Emiliano Ilardi, Annamaria Loche, Martina Marras (eds.), Utopie Mascherate. Da Rousseau a Hunger Games

Review of the book Utopie Mascherate. Da Rousseau a Hunger Games edited by Emiliano Ilardi, Annamaria Loche, Martina Marras.Recensione del libro  Utopie Mascherate. Da Rousseau a Hunger Games a cura di di Emiliano Ilardi, Annamaria Loche, Martina Marras

John Rieder, Science Fiction and the Mass Cultural Genre System

Reviwe of John Rieder's Science Fiction and the Mass Cultural Genre System.Recensione di Science Fiction and the Mass Cultural Genre System di John Rieder

Simbiosi e telepatia come basi biologiche dell'utopia in Last and First Men di Olaf Stapledon

Utopia is a privileged form of imagining the impossible and one of the central themes of Olaf Stapledon's literary and philosophical production. In Last and First Men he doesn't restrict himself to develop alternative socio-political models but he imagines a radical changing of the human nature, starting from its biological basis. The aim of the present work is to analyze the metaphorical use of biology emerging from the succession of different human species.Through the ‘close reading’ technique guided by Jameson's hermeneutic model of utopia, it will be showed how biological concepts and organic metaphors permeate crosswise the allegorical levels of body, time and collectivity. The focus will be on the theme of telepathy. As a symbolic device of maximum openness to the other, it constitutes the cornerstone of authentic community. It will be showed how this capacity is metaphorically connected to the concepts of symbiosis and symbiogenesis, explicitly represented in the text as mechanisms of speciation. The evolutionary process imagined by Stapledon, in connecting biology and ethics, appear as a critic of the first place of egoism and competition for survival, posited by social Darwinism, in favour of the communitarian ideals of solidarity and cooperation.L'utopia è una delle forme privilegiate di immaginazione dell'impossibile e uno dei temi centrali della produzione letteraria e filosofica di Olaf Stapledon. In Last and First Men egli non si limita a elaborare modelli politico-sociali alternativi ma immagina un cambiamento radicale della natura umana, a partire dalle sue basi biologiche. Lo scopo del presente lavoro è analizzare l'uso metaforico della biologia nella costruzione dell'ideale utopico della comunità autentica emergente dalla successione di diverse specie umane.Attraverso la tecnica del close reading guidata dal modello ermeneutico dell'utopia di Jameson, si mostrerà come concetti biologici e metafore organiche investano trasversalmente i livelli allegorici del corpo, del tempo e della collettività. L'attenzione sarà concentrata sul tema della telepatia. In quanto dispositivo simbolico di massima apertura all'altro, essa costituisce la pietra angolare della comunità autentica. Si mostrerà come tale facoltà si colleghi metaforicamente ai concetti di simbiosi e di simbiogenesi, esplicitamente rappresentati nel testo come meccanismi di speciazione. Il processo evolutivo immaginato da Stapledon, connettendo biologia ed etica, si configura dunque come una contestazione del primato dell'egoismo e della competizione per la sopravvivenza, postulato dal darwinismo sociale, a vantaggio degli ideali comunitari di solidarietà e cooperazione

Effetto di alcuni trattamenti preliminari sulle cinetiche di essiccamento di frutti di olivo

Olive fruits (Olea europea sativa Hoffm. and Link) of two Sardinian cultivars, after being harvested at full maturation stage, were calibrated and subjected to several preliminary treatments, in order to break the peel, before being dehydrated. Dehydration was carried out at 60°C with a constant flow rate. Fruits were placed on trays according to a completely randomised design. Dehydration kinetics were computed by taking fruits during dehydration, while changes in some chemical-physical parameters (pH, water activity and colour) were assessed by sampling at the start and at the end of the drying step. Results will be discussed. Frutti eli olivo (Olea europea sativa Hoffm. and Link) di due varietà sarde, dopo la raccolta allo stadio di completa invaiatura, sono stati calibrati e hanno subito una serie di trattamenti preliminari, atti a favorire la rottura dell'epicarpo, prima di essere sottoposti ad un processo di essiccamento. La disidratazione è stata condotta alla temperatura di 60°C ed a flusso d'aria costante, disponendo i frutti delle tesi secondo un piano completamente randomizzato. Ad intervalli prestabiliti durante l'essiccamento sono stati effettuati dei prelievi di frutti, al fine di determinare le cinetiche di essiccamento, mentre per la determinazione delle variazioni di alcuni parametri chimico-fisici (pH, attività dell'acqua e colore) è stato fatto un campionamento ad inizio ed a fine processo. Nel presente contributo saranno discussi i dati relativi alla sperimentazione

Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis

Introduction Osteoarthritis is a progressive degenerative joint disease which is high prevalent in dogs. In the late stage of the disease, it determines chronic neuropathic pain which leads to reduced quality-of-life in affected patients. To date it has not yet been identified a specific treatment, but it has been proved that nutraceutical and dietary supplements may play an important role in controlling inflammation and pain. The aim of this study was to evaluate, by the use of force plate gait analysis, the clinical efficacy of Boswellia and Curcuvet® combined with conventional nutraceutical therapy compared with conventional nutraceutical alone in dogs affected by osteoarthritis. Materials and methods Twenty client-owned dogs, over 12 months old and 20 kg of body-weight, with a confirmed diagnosis of Osteoarthritis, were included in this randomized, double-blinded study. The dogs were randomly divided into two groups: the first group (A) received a conventional nutraceutical (consisted in a preparation of glucosamine, chondroitin sulfate, fish-oil containing 80% of omega 3-fatty acid, vitamin C and E, saccharomyces Cerevisiae) with a combination of acid boswellic and Curcuvet®, while the second group (B) received a conventional nutraceutical. All the enrolled dogs underwent a washout period before starting the treatment with nutraceuticals products which were the only admitted treatment over the study period. A full orthopaedic and neurologic examination, and force plate gait analysis were performed before starting the treatment, at 45, 90, and 60 days post-treatment. Ground reaction forces were recorded and analyzed. Results Twenty dogs were enrolled in the study. In both groups there was an increasing values of ground reaction forces. These results might indicate that both nutraceutical products determined a better condition in terms of pain feeling but that effect is much more visible after 60 days from the end of the administration in treated group. Discussion In conclusion Curcuvet in combination with Boswellic acid could be considered a valid aid in a multimodal treatment for canine osteoarthritis

