Graphic design & ubiquitous graphic user interfaces; The Third Wave of Computing

Graphic design is an integral component of user interface design. Ubiquitous computing is the a form of computing that is everywhere all the time through technology advances in hardware, software, and communication networks. Consumers are able to retrieve and send information whenever a task needs to be completed. Graphic design is part of the visual mechanism through which people interact with devices. The visual interactive components of these devices are the part of computing systems that are addressed in this project. This thesis addresses the problems that arise when people need to interact with several devices at a given time. The goal is to make the experience of an imaging appliance as enjoyable and useful as possible. Graphic design is the key component in the visual communication aspect of these devices. The ideas used in the scenarios that are described in the ideation stage assume that future technologies are mainstream and used by the mass consumer. Although these assumptions may or may not come to fruition, graphic design will still be a integral part of that user experience

Quantification of Nematic Cell Polarity in Three-dimensional Tissues

How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polarity in simple, sheet-like epithelia. We propose a conceptual and algorithmic framework to characterize complex patterns of polarity proteins on the surface of a cell in terms of a multipole expansion. To rigorously quantify previously observed tissue-level patterns of nematic cell polarity (Morales-Navarette et al., eLife 8:e44860, 2019), we introduce the concept of co-orientational order parameters, which generalize the known biaxial order parameters of the theory of liquid crystals. Applying these concepts to three-dimensional reconstructions of single cells from high-resolution imaging data of mouse liver tissue, we show that the axes of nematic cell polarity of hepatocytes exhibit local coordination and are aligned with the biaxially anisotropic sinusoidal network for blood transport. Our study characterizes liver tissue as a biological example of a biaxial liquid crystal. The general methodology developed here could be applied to other tissues or in-vitro organoids.Comment: 27 pages, 9 color figure

Cerebral Responses To Innocuous Somatic Pressure Stimulation Following Aerobic Exercise Rehabilitation In Chronic Pain Patients: A Functional Magnetic Resonance Imaging Study

The purpose of this research was to assess the functional brain activity and perceptual rating of innocuous somatic pressure stimulation before and after exercise rehabilitation in patients with chronic pain

Magnetic Tilting in Nematic Liquid Crystals Driven by Self‐Assembly

Self-assembly is one of the crucial mechanisms allowing the design multifunctional materials. Soft hybrid materials contain components of different natures and exhibit competitive interactions which drive self-organization into structures of a particular function. Here a novel type of a magnetic hybrid material where the molecular tilt can be manipulated through a delicate balance between the topologically-assisted colloidal self-assembly of magnetic nanoparticles and the anisotropic molecular interactions in a liquid crystal matrix is demonstrated

Peeking beneath the precision floor I: metallicity spreads and multiple elemental dispersions in the globular clusters NGC 288 and NGC 362

The view of globular clusters (GCs) as simple systems continues to unravel, revealing complex objects hosting multiple chemical peculiarities. Using differential abundance analysis, we probe the chemistry of the Type I GC, NGC 288 and the Type II GC, NGC 362 at the 2\% level for the first time. We measure 20 elements and find differential measurement uncertainties on the order 0.01-0.02 dex in both clusters. The smallest uncertainties are measured for Fe I in both clusters, with an average uncertainty of $\sim$0.013 dex. Dispersion in the abundances of Na, Al, Ti I, Ni, Fe I, Y, Zr, Ba and Nd are recovered in NGC 288, none of which can be explained by a spread in He. This is the first time, to our knowledge, a statistically significant spread in $s$-process elements and a potential spread in metallicity has been detected in NGC 288. In NGC 362, we find significant dispersion in the same elements as NGC 288, with the addition of Co, Cu, Zn, Sr, La, Ce, and Eu. Two distinct groups are recovered in NGC 362, separated by 0.3 dex in average differential $s$-process abundances. Given strong correlations between Al and several $s$-process elements, and a significant correlation between Mg and Si, we propose that the $s$-process rich group is younger. This agrees with asymptotic giant branch star (AGB) enrichment between generations, if there is overlap between low- and intermediate-mass AGBs. In our scenario, the older population is dominated by the $r$-process with a $\Delta^{\mathrm{La}}-\Delta^{\mathrm{Eu}}$ ratio of $-0.16\pm0.06$. We propose that the $r$-process dominance and dispersion found in NGC 362 are primordial.Comment: First paper in a series. Accepted for publication in MNRA

Generating Bijections between HOAS and the Natural Numbers

A provably correct bijection between higher-order abstract syntax (HOAS) and the natural numbers enables one to define a "not equals" relationship between terms and also to have an adequate encoding of sets of terms, and maps from one term family to another. Sets and maps are useful in many situations and are preferably provided in a library of some sort. I have released a map and set library for use with Twelf which can be used with any type for which a bijection to the natural numbers exists. Since creating such bijections is tedious and error-prone, I have created a "bijection generator" that generates such bijections automatically together with proofs of correctness, all in the context of Twelf.Comment: In Proceedings LFMTP 2010, arXiv:1009.218

Completely steroid-free immunosuppression in liver transplantation: a randomized study.

INTRODUCTION: Corticosteroids (CS) have been standard immunosuppression to prevent and treat rejection. However, CS are associated with increased risk of infection, obesity, hypertension, hyperlipidemia, diabetes, and accelerated hepatitis C virus (HCV) recurrence post-orthotopic liver transplantation (OLT). This study assesses the safety and efficacy of CS-free immunosuppressive regimen in adult OLT. METHODS: A two-yr, prospective, randomized study of CS with delayed withdrawal (CS) or CS-free regimen with basiliximab, tacrolimus, and enteric-coated mycophenolate sodium (EC-MPS) was performed in 39 patients (CS=20; CS-free=19). CS group received intra-operative methylprednisolone weaned by six months. HCV patients had HCV PCR pre-OLT and 0.5, one, three, and six months post-OLT. Protocol liver biopsies were performed at OLT, 2 and 24 wk post-OLT or when indicated. RESULTS: Rejection occurred in two patients. Patient survival at one yr (100% vs. 95%), three yr (85% vs. 63%), and five yr (80% vs. 63%) post-OLT were similar between CS and CS-free group, respectively. Death-censored graft survival at one yr (100% vs. 95%), three yr (85% vs. 63%), and five yr (75% vs. 63%) were also similar. The risk of new-onset DM, hypertension, hypercholesterolemia, and weight gain was similar between groups. CONCLUSION: CS avoidance with basiliximab, calcineurin inhibitor, and EC-MPS is safe and effective as CS- containing immunosuppression in adult OLT

Phenotypic and genetic associations between reading comprehension, decoding skills, and ADHD dimensions : evidence from two population-based studies

BACKGROUND: The phenotypic and genetic associations between decoding skills and ADHD dimensions have been documented but less is known about the association with reading comprehension. The aim of the study is to document the phenotypic and genetic associations between reading comprehension and ADHD dimensions of inattention and hyperactivity/impulsivity in early schooling and compare them to those with decoding skills. METHODS: Data were collected in two population-based samples of twins (Quebec Newborn Twin Study - QNTS) and singletons (Quebec Longitudinal Study of Child Development - QLSCD) totaling ≈ 2300 children. Reading was assessed with normed measures in second or third grade. Teachers assessed ADHD dimensions in kindergarten and first grade. RESULTS: Both decoding and reading comprehension were correlated with ADHD dimensions in a similar way: associations with inattention remained after controlling for the other ADHD dimension, behavior disorder symptoms and nonverbal abilities, whereas associations with hyperactivity/impulsivity did not. Genetic modeling showed that decoding and comprehension largely shared the same genetic etiology at this age and that their associations with inattention were mostly explained by shared genetic influences. CONCLUSION: Both reading comprehension and decoding are uniquely associated with inattention through a shared genetic etiology