CFD Modelling of the Condensation Inside a Supersonic Ejector Working with R134a

Abstract The present work is about CFD modelling of condensing flow inside a supersonic ejector. The geometry used for the simulations reproduces a small-scale prototype ejector chiller built at Georgia Institute of Technology (Atlanta). The working fluid is R134a, whose expansion inside the primary nozzle and mixing chamber can lead to non-equilibrium condensation phenomena. These alter the pressure and Mach profiles along the ejector, thus generating severe thermodynamic losses. The numerical analysis of non-equilibrium condensation requires modelling of the microscopic behaviour of the fluid with a high level of fidelity. In this study, the condensation of R134a is simulated by means of two in-house developed numerical models. The first considers equilibrium conditions between the phases whereas the latter reproduces the non-equilibrium behaviour of the phase transition. Comparisons are made to understand the limitations and advantages of both approaches

CFD Modeling of the Supersonic Condensation Inside a Steam Ejector

Abstract Supersonic steam ejectors are commonly used in many applications, for example suction of non-condensable gases in steam power plants or heat-powered chillers. In the specific case of ejector chillers, CFD studies of the ejector are necessary for optimization of this device because ejector performances have a direct impact on the COP of the chiller. The complex ejector flow and the high Mach numbers make characterization of the phase change inside this component difficult. Metastability effects also have to be accounted for and some CFD commercial software provide built-in wet-steam models for this purpose. A simpler approach for numerical modeling of multiphase ejector is the Homogeneous Equilibrium Model (HEM) in which the phase change occurs in equilibrium conditions, i.e. metastability is neglected. These second kinds of models are still important tools for preliminary analysis of condensing ejectors. In the present paper a comparison between commercial software wet-steam models and an in-house developed model based on HEM is presented

Experimental and computational analysis of a R744 flashing ejector

acceptedVersio

HDAC inhibition is associated to valproic acid induction of early megakaryocytic markers

Valproic acid (VPA), a histone deacetylase inhibitor, causes differentiation in different cell lines and in a cell-specific manner; yet, its effect on megakaryocytic (MK) differentiation has not been studied. We evaluated whether VPA induces MK differentiation in a UT-7 cell line through histone acetylation in the GpIIIa gene region and activation of the ERK pathway. UT-7 cells, derived from megakaryoblastic leukemia, were treated with VPA at various concentrations, and the expression of differentiation markers as well as the gene expression profile was assessed. Flow cytometry, immunoblot analysis, and RT-PCR demonstrated that VPA induced the expression of the early MK markers GpIIIa (CD61) and GpIIb/IIIa (CD41) in a dose-dependent manner. The VPA-treated cells showed hyperacetylation of the histones H3 and H4; in particular, histone acetylation was found to have been associated with CD61 expression, in that the GpIIIa promoter showed H4 hyperacetylation, as demonstrated by the chromatin immunoprecipitation assay. Furthermore, activation of the ERK pathway was involved in VPA-mediated CD61/CD41 expression and in cell adhesion, as demonstrated by using the MEK/ERK inhibitor U0126. In conclusion, the capacity of VPA to commit UT-7 cells to MK differentiation is mediated by its inhibitory action on HDAC and the long-lived activation of ERK1/2

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population

The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investigate the role of the MEK/ERK pathway in controlling the cancer stem-like phenotype using a model of rhabdospheres derived from the embryonal rhabdomyosarcoma cell line (RD)

Volcanogenic particulates and gases from Etna volcano (Italy)

Volcanic emissions represent one of the most relevant natural sources of trace elements to the troposphere. Due to their potential toxicity they may have important environmental impacts from the local to the global scale and they can severely affect the atmospheric and terrestrial environment also at timescales ranging from a few to million years. Etna volcano is known as one of the largest global contributors of magmatic gases (CO2, SO2, and halogens) and particulate matter, including some toxic trace elements. The aim of this study was to characterize the chemical composition and the mineralogical features of the volcanogenic aerosol passively emitted from Mt. Etna. Nine samples were collected by using the filtration technique at different sites on summer 2010 and 2011. Chemical and mineralogical analyses allowed to discriminate two main constituents: the first is mainly referable to the silicate component in the volcanic plume, like lithic and juvenile fragments, crystals (e.g., plagioclases, pyroxenes, oxides) and shards of volcanic glass; the second one is linked to the soluble components like sulfosalts or halide minerals (sulfates, chlorides and fluorides). These investigations are especially important in the study area because the summit of Mt. Etna is yearly visited by nearly one hundred thousand tourists that are exposed to potentially harmful compounds

Diagnostic accuracy of sonohysterography vs hysteroscopy in benign uterine endocavitary findings

OBJECTIVE: To compare diagnostic accuracy of sonohysterography vs hysteroscopy in patients with benign uterine endocavitary findings. PATIENTS AND METHODS: This retrospective study evaluated 202 patients submitted to sonohysterography after transvaginal ultrasound examination suspicious for uterine endocavitary findings. Cytological sample was taken and analyzed from the fluid used to distend the uterine cavity. Of 202 patients enrolled for this study, 86 patients underwent gynaecological surgery, of whom 77 were treated with operative hysteroscopy and 9 with other gynaecological surgical techniques. Statistical analysis was performed to evaluate diagnostic agreement between sonohysterography vs hysteroscopy and cytology vs histology. RESULTS: Diagnostic concordance between sonohysterography and hysteroscopy was significant (k value 0.87). The correlation between cytological and histological findings had a moderate level of concordance (k value 0.49).CONCLUSIONS: Sonohysterography provides a diagnostic accuracy as well as hysteroscopy, therefore, it could be considered an alternative procedure in the diagnosis of benign uterine endocavitary findings