38 research outputs found
Brief Communication: A low-cost Arduino®-based wire extensometer for earth flow monitoring
Abstract. Continuous monitoring of earth flow displacement is essential for the understanding of the dynamic of the process, its ongoing evolution and designing mitigation measures. Despite its importance, it is not always applied due to its expense and the need for integration with additional sensors to monitor factors controlling movement. To overcome these problems, we developed and tested a low-cost Arduino-based wire-rail extensometer integrating a data logger, a power system and multiple digital and analog inputs. The system is equipped with a high-precision position transducer that in the test configuration offers a measuring range of 1023 mm and an associated accuracy of ±1 mm, and integrates an operating temperature sensor that should allow potential thermal drift that typically affects this kind of systems to be identified and corrected. A field test, conducted at the Pietrafitta earth flow where additional monitoring systems had been installed, indicates a high reliability of the measurement and a high monitoring stability without visible thermal drift
Inventory of Vietri-Maiori landslides induced by the storm of October 1954 (southern Italy)
On 25 October 1954, a storm hit the area surrounding the villages of Vietri sul Mare and Maiori of the Amalfi Coast (southern Italy) causing more than 300 deaths and severe damage to infrastructures and agriculture. This event has been among the most catastrophic historically documented in Campania Region. On this basis, and considering the lack of an existing complete characterization of the event in terms of triggered slope processes, we used multiple sets of stereoscopic aerial photos and a LiDAR-derived high-resolution topography to produce an event landslide inventory map. Our map provides an overview of the landslide distribution and extent in the area that mainly suffered the effect of the storm and is the basis for a morphometric characterization of landslide source areas that we present in this paper as simplified statistical analysis. In addition, we compared the rainfall distribution with the spatial density of source areas
Flood hazard of major river segments, Benevento Province, Southern Italy
On 15 October 2015, a storm-induced flood hit the central sector of Benevento Province (southern Italy) causing two deaths and severe damage to infrastructure, buildings and local agriculture. This area has a long history of similar events and since 1924 its major river segments have been monitored with several hydrometric stations. We used data from two of these stations and a LiDAR derived high-resolution topography to develop a flood hazard map. For map computation, we first derived a flood inundation map from topography. Subsequently we estimated the probability of exceedance of each specific fluvial stage from the combination of a Generalized Extreme Value and a Gamma fits of available hydrometric data. As boundary condition, we considered a reference scenario corresponding to an estimated 500 year flood. The hazard maps provide an overview of the flood hazard in the central sector of Benevento Province and floodplains zonation in flood perspective
PS-driven inventory of town-damaging landslides in the Benevento, Avellino and Salerno Provinces, southern Italy
The Apennine provinces of Campania Region (southern Italy), Benevento, Avellino and Salerno, are known for their 'unstable towns' suffering periodic damage from landslides. Their identification and mapping are very challenging tasks, since boundary mapping under urban settlements is not always possible without time-consuming field analysis of building damage and/or expensive mid-term diffuse ground-surface deformation monitoring. To overcome this problem, an inventory of town-damaging landslides, guided by available Permanent Scatterers (PS) ground-deformation data, was prepared. It provides an updated tool suitable to guide future land planning and historical site restoration in the Apennine provinces of Campania Region. Our fourteen Map Sheets show active and local reactivation of suspended/dormant landslides. Overall, 356 landslides were identified, amongst which 162 were identified as flows, 101 as slides, 1 as a spreads and 92 as complex landslides. To supplement our maps, a simplified distribution analysis based on major landslide morphometric characteristics was completed
Pathology reporting in neuroendocrine neoplasms of the digestive system: everything you always wanted to know but were too afraid to ask
During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals
Commentary: Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management
In the issue of March 2021, Lenschow et al. reported the case of a 46-year-old woman with recurrent, programmed death-ligand-1 (PD-L1) negative, tumor mutational burden (TMB)-high parathyroid carcinoma (PC), who showed stable disease as her best response on imaging, and a three-fold drop in PTH after treatment with intravenous pembrolizumab. Given the remarkable results obtained by Lenschow et al. with the anti-PD-1 agent pembrolizumab in the above-mentioned case, we performed an extensive search for possible further relevant data sources, including a) full published articles in international online databases (PubMed, Web of Science, Scopus, and Embase); b) preliminary reports in selected international meeting abstract repositories (American Society of Clinical Oncology, ASCO; European Neuroendocrine Tumor Society, ENET; European Society for Medical Oncology, ESMO); c) registered clinical trials in the U.S. National Institutes of Health registry of clinical trials (http://clinicaltrials.gov) and in any primary register of the WHO International Clinical Trials Registry Platform (ICTRP)
Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription
Femicide and murdered women’s children: which future for these children orphans of a living parent?
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Further hydrological analyses on landslide initiation in the sarno area (Italy)
In a wide area of Campania, characterised by mountain ridges covered by pyroclastic deposits, landslides occur after intense rainstorms that follow an accumulation of a certain amount of prestorm seasonal rainfall. Instabilities begin as soil slides, and evolve to debris avalanche-flow along steep slopes. This study extends the hydrological analyses carried out by FIORILLO & WILSON (2004) on these landslides. Further 10-years of rainfall records allow to verify a previous hypothesis on the soil moisture accumulation into the soil. Analyses have been focused in the Sarno area (P.zzo d'Alvano), where a high-elevation rain-gauge is available since 1998, which allows also to compare data with lowelevation rain gauges. Analyses show that numerous large-scale debris flows induced by the May 1998 storm depend heavily on the antecedent rainfall distribution and on the soil moisture storage characteristics. © Società Geologica Italiana, Roma 2013