Quantum theory of fluctuations in a cold damped accelerometer

We present a quantum network approach to real high sensitivity measurements. Thermal and quantum fluctuations due to active as well as passive elements are taken into account. The method is applied to the analysis of the capacitive accelerometer using the cold damping technique, developed for fundamental physics in space by ONERA and the ultimate limits of this instrument are discussed. It is confirmed in this quantum analysis that the cold damping technique allows one to control efficiently the test mass motion without degrading the noise level.Comment: 10 pages, 6 figures, RevTeX; Minor change

A genome search for primary vesicoureteral reflux shows further evidence for genetic heterogeneity

Vesicoureteral reflux (VUR) is the most common disease of the urinary tract in children. In order to identify gene(s) involved in this complex disorder, we performed a genome-wide search in a selected sample of 31 patients with primary VUR from eight families originating from southern Italy. Sixteen additional families with 41 patients were included in a second stage. Nonparametric, affected-only linkage analysis identified four genomic areas on chromosomes 1, 3, and 4 (p < 0.05); the best result corresponded to the D3S3681-D3S1569 interval on chromosome 3 (nonparametric linkage score, NPL = 2.75, p = 0.008). This region was then saturated with 26 additional markers, tested in the complete group of 72 patients from 24 families (NPL = 2.01, p = 0.01). We identified a genomic area on 3q22.2-23, where 26 patients from six multiplex families shared overlapping haplotypes. However, we did not find evidence for a common ancestral haplotype. The region on chromosome 1 was delimited to 1p36.2-34.3 (D1S228-D1S255, max. NPL = 1.70, p = 0.03), after additional fine typing. Furthermore, on chromosome 22q11.22-12.3, patients from a single family showed excess allele sharing (NPL = 3.35, p = 0.015). Only the chromosome 3q region has been previously reported in the single genome-wide screening available for primary VUR. Our results suggest the presence of several novel loci for primary VUR, giving further evidence for the genetic heterogeneity of this disorder

Efficacy of a new technique - INtubate-RECruit-SURfactant-Extubate - "IN-REC-SUR-E" - in preterm neonates with respiratory distress syndrome: Study protocol for a randomized controlled trial

Background: Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful in all preterm neonates with respiratory distress syndrome, with a reported failure rate ranging from 19 to 69&nbsp;%. One of the possible mechanisms responsible for the unsuccessful IN-SUR-E method, requiring subsequent re-intubation and mechanical ventilation, is the inability of the preterm lung to achieve and maintain an "optimal" functional residual capacity. The importance of lung recruitment before surfactant administration has been demonstrated in animal studies showing that recruitment leads to a more homogeneous surfactant distribution within the lungs. Therefore, the aim of this study is to compare the application of a recruitment maneuver using the high-frequency oscillatory ventilation (HFOV) modality just before the surfactant administration followed by rapid extubation (INtubate-RECruit-SURfactant-Extubate: IN-REC-SUR-E) with IN-SUR-E alone in spontaneously breathing preterm infants requiring nasal continuous positive airway pressure (nCPAP) as initial respiratory support and reaching pre-defined CPAP failure criteria. Methods/design: In this study, 206 spontaneously breathing infants born at 24+0-27+6 weeks' gestation and failing nCPAP during the first 24&nbsp;h of life, will be randomized to receive an HFOV recruitment maneuver (IN-REC-SUR-E) or no recruitment maneuver (IN-SUR-E) just prior to surfactant administration followed by prompt extubation. The primary outcome is the need for mechanical ventilation within the first 3&nbsp;days of life. Infants in both groups will be considered to have reached the primary outcome when they are not extubated within 30&nbsp;min after surfactant administration or when they meet the nCPAP failure criteria after extubation. Discussion: From all available data no definitive evidence exists about a positive effect of recruitment before surfactant instillation, but a rationale exists for testing the following hypothesis: a lung recruitment maneuver performed with a step-by-step Continuous Distending Pressure increase during High-Frequency Oscillatory Ventilation (and not with a sustained inflation) could have a positive effects in terms of improved surfactant distribution and consequent its major efficacy in preterm newborns with respiratory distress syndrome. This represents our challenge. Trial registration: ClinicalTrials.gov identifier: NCT02482766. Registered on 1 June 2015

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Fluctuations quantiques et thermiques dans les transducteurs électromécaniques

Fluctuations are present in any measurement and determine the ultimate sensitivity. This is particularly true for the fundamental fluctuations, namely thermal and quantum noise. The first objective of this thesis has been to develop a general method allowing us to treat measurement systems consisting of passive elements and active ones, the latter being used for amplification and feedback. This method, based on network theory and on the quantum scattering matrix formalism, is applicable to linear systems and, in a more general case, to systems linearisable around the working point. It can take into account all noise sources and can, therefore, describe accurately a non ideal, real, measurement. Its modular character is well-adapted for the treatment of complex systems. The second objective has been to study the influence of quantum and thermal fluctuations on electromecanical measurements. The noise in such systems is usually dominated by thermal fluctuations, but has been pushed towards the quantum limits by ambitious experimental studies requiring very high sensitivity (detection of gravitational waves, test of the equivalence principle in outer space) and due to the technological development in the field of cryogenics. The method developed in this thesis provides a consistent theoretical framework for the treatment of quantum and thermal fluctuations in these systems. In particular, results have been obtained for an accelerometer developed at ONERA for fundamental physical experiments in space, which has the specific feature of employing the mechanism of cold damping. The results allow for an estimate of the ultimate sensitivity limits of such an instrument.Les fluctuations sont présentes dans toute mesure et elles en limitent la sensibilité ultime. Ceci est vrai en particulier pour les fluctuations de nature fondamentale qui correspondent au bruit thermique et au bruit quantique. Un premier objectif de cette thèse a été le développement d'une méthode générale qui permette le traitement de ces fluctuations dans des systèmes de mesure comportant des éléments passifs et des éléments actifs remplissant des fonctions d'amplification ou de contre-réaction. Cette méthode, basée d'une part sur la théorie des réseaux, d'autre part sur le formalisme quantique de la matrice S, s'applique aux systèmes linéaires et, plus généralement, aux systèmes linéarisables autour du point de fonctionnement. Elle peut prendre en compte toutes les sources de bruit et décrit donc la non-idéalité de la mesure. Son caractère modulaire se prête bien au traitement des systèmes complexes. Un deuxième objectif a été l'étude des effets des fluctuations quantiques et thermiques sur la sensibilité des mesures électromécaniques. Le bruit dans ces systèmes, habituellement dominé par les fluctuations thermiques, s'est rapproché du niveau quantique, sous la pression des expériences nécessitant de très hautes sensibilités (détection des ondes gravitationnelles, test du principe d'équivalence dans l'espace) et grâce aux développements technologiques dans le domaine cryogénique. La méthode développée dans cette thèse fournit un cadre théorique consistent pour traