Are Ceramide Containing Creams A Safe And Effective Treatment For Patients With Atopic Dermatitis?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not ceramide containing creams are a safe and effective treatment for patients with atopic dermatitis. STUDY DESIGN: Review of three randomized controlled studies published in English between 2009-2016. DATA SOURCES: Three assessor blind randomized controlled trials found using PubMed and EbscoHOST databases. OUTCOMES MEASURED: Each of the three trials assessed safety and efficacy of a ceramide containing cream compared with another method in the treatment of atopic dermatitis. Outcomes were measured by Eczema Severity Score (ESS), rating of skin dryness on a 0-4 scale, transepidermal water loss (TEWL) measurements, and Severity Scoring for Atopic Dermatitis (SCORAD) on a scale of 0-72. RESULTS: The Marseglia et al1 study showed that subjects using the ceramide containing cream had an 84% reduction in their Eczema Severity Score (ESS), compared to the subjects using the simple hydrating cream who had a 50% reduction in the ESS. This difference was statistically significant as p=0.0001. The Simpson et al2 study showed statistically significant improvements in skin dryness, skin hydration and transepidermal water loss (TEWL) in the cream with a ceramide precursor as compared to no treatment. The Sugarman et al3 study showed a 50.7% decrease (

Theory-based communication skills training for medicine counter assistants to improve consultations for non-prescription medicines

Context: Medicine counter assistants (MCAs) supply the majority of non-prescription medicines (NPMs) to consumers. Suboptimal communication during consultations between consumers and MCAs has been identified as a major cause of inappropriate supply. Evidence from medical consultations suggests that training in specified communication skills can change professional behaviour. Methods: A feasibility study was conducted to evaluate the effect of theory-based communication skills training for MCAs. Thirty MCAs were recruited from 21 community pharmacies in Grampian, Scotland. The intervention comprised 2 4-hour training sessions, held 1 month apart. The sessions were informed by results from previous studies and the Calgary−Cambridge evidence-based model of communication skills training. Strategies for guiding individuals through change were adopted from cognitive behavioural therapy techniques. The theory of planned behaviour was used to assess potential pathways to behaviour change. Recorded data were collected during covert visits to the pharmacies by simulated patients at baseline and 1 month after each training session. Communication performance was measured as the number and type of questions asked. Results: Compared with baseline measures, the total number of questions asked increased in the intervention group at both timepoints. No change was shown in the control group between baseline and follow-up 1, and a decrease was shown in the total number of questions from follow-up 1 to 2. The intervention appeared to have greater effect on consultations involving advice, compared with those concerning product requests. Discussion: Communication performance improved following training. Increased information exchange is associated with guideline-compliant supply of NPMs. A substantive randomised, controlled trial is now planned to assess the intervention.This study was funded by the Chief Scientist Office, Scottish Executive Health Department

Rainfall seasonality captured in micromammalian fauna in Late Quaternary contexts, South Africa

There exists ongoing debate regarding shifts in the latitudinal extent of the southern African winter-rainfall zone throughout the late Quaternary. Fossil proxies which can be related directly to rainfall seasonality have the potential to assist in quantifying these shifts. Relationships between mean monthly temperature and mean monthly rainfall in modern environments are quantified to generate a seasonality index associated with summer- or winter-rainfall. These seasonality indices can in turn be related to percentage occurrences reflecting relative abundances of rodent taxa represented in areas within southern Africa. Such data are used together to obtain an equation from which an index of seasonality in rainfall can be calculated, based on relative abundances of rodents in the modern landscape. The equation is applied to rodents represented in a Late Quaternary faunal sequence at Boomplaas Cave in the south-eastern part of the Western Cape Province. Results confirm that this region experienced a predominantly winter-rainfall regime during the Last Glacial Maximum (LGM), though the amount of rain may have been relatively low for the coldest episodes circa 20,000 cal. yr BP in the Boomplaas palaeo-environments.National Research Foundation, Andrew Mellon Foundatio

Rainfall seasonality captured in micromammalian fauna in Late Quaternary contexts, South Africa

There exists ongoing debate regarding shifts in the latitudinal extent of the southern African winter-rainfall zone throughout the late Quaternary. Fossil proxies which can be related directly to rainfall seasonality have the potential to assist in quantifying these shifts. Relationships between mean monthly temperature and mean monthly rainfall in modern environments are quantified to generate a seasonality index associated with summer- or winter-rainfall. These seasonality indices can in turn be related to percentage occurrences reflecting relative abundances of rodent taxa represented in areas within southern Africa. Such data are used together to obtain an equation from which an index of seasonality in rainfall can be calculated, based on relative abundances of rodents in the modern landscape. The equation is applied to rodents represented in a Late Quaternary faunal sequence at Boomplaas Cave in the south-eastern part of the Western Cape Province. Results confirm that this region experienced a predominantly winter-rainfall regime during the Last Glacial Maximum (LGM), though the amount of rain may have been relatively low for the coldest episodes circa 20,000 cal. yr BP in the Boomplaas palaeo-environments.National Research Foundation, Andrew Mellon Foundatio

Determining Annoyance Thresholds of Tones in Noise

Building services equipment often produces noise signatures with significant tones in them that can lead to complaints in the built environment. Previous studies have investigated prominence levels of assorted tonal frequencies, but it is still unclear what prominence of the tones across varying tonal frequencies can lead to human annoyance. This project seeks to apply two different methods towards defining annoyance thresholds of tones in noise at two tonal frequencies: 125 Hz and 500 Hz. In the first, subjects are asked to perform a task, while exposed to ten minutes of a broadband noise spectrum with a specific level of tonal prominence. They are subsequently asked to rate their annoyance to that noise condition. Five prominence levels of each of the two tones are tested above two different background noise levels, for a total of 20 test trials. In the second methodology, subjects listen to each of the two tonal frequencies at a predetermined level above each of the two background noise levels, and then adjust the level of the tone up or down until it becomes just annoying. The strengths, weaknesses, and results obtained for the annoyance thresholds of tones in noise from each of these methods are compared

