Prevention of Mother-to-child Transmission (PMTCT) of HIV in the Sub-Saharan Africa Region with a Focus on Uganda

With the rise of the HIV/AIDS epidemic in the past thirty years, people of all ages, infants to elderly alike, all over the world, suffer from its adverse effects. Even an unborn baby in-utero can contract this virulent infection by means of mother-to-child transmission (MTCT) (Sweeney, 2005). Infants and children diseased in this way comprise 90% of the estimated 800,000 new cases of HIV in children seen each year, but the region hit hardest, however, is Sub-Saharan Africa, with the country of Uganda historically having the highest incident rate for a time (Stringer, E.M., et al. 2008). Therefore, the purpose of this paper is to learn more about the prevention of MTCT in order to attain a better understanding of what is being done in this arena to impede HIV progression, to discover gaps in HIV/AIDS research and application, and to discern new and appropriate avenues in which a broader spectrum of people could contribute to the prevention of MTCT

Cuntz-Pimsner C*-algebras associated with subshifts

By using C*-correspondences and Cuntz-Pimsner algebras, we associate to every subshift (also called a shift space) $X$ a C*-algebra $O_X$, which is a generalization of the Cuntz-Krieger algebras. We show that $O_X$ is the universal C*-algebra generated by partial isometries satisfying relations given by $X$. We also show that $O_X$ is a one-sided conjugacy invariant of $X$.Comment: 28 pages. This is a slightly updated version of a preprint from 2004. Submitted for publication. In version 2 the Introduction has been changed, two remarks (Remark 7.6 and 7.7) have been added and the list of references has been update

Expansive homeomorphisms of the plane

This article tackles the problem of the classification of expansive homeomorphisms of the plane. Necessary and sufficient conditions for a homeomorphism to be conjugate to a linear hyperbolic automorphism will be presented. The techniques involve topological and metric aspects of the plane. The use of a Lyapunov metric function which defines the same topology as the one induced by the usual metric but that, in general, is not equivalent to it is an example of such techniques. The discovery of a hypothesis about the behavior of Lyapunov functions at infinity allows us to generalize some results that are valid in the compact context. Additional local properties allow us to obtain another classification theorem.Comment: 29 pages, 22 figure

The Internet as a Speech Machine and Other Myths Confounding Section 230 Reform

A robust public debate is currently underway about the responsibility of online platforms. We have long called for this discussion, but only recently has it been seriously taken up by legislators and the public. The debate begins with a basic question: should platforms should be responsible for user-generated content? If so, under what circumstances? What exactly would such responsibility look like? Under consideration is Section 230 of the Communications Decency Act—a provision originally designed to encourage tech companies to clean up “offensive” online content. The public discourse around Section 230, however, is riddled with misconceptions. As an initial matter, many people who opine about the law are unfamiliar with its history, text, and application. This lack of knowledge impairs thoughtful evaluation of the law’s goals and how well they have been achieved. Accordingly, Part I of this Article sets the stage with a description of Section 230—its legislative history and purpose, its interpretation in the courts, and the problems that current judicial interpretation raises. A second, and related, major source of misunderstanding is the conflation of Section 230 and the First Amendment. Part II details how this conflation distorts discussion in three ways: it assumes all Internet activity is protected speech; it treats private actors as though they were government actors; and it presumes that regulation will inevitably result in less speech. These distortions must be addressed in order to pave the way for clear-eyed policy reform. Part III offers potential solutions to help Section 230 achieve its legitimate goals

Criminalizing Revenge Porn

Violations of sexual privacy, notably the non-consensual publication of sexually graphic images in violation of someone\u27s trust, deserve criminal punishment. They deny subjects\u27 ability to decide if and when they are sexually exposed to the public and undermine trust needed for intimate relationships. Then too they produce grave emotional and dignitary harms, exact steep financial costs, and increase the risks of physical assault. A narrowly and carefully crafted criminal statute can comport with the First Amendment. The criminalization of revenge porn is necessary to protect against devastating privacy invasions that chill self-expression and ruin lives

Cultural Awareness Training: Preparing New Instructors for the Millennial Student

It is not unusual for instructors to face challenges relating to, understanding, or motivating their students. Educators can chalk this up to a variety of factors, including differences in and between education levels, life experiences, and ascribed power roles. We argue, however, that it is the generational differences between instructors and their students that pose a much greater challenge toward the establishment of a productive teacher-student relationship and the facilitation of learning. With the age of the Millennial college student upon us, we make the case that the most important area of training for new instructors is developing cultural awareness about the Millennial generation. As McGlynn (2005) said, “facilitating learning involves understanding who our students are” (p. 12). As such, we believe it is essential for new, and seasoned, instructors to learn about the social, cultural and environmental factors that shape the Millennial learner (Roberts, Newman, & Schwartzstein, 2012). In the following pages, we hope to inspire cultural curiosity through highlighting Millennial characteristics and recommending tools for developing cultural awareness in new college instructors

