efforts between 2009 and 2014, to conduct coordinated basic and applied research on prions and prion diseases. At the end of the project, the Priority consortium drafted a position paper ( www.prionpriority.eu/Priority position paper) with its main conclusions. In the present opinion paper, we summarize these conclusions. With respect to the issue of re-introducing ruminant protein into the feed-chain, our opinion is that sustaining an absolute ban on feeding ruminant protein to ruminants is essential. In particular, the spread and impact of non-classical forms of scrapie and BSE in ruminants is not fully understood and the risks cannot be estimated. Atypical prion agents will probably continue to represent the dominant form of prion diseases in the near future in Europe. Atypical L-type BSE has clear zoonotic potential, as demonstrated in experimental models. Similarly, there are now data indicating that the atypical scrapie agent can cross various species barriers. More epidemiological data from large cohorts are necessary to reach any conclusion on the impact of its transmissibility on public health. Re-evaluations of safety precautions may become necessary depending on the outcome of these studies. Intensified searching for molecular determinants of the species barrier is recommended, since this barrier is key for important policy areas and risk assessment. Understanding the structural basis for strains and the basis for adaptation of a strain to a new host will require continued fundamental research, also needed to understand mechanisms of prion transmission, replication and how they cause nervous system dysfunction and death. Early detection of prion infection, ideally at a preclinical stage, also remains crucial for development of effective treatment strategies