The Oxidation State of Sulfur in Lunar Apatite

Lunar apatites contain hundreds to thousands of parts per million of sulfur. This is puzzling because lunar basalts are thought to form in low oxygen fugacity (f(sub O2)) conditions where sulfur can only exist in its reduced form (S2()), a substitution not previously observed in natural apatite. We present measurements of the oxidation state of S in lunar apatites and associated mesostasis glass that show that lunar apatites and glass contain dominantly S2(), whereas natural apatites from Earth are only known to contain S6+. It is likely that many terrestrial and martian igneous rocks contain apatites with mixed sulfur oxidation states. The S6(+)/S2() ratios of such apatites could be used to quantify the f(sub O2) values at which they crystallized, given information on the portioning of S6(+) and S2() between apatite and melt and on the S6(+)/S2() ratios of melts as functions of f(sub O2) and melt composition. Such a well-calibrated oxybarometer based on this the oxidation state of S in apatite would have wide application

Young people's attitudes to religious diversity : quantitative approaches from social psychology and empirical theology

This essay discusses the design of the quantitative component of the ‘Young People’s Attitudes to Religious Diversity’ project, conceived by Professor Robert Jackson within the Warwick Religions and Education Research Unit, and presents some preliminary findings from the data. The quantitative component followed and built on the qualitative component within a mixed method design. The argument is advanced in seven steps: introducing the major sources of theory on which the quantitative approach builds from the psychology of religion and from empirical theology; locating the empirical traditions of research among young people that have shaped the study; clarifying the notions and levels of measurement employed in the study anticipating the potential for various forms of data analysis; discussing some of the established measures incorporated in the survey; defining the ways in which the sample was structured to reflect the four nations of the UK, and London; illustrating the potential within largely descriptive cross-tabulation forms of analysis; and illustrating the potential within more sophisticated multivariate analytic models

Are different reading problems associated with different anxiety types?

There is a reliable association between poor reading and anxiety, but we do not completely understand the specifics of this relationship. The current study included a sample of children (N = 284; Mage = 9.30, SDage = 1.31) who completed a reading (word, nonword, and text reading accuracy, word, nonword, and text reading fluency, passage reading comprehension) and anxiety (social anxiety, generalized anxiety, separation anxiety, physical injury fears/phobias, panic, obsessive compulsive symptoms) assessment. Analyses included bivariate and partial correlations, principal components analysis, and hierarchical clustering. We found a very tentative suggestion in the data that there may be a specific yet weak association between reading accuracy and social anxiety. The clinical implications and directions for future research are discussed

Impact of Tobacco-Pack Pictorial Warnings on Youth and Young adults: A Systematic Review of Experimental Studies

Introduction:We conducted a systematic review of the experimental literature on the impact of tobacco-pack pictorial warning labels (PWLs) on youth and young adults. Methods:We systematically searched computerized databases and the reference list of relevant articles. We included studies that used an experimental protocol to assess PWLs. Studies had to report findings for youth or young adult samples (aged \u3c 30 years). Thirty-one studies met the inclusion criteria, with a total sample size of 27506. Two coders independently coded all study characteristics and outcomes. Results:Twenty-eight studies experimentally evaluated PWLs for cigarette packs while three studies evaluated PWLs for smokeless tobacco packs. Generally, PWLs led to higher attention, stronger cognitive and affective reactions, more negative pack attitudes and smoking attitudes, and increased intentions not to use tobacco products compared to text warnings. PWLs were perceived to be more effective than text warnings for both cigarette packs and smokeless tobacco packs. Conclusions:The systematic review showed that PWLs on tobacco products are effective across a wide range of tobacco-related outcomes among young people. Gaps in the literature include a lack of research on tobacco initiation and cessation and a dearth of literature on non-cigarette tobacco products

Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans

Mutations in pre-synaptic voltage gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular and cellular mechanisms underlying this excitatory/inhibitory (E/I) imbalance are poorly understood. We identified a gain-of-function (gf) mutation in the Caenorhabditis elegans CaV2 channel α1 subunit, UNC-2, which leads to increased calcium currents. unc-2(zf35gf) mutants exhibit hyperactivity and seizure-like motor behaviors. Expression of the unc-2 gene with FHM1 substitutions R192Q and S218L leads to hyperactivity similar to that of unc-2(zf35gf) mutants. unc-2(zf35gf) mutants display increased cholinergic-and decreased GABAergic-transmission. Moreover, increased cholinergic transmission in unc-2(zf35gf) mutants leads to an increase of cholinergic synapses and a TAX-6/calcineurin dependent reduction of GABA synapses. Our studies reveal mechanisms through which CaV2 gain-of-function mutations disrupt excitation-inhibition balance in the nervous system.Fil: Huang, Yung Chi. University of Massachussets; Estados UnidosFil: Pirri, Jennifer K.. University of Massachussets; Estados UnidosFil: Rayes, Diego Hernán. University of Massachussets; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Gao, Shangbang. Mount Sinai Hospital; Estados UnidosFil: Mulcahy, Ben. Mount Sinai Hospital; Estados UnidosFil: Grant, Jeff. University of Massachussets; Estados UnidosFil: Saheki, Yasunori. The Rockefeller University; Estados UnidosFil: Francis, Michael M.. University of Massachussets; Estados UnidosFil: Zhen, Mei. University of Toronto; Canadá. Mount Sinai Hospital; Estados UnidosFil: Alkema, Mark J.. University of Massachussets; Estados Unido