SYSTEMS-2: a randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma

SYSTEMS-2 is a randomised study of radiotherapy dose escalation for pain control in 112 patients with malignant pleural mesothelioma (MPM). Standard palliative (20Gy/5#) or dose escalated treatment (36Gy/6#) will be delivered using advanced radiotherapy techniques and pain responses will be compared at week 5. Data will guide optimal palliative radiotherapy in MPM

An automatic visual analysis system for tennis

This article presents a novel video analysis system for coaching tennis players of all levels, which uses computer vision algorithms to automatically edit and index tennis videos into meaningful annotations. Existing tennis coaching software lacks the ability to automatically index a tennis match into key events, and therefore, a coach who uses existing software is burdened with time-consuming manual video editing. This work aims to explore the effectiveness of a system to automatically detect tennis events. A secondary aim of this work is to explore the bene- fits coaches experience in using an event retrieval system to retrieve the automatically indexed events. It was found that automatic event detection can significantly improve the experience of using video feedback as part of an instructional coaching session. In addition to the automatic detection of key tennis events, player and ball movements are automati- cally tracked throughout an entire match and this wealth of data allows users to find interesting patterns in play. Player and ball movement information are integrated with the automatically detected tennis events, and coaches can query the data to retrieve relevant key points during a match or analyse player patterns that need attention. This coaching software system allows coaches to build advanced queries, which cannot be facilitated with existing video coaching solutions, without tedious manual indexing. This article proves that the event detection algorithms in this work can detect the main events in tennis with an average precision and recall of 0.84 and 0.86, respectively, and can typically eliminate man- ual indexing of key tennis events

Statistical modeling of biomedical corpora: mining the Caenorhabditis Genetic Center Bibliography for genes related to life span

BACKGROUND: The statistical modeling of biomedical corpora could yield integrated, coarse-to-fine views of biological phenomena that complement discoveries made from analysis of molecular sequence and profiling data. Here, the potential of such modeling is demonstrated by examining the 5,225 free-text items in the Caenorhabditis Genetic Center (CGC) Bibliography using techniques from statistical information retrieval. Items in the CGC biomedical text corpus were modeled using the Latent Dirichlet Allocation (LDA) model. LDA is a hierarchical Bayesian model which represents a document as a random mixture over latent topics; each topic is characterized by a distribution over words. RESULTS: An LDA model estimated from CGC items had better predictive performance than two standard models (unigram and mixture of unigrams) trained using the same data. To illustrate the practical utility of LDA models of biomedical corpora, a trained CGC LDA model was used for a retrospective study of nematode genes known to be associated with life span modification. Corpus-, document-, and word-level LDA parameters were combined with terms from the Gene Ontology to enhance the explanatory value of the CGC LDA model, and to suggest additional candidates for age-related genes. A novel, pairwise document similarity measure based on the posterior distribution on the topic simplex was formulated and used to search the CGC database for "homologs" of a "query" document discussing the life span-modifying clk-2 gene. Inspection of these document homologs enabled and facilitated the production of hypotheses about the function and role of clk-2. CONCLUSION: Like other graphical models for genetic, genomic and other types of biological data, LDA provides a method for extracting unanticipated insights and generating predictions amenable to subsequent experimental validation

Onset and Heterogeneity of Responsiveness to FSH in Mouse Preantral Follicles in Culture

The obligatory role of follicle-stimulating hormone (FSH) in normal development and function of ovarian antral follicles is well recognized, but its function in preantral growth is less clear. The specific objective of this study was to investigate the response, in culture, to FSH of mouse preantral follicles of increasing size, focusing particularly on growth rate and gene expression. Preantral follicles were mechanically isolated from ovaries of C57BL/6 mice, 12 to 16 days postpartum, and single follicles cultured for up to 96 hours in medium alone (n = 511) or with recombinant human FSH 10 ng/mL (n = 546). Data were grouped according to initial follicle diameter in 6 strata ranging from ,100 to .140 mm. Follicles of all sizes grew in the absence of FSH (P , 0.01, paired t test). All follicles grew at a faster rate (P , 0.0001) in the presence of 10 ng/mL FSH but larger follicles showed the greatest change in response to FSH. Even the smallest follicles expressed FSH receptor messenger RNA (mRNA). FSH-induced growth was inhibited by KT5720, an inhibitor of protein kinase A (PKA), implicating the PKA pathway in FSH-induced follicle growth. In response to FSH in vitro, FSH receptor mRNA (measured by quantitative polymerase chain reaction) was reduced (P , 0.01), as was Amh (P , 0.01), whereas expression of StAR (P , 0.0001) and the steroidogenic enzymes Cyp11a1 (P , 0.01) and Cyp19 (P , 0.0001) was increased. These results show heterogeneous responses to FSH according to initial follicle size, smaller follicles being less FSH dependent than larger preantral follicles. These findings strongly suggest that FSH has a physiological role in preantral follicle growth and function