A Scholar in Action in Interwar America. John H. Williams’ contributions to trade theory and international monetary reform

In this paper we analyse the scientific contributions of Harvard economist John H. Williams as international trade theorist and monetary reformer, together with his activities as a Vice President of the Federal Reserve Bank of New York. In the first two Sections we present a succinct overview of Williams’ main contributions to international trade theory and to the interwar debate on the reform of the international monetary system. Particular attention will be devoted to his early academic writings which contained different critical arguments against the two main tenets of classical international economics: the Ricardian theory of comparative advantages and the gold standard. These criticisms formed the theoretical rationale and the analytical background of Williams’ key currency approach to the reform of the international monetary system. The key currency plan was first formulated when Williams advised Roosevelt and Morghenthau to sign a Tripartite agreement with Britain and France, and was later refined during the negotiations which concluded with the approval of the Bretton Woods agreements. In this respect, Section 4 is devoted to the analysis of the contents of Williams’ proposal and to the reconstruction of his main criticisms of the two official plans presented by John Maynard Keynes and Harry Dexter White. Section 5 is devoted to examining Keynes’ and White’s reactions and to elucidating what aspects of Williams’ ideas managed to influence the shaping of the Bretton Woods Agreements. Finally, Section 6 presents some general conclusions. Sections 4 and 5 have greatly benefited from the use of archival sources which have been quoted at length, mostly in the footnotesJohn H. Williams; John Maynard Keynes; Harry D. White; Bretton Woods Agreements; Key currency; gold standard; economists in Government

Exploration of Adaptive Origami Shading Concepts through Integrated Dynamic Simulations

This paper presents integrated energy and lighting simulations as a part of wider research focused on the form-finding process of adaptive shading concepts and on the actuation of shading movement using shape memory alloys (SMAs). The use of this new type of microactuator in responsive architectural components presents a challenge because of the limited contraction state of the SMAs. Hence, origami shapes were considered to amplify shading movements thanks to their geometric properties. This study exploited the visual and thermal comfort of a south-oriented office located in Milan, Italy, that was equipped with adaptive origami shading. Two-hundred and ten shapes were considered and the geometry, contraction states, and surface materials were considered as variable properties. The final aim was to explore the potential of adaptive origami shadings in controlling visual and thermal comfort. Daylight illuminance (UDI), daylight glare probability (DGP), and total energy (TE) demand (for cooling, heating, and lighting per year) were used as main metrics for understanding the environmental benefits of the proposed shading devices

shaping an origami shading device through visual and thermal simulations

Abstract This paper presents the first results of a research work aimed at the optimisation of a shading system through parameters of visual comfort – Useful Daylight Illuminance (UDI), Daylight autonomy (DA) and Daylight Glare Probability (DGP) – and Total Energy (TE) consumption (cooling, heating and lighting per year). The goal is to define a shading system for office buildings that delivers visual comfort for users whilst reducing energy consumption for indoor climate control and artificial lighting. As the design of the shading system considers the use of shape memory alloys (SMA) as micro-actuators to accomplish solar adaptation, Origami pattern has been adopted to guarantee a relatively large displacement of the shading system with a small deformation of the SMA wires actuators. Thanks to this shape change, generating overlapped pleats and angle variation and using different materials, it has been possible to provide alterations of the direct light transmission inside the building while maintaining a certain degree of diffuse light component

District Geometry Simulation: A Study for the Optimization of Solar Façades in Urban Canopy Layers

open4This paper shows the results of a research aimed at assessing the amount of energy that can be produced by solar envelopes (facades and roofs) in urban contexts.A preliminary set of simulations was carried out, through dynamic yearly analyses on a sample building, to identify the main parameters influencing the availability of solar radiation and to optimize the building's shape. The general target is to maximise solar radiation available on the external building envelope, in order to exploit it through building integrated solar systems.Furthermore, the effect of reflected solar radiation has been analysed by simulating different finishing materials (green façades, glazed façades, concrete façades and aluminium façades) on the neighbouring buildings.G. Lobaccaro; F. Fiorito; G. Masera; T. PoliLobaccaro, Gabriele; F., Fiorito; Masera, Gabriele; Poli, Tizian

Automated Resonance Assignment of Proteins: 6 DAPSY-NMR

The 6-dimensional(6D) APSY-seq-HNCOCANH NMR experiment correlates two sequentially neighbor in gamidemoieties in proteins via the C′ and Cα nuclei, with efficient suppression of the back transfer from Cα to the originating amidemoiety. The automatic analysis of two-dimensional(2D) projections of this 6D experiment with the use of GAPRO (Hilleretal., 2005) provides a high-precision 6D peak list, which permits automated sequential assignments of proteins with the assignment software GARANT (Bartels et al., 1997). The procedure was applied to two proteins, the 63-residue 434-repressor(1-3) and the 115-residue TM1290. For both proteins, complete sequential assignments for all NMR-observable backbone resonances were obtained, and the polypeptide segments thus identified could be unambiguously located in the amino acid sequence. These results demonstrate that APSY-NMR spectroscopy in combination with a suitable assignment algorithm can provide fully automated sequence-specific backbone assignments of small protein

Kinetic Solar Skin: A Responsive Folding Technique

The paper focuses on optimized movements analysed by means of Origami, the Japanese traditional art of paper folding. The study is a way to achieve different deployable shading systems categorized by a series of parameters that describe the strengths and weaknesses of each tessellation. Through the kinetic behaviour of Origami geometries the research compares simple folding diagrams with the purpose to understand the deployment at global scale and thus the potential of kinetic patterns’ morphology for application in adaptive facades. The possibilities of using a responsive folding technique to develop a kinetic surface that can change its configuration are here examined through the variation of parameters that influence kinematics’ form. Moreover, in order to perform the shape change without any external mechanical devices, the use of Shape Memory Alloy (SMA) actuators has been tested

Automated Resonance Assignment of Proteins: 6 DAPSY-NMR

The 6-dimensional(6D) APSY-seq-HNCOCANH NMR experiment correlates two sequentially neighbor in gamidemoieties in proteins via the C′ and Cα nuclei, with efficient suppression of the back transfer from Cα to the originating amidemoiety. The automatic analysis of two-dimensional(2D) projections of this 6D experiment with the use of GAPRO (Hilleretal., 2005) provides a high-precision 6D peak list, which permits automated sequential assignments of proteins with the assignment software GARANT (Bartels et al., 1997). The procedure was applied to two proteins, the 63-residue 434-repressor(1-3) and the 115-residue TM1290. For both proteins, complete sequential assignments for all NMR-observable backbone resonances were obtained, and the polypeptide segments thus identified could be unambiguously located in the amino acid sequence. These results demonstrate that APSY-NMR spectroscopy in combination with a suitable assignment algorithm can provide fully automated sequence-specific backbone assignments of small proteins

Automated amino acid side-chain NMR assignment of proteins using 13C- and 15N-resolved 3D [1H,1H]-NOESY

ASCAN is a new algorithm for automatic sequence-specific NMR assignment of amino acid side-chains in proteins, which uses as input the primary structure of the protein, chemical shift lists of 1HN, 15N, 13Cα, 13Cβ and possibly 1Hα from the previous polypeptide backbone assignment, and one or several 3D 13C- or 15N-resolved [1H,1H]-NOESY spectra. ASCAN has also been laid out for the use of TOCSY-type data sets as supplementary input. The program assigns new resonances based on comparison of the NMR signals expected from the chemical structure with the experimentally observed NOESY peak patterns. The core parts of the algorithm are a procedure for generating expected peak positions, which is based on variable combinations of assigned and unassigned resonances that arise for the different amino acid types during the assignment procedure, and a corresponding set of acceptance criteria for assignments based on the NMR experiments used. Expected patterns of NOESY cross peaks involving unassigned resonances are generated using the list of previously assigned resonances, and tentative chemical shift values for the unassigned signals taken from the BMRB statistics for globular proteins. Use of this approach with the 101-amino acid residue protein FimD(25-125) resulted in 84% of the hydrogen atoms and their covalently bound heavy atoms being assigned with a correctness rate of 90%. Use of these side-chain assignments as input for automated NOE assignment and structure calculation with the ATNOS/CANDID/DYANA program suite yielded structure bundles of comparable quality, in terms of precision and accuracy of the atomic coordinates, as those of a reference structure determined with interactive assignment procedures. A rationale for the high quality of the ASCAN-based structure determination results from an analysis of the distribution of the assigned side chains, which revealed near-complete assignments in the core of the protein, with most of the incompletely assigned residues located at or near the protein surfac

Canine Coronavirus Activates Aryl Hydrocarbon Receptor during In Vitro Infection

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with substrates, including microbial metabolites. Recent advances reveal that AhR is involved in the host response to coronaviruses (CoVs) infection. Particularly, AhR antagonists decrease the expression of angiotensin-converting enzyme 2 (ACE2) via AhR up-regulation, resulting in suppression of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in mammalian cells. Herein, we report that AhR is expressed in canine fibrosarcoma (A72) cells, where it is considerably activated by infection with genotype II of canine coronavirus (CCoV-II). The pharmacological inhibition of AhR, by CH223191, suppressed cell death signs and increased cell viability. Furthermore, the AhR antagonist induced a meaningful decline in virus yield, accompanied by the inhibition of the expression of viral nuclear protein (NP). Fascinatingly, during CCoV infection, a novel co-expression of NP and AhR expression was found. Taken together, our preliminary findings show that infection with CCoV activates AhR, and pharmacologic AhR inhibition reduces CCoV replication, identifying AhR as a possible candidate target for CCoV antiviral therapy