MKBA Peilverandering Polder Zegveld

Het Westelijk Veenweidegebied is al eeuwenlang onderhevig aan bodemdaling en oxidatie van het veen. Een mogelijkheid om dit tegen te gaan is het veranderen c.q. verhogen van het peil van het oppervlaktewater. Peilverandering zal naar verwachting tal van effecten hebben voor de regio. Naast effecten voor de reguliere landbouw en het waterbeheer kan peilverandering ook invloed hebben op de natuurwaarden in het gebied, het woongenot en de inkomsten van recreatie-afhankelijke sectoren. In dit rapport wordt met behulp van het instrument Maatschappelijke Kosten Baten Analyse (MKBA) bezien welke kosten en baten peilverandering in de polder Zegveld met zich meebrengt

Effect of silt, water and periphyton quality on survival and growth of the mayfly Heptagenia sulphurea

The herbivorous mayfly Heptagenia sulphurea is characteristic of rivers with stony bottoms. Records from the 20th century showed that this species had disappeared from the Common Meuse in the Netherlands, probably due to river regulation or changes in water quality. A field survey in 2003 showed that H. sulphurea was present in the Geul tributary, approximately 300 m upstream of its confluence with the Common Meuse. H. sulphurea has not recolonized the Common Meuse despite improvements in water quality over the last decades. Concentration of suspended sediments in the River Meuse, however, is still high, much higher than in the beginning of the 20th century. The presence of a silt layer may limit the return of H. sulphurea in this river by reducing availability and quality of its food. The prime objective of this study was to investigate the impact of silt on survival and growth of H. sulphurea in a laboratory experiment. Furthermore, the impact of water and periphyton quality from the Common Meuse on survival and growth of this mayfly was also investigated. Results showed that neither water quality nor cultured periphyton from the Common Meuse reduced survival and growth of H. sulphurea. The presence of a silt layer resulted in a significantly lower growth rate of the mayfly larvae. It is concluded that the silt layer reduces the accessibility of the food. Covering of food is possibly one of the main factors limiting the recolonization of H. sulphurea and probably other benthic grazers in the Common Meuse

PO-0891: Clinical implementation and experience with real-time anatomy tracking and gating during MR-IGRT

Cardiolog

Achtergronddocument referenties en maatlatten voor macrofauna

Voor de implementatie van de KRW Water (KRW) in Nederland is een regionale ambtelijke en bestuurlijke overlegstructuur in het leven geroepen en zijn verschillende productteams geformeerd. Een van de taken van de productnaam is het beschrijven van de referentietoestand van de verschillende typen waterlichamen. Deze beschrijving moet eind 2004 gereed zijn. De nationale interdepartementale werkgroep Doelstellingen Oppervlaktewater en de STOWA ondersteunen deze taak door een deel van het instrumentarium centraal te ontwikkelen, namelijk de ecologische beoordeling van oppervlaktewateren. Voor het uitwerken van de beoordeling van de biologische kwaliteitselementen zijn vier expertgroepen geformeerd: 1) fytoplankton, microfytobenthos en macrofyten 2) angiospermen en macroalgen 3) macrofauna 4) vissen Dit achtergronddocument gaat in op de beoordeling van macrofauna, die is gebaseerd op een beoordeling van de soortensamenstelling. De soortensamenstelling is opgesplitst in drie groepen van indicatoren (parameters) namelijk dominante, indicatieve/kenmerkende en zeldzame taxa. In dit rapport wordt ingegaan op de achterliggende keuzes, specificaties en onderbouwing van de parameter

Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?

Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic features, apoptosis, the expr

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg(2+) reabsorption. Here, we used a Cnnm2 knock out mouse model, generated by CRISPR/Cas9 technology, to assess the role of CNNM2 in Mg(2+) homeostasis. Breeding Cnnm2(+/-) mice resulted in a Mendelian distribution at embryonic day 18. Nevertheless, only four Cnnm2(-/-) pups were born alive. The Cnnm2(-/-) pups had a significantly lower serum Mg(2+) concentration compared to wildtype littermates. Subsequently, adult Cnnm2(+/-) mice were fed with low, control, or high Mg(2+) diets for two weeks. Adult Cnnm2(+/-) mice showed mild hypomagnesaemia compared to Cnnm2(+/+) mice and increased serum Ca(2+) levels, independent of dietary Mg(2+) intake. Faecal analysis displayed increased Mg(2+) and Ca(2+) excretion in the Cnnm2(+/-) mice. Transcriptional profiling of Trpm6, Trpm7, and Slc41a1 in kidneys and colon did not reveal effects based on genotype. Microcomputed tomography analysis of the femurs demonstrated equal bone morphology and density. In conclusion, CNNM2 is vital for embryonic development and Mg(2+) homeostasis. Our data suggest a previously undescribed role of CNNM2 in the intestine, which may contribute to the Mg(2+) deficiency in mice and patients

Referenties en maatlatten voor natuurlijke watertypen voor de kaderrichtlijn water 2015-2021

Dit rapport is een geactualiseerde versie van ‘Referenties en maatlatten voor natuurlijke watertypen voor de Kaderrichtlijn Water’. Het is het resultaat van een evaluatie van de maatlatten in de aanloop naar de tweede generatie Stroomgebiedbeheerplannen (2015-2021) en van een harmonisatie met de beoordelingsmethoden in het buitenland. Deze versie dient te worden gebruikt voor de doelafleiding en toestandsbepaling voor deze tweede generatie. De aanpassingen zijn voorbereid door teams van technisch specialisten en afgestemd binnen de werkgroep Ecologische Maatlatten, met vertegenwoordigers van waterschappen, provincies, het Ministerie van I&M en de STOWA. De aanpassing van de vissenmaatlat is afgestemd met Sportvisserij Nederland

Structural brain differences in pre-adolescents who persist in and recover from stuttering

Background: Stuttering is a complex speech fluency disorder occurring in childhood. In young children, stuttering has been associated with speech-related auditory and motor areas of the brain. During transition into adolescence, the majority of children who stutter (75–80%) will experience remission of their symptoms. The current study evaluated brain (micro-)structural differences between pre-adolescents who persisted in stuttering, those who recovered, and fluently speaking controls. Methods: This study was embedded in the Generation R Study, a population-based cohort in the Netherlands of children followed from pregnancy onwards. Neuroimaging was performed in 2211 children (mean age: 10 years, range 8–12), of whom 20 persisted in and 77 recovered from stuttering. Brain structure (e.g., gray matter) and microstructure (e.g., diffusion tensor imaging) differences between groups were tested using multiple linear regression. Results: Pre-adolescents who persisted in stuttering had marginally lower left superior frontal gray matter volume compared to those with no history of stuttering (β −1344, 95%CI −2407;-280), and those who recovered (β −1825, 95%CI −2999;-650). Pre-adolescents who recovered, compared to those with no history of stuttering, had higher mean diffusivity in the forceps major (β 0.002, 95%CI 0.001;0.004), bilateral superior longitudinal fasciculi (β 0.001, 95%CI 0.000;0.001), left corticospinal tract (β 0.003, 95%CI 0.002;0.004), and right inferior longitudinal fasciculus (β 0.001, 95%CI 0.000;0.001). Conclusion: Findings suggest that relatively small difference in prefrontal gray matter volume is associated with persistent stuttering, and alterations in white matter tracts are apparent in individuals who recovered. The findings further strengthen the potential relevance of brain (micro-)structure in persistence and recovery from stuttering in pre-adolescents