Is there still a place for docetaxel rechallenge in prostate cancer?

Three-weekly docetaxel plus prednisone is the standard first-line cytotoxic treatment for patients with metastatic castrate-resistant prostate cancer (mCRPC). Today, several new treatment options are available for patients with tumor progression after first-line docetaxel: Abiraterone, enzalutamide, cabazitaxel, sipuleucel-T immunotherapy, and the radionuclide radium-223. However, despite the evolving scenario in CRPC treatment, the optimal sequencing of the innovative therapies remains unclear. The reintroduction of docetaxel at the occurrence of disease progression after a drug holiday (docetaxel rechallenge) was often proposed, and this chemotherapeutic agent showed to maintain antitumor activity in mCRPC patients. Docetaxel rechallenge may still constitute a valid treatment option mainly for patients with favorable response to first-line docetaxel, at least > 3 mo progression-free interval, age less than 75 years, good performance status, and acceptable docetaxel toxicity. The risk of cumulative toxicity must be evaluated, since sensory neuropathy, nail disorders and fatigue might occur on docetaxel rechallenge

Spectroscopic signature of phosphate crystallization in Erbium-doped optical fibre preforms

In rare-earth-doped silica optical fibres, the homogeneous distribution of amplifying ions and part of their spectroscopic properties are usually improved by adding selected elements, such as phosphorus or aluminum, as structural modifier. In erbium ion (Er3+) doped fibres, phosphorus preferentially coordinates to Er3+ ions to form regular cages around it. However, the crystalline structures described in literature never gave particular spectroscopic signature. In this article, we report emission and excitation spectra of Er3+ in a transparent phosphorus-doped silica fibre preform. The observed line features observed at room and low temperature are attributed to ErPO4 crystallites

Learnable Descriptors for Visual Search

This work proposes LDVS, a learnable binary local descriptor devised for matching natural images within the MPEG CDVS framework. LDVS descriptors are learned so that they can be sign-quantized and compared using the Hamming distance. The underlying convolutional architecture enjoys a moderate parameters count for operations on mobile devices. Our experiments show that LDVS descriptors perform favorably over comparable learned binary descriptors at patch matching on two different datasets. A complete pair-wise image matching pipeline is then designed around LDVS descriptors, integrating them in the reference CDVS evaluation framework. Experiments show that LDVS descriptors outperform the compressed CDVS SIFT-like descriptors at pair-wise image matching over the challenging CDVS image dataset

Method and System for Synchronizing Electronic Program Guides

A method (500) for generating a time scheduling (150) of a contents stream (140) distributed to a plurality of terminals (120) is provided. The contents stream is segmented in consecutive segments, each segment defining a corresponding program (Pi). The method includes receiving auxiliary meta data comprising a planned time scheduling of the content stream which has been set in advance and monitoring at least a portion of a segment of the contents stream to extract corresponding content features there from. The method further includes generating a corresponding fingerprint based on the extracted content features and assessing at least one among an actual start time and an actual end time of such segment based on a comparison between said fingerprint and a reference fingerprint associated with such segment. The method still further includes updating the planned time scheduling based on the assessed at least one among the actual start time and the actual end time so as to generate a time scheduling synchronized with the contents stream

VUV-Vis optical characterization of Tetraphenyl-butadiene films on glass and specular reflector substrates from room to liquid Argon temperature

The use of efficient wavelength-shifters from the vacuum-ultraviolet to the photosensor's range of sensitivity is a key feature in detectors for Dark Matter search and neutrino physics based on liquid argon scintillation detection. Thin film of Tetraphenyl-butadiene (TPB) deposited onto the surface delimiting the active volume of the detector and/or onto the photosensor optical window is the most common solution in current and planned experiments. Detector design and response can be evaluated and correctly simulated only when the properties of the optical system in use (TPB film + substrate) are fully understood. Characterization of the optical system requires specific, sometimes sophisticated optical methodologies. In this paper the main features of TPB coatings on different, commonly used substrates is reported, as a result of two independent campaigns of measurements at the specialized optical metrology labs of ENEA and University of Tor Vergata. Measured features include TPB emission spectra with lineshape and relative intensity variation recorded as a function of the film thickness and for the first time down to LAr temperature, as well as optical reflectance and transmittance spectra of the TPB coated substrates in the wavelength range of the TPB emission

Ultrasonic techniques for repair of aircraft structures with bonded composite patches

This is a paper on a research and development project to demonstrate a novel ultrasonic process for the field application of boron/epoxy (B/Ep) patches for repair of aircraft structures. The first phase of the project was on process optimization and testing to develop the most practical ultrasonic processing techniques. Accelerated testing and aging behavior of precured B/Ep patches, which were ultrasonically bonded to simulated B-52 wing panel assemblies, were performed by conducting flight-by-flight spectrum loading fatigue tests. The spectrum represented 2340 missions/flights or 30 years of service. The effects of steady-state applied temperature and prior exposure of the B/Ep composite patches were evaluated. Representative experimental results of this phase of the project are presented