The Role of DNA Amplification and Cultural Growth in Complicated Acute Appendicitis

Bacterial growth of peritoneal fluid specimens obtained during surgical procedures for acute appendicitis may be useful to optimize further antibiotic therapy in complicated cases. DNA amplification represents a fast technique to detect microbial sequences. We aimed to compare the potential of DNA amplification versus traditional bacterial growth culture highlighting advantages and drawbacks in a surgical setting. Peritoneal fluid specimens were collected during surgery from 36 children who underwent appendectomy between May and December 2012. Real-time polymerase chain reaction (RT-PCR) and cultures were performed on each sample. RT-PCR showed an amplification of 16S in 18/36 samples, <em>Escherichia coli</em> (in 7 cases), <em>Pseudomonas aeruginosa</em> (3), <em>Fusobacterium necrophorum</em> (3), <em>Adenovirus</em> (2), <em>E.coli</em> (1), <em>Klebsiella pneumoniae</em> (1), <em>Serratia marcescens/Enterobacter cloacae</em> (1). Bacterial growth was instead observed only in four patients (3 <em>E.coli</em> and 1 <em>P.aeruginosa</em> and <em>Bacteroides ovatus</em>). Preoperative C-reactive protein and inflammation degree, the most reliable indicators of bacterial translocation, were elevated as expected. DNA amplification was a quick and useful method to detect pathogens and it was even more valuable in detecting aggressive pathogens such as anaerobes, difficult to preserve in biological cultures; its drawbacks were the lack of biological growths and of antibiograms. In our pilot study RT-PCR and cultures did not influence the way patients were treated

Culture and Real-time Polymerase Chain reaction sensitivity in the diagnosis of invasive meningococcal disease: Does culture miss less severe cases?

BackgroundInvasive meningococcal disease (IMD) is a highly lethal disease. Diagnosis is commonly performed by culture or Realtime-PCR (qPCR).AimsOur aim was to evaluate, retrospectively, whether culture positivity correlates with higher bacterial load and fatal outcome. Our secondary aim was to compare culture and qPCR sensitivity.MethodsThe National Register for Molecular Surveillance was used as data source. Cycle threshold (CT), known to be inversely correlated with bacterial load, was used to compare bacterial load in different samples.ResultsThree-hundred-thirteen patients were found positive for Neisseria meningitidis by qPCR, or culture, or both; 41 died (case fatality rate 13.1%); 128/143 (89.5%) blood samples and 138/144 (95.8%) CSF were positive by qPCR, 37/143 (25.9%) blood samples and 45/144 (31.2%) CSF were also positive in culture. qPCR was 3.5 times (blood) or 3.1 times (CSF) more sensitive than culture in achieving a laboratory diagnosis of IMD (OR 24.4; 95% CI 12.2-49.8; p ConclusionsIn conclusion our study demonstrated that qPCR is significantly (at least 3 times) more sensitive than culture in the laboratory confirmation of IMD. The study also demonstrated that culture negativity is not associated with lower bacterial loads and with less severe cases. On the other side, in patients with sepsis, qPCR can predict fatal outcome since higher bacterial load, evaluated by qPCR, appears strictly associated with most severe cases and fatal outcome. The study also showed that molecular techniques such as qPCR can provide a valuable addition to the proportion of diagnosed and serotyped cases of IMD

Significant impact of pneumococcal conjugate vaccination on pediatric parapneumonic effusion: Italy 2006-2018

Abstract Etiology and serotyping of parapneumonic effusion (PPE) and the impact of vaccination was evaluated over a 12-year period, before and after the PCV13 introduction (2011) for Italian children From 0 to 16 years of age. Five hundred and two children were evaluated; 226 blood and 356 pleural fluid samples were obtained and tested using Realtime-PCR and culture. In the pre-PCV13 era S. pneumoniae was the most frequent pathogen identified (64/90; 71.1%) with a large predominance of serotypes 1 (42.4%), 3 (23.7%), 7F (5.1%) and 19A (11.9%). The impact of vaccination, calculated on children 0–8 years of age, demonstrated a significant reduction of PPE: with an incidence rate of 2.82 (95%CL 2.32–3.41) in the pre-PCV13 era and an age-standardized rate (ASR) of 0.66 (95% CL 0.37–1.99) in the post-PCV13 era, p  In conclusion, our findings indicate that routine immunization with PCV13 has significantly reduced the burden of childhood PPE in vaccinated children, without increasing PPE due to other bacteria and without serotype shift. Moreover, the impact of PCV13 may be underestimated due to the increase in pneumococcal surveillance in Italy. Data has also shown that Real-time PCR is an essential tool to better define the etiology of PPE and to monitor vaccination plans. Longer studies will be necessary to evaluate the role of herd protection in PPE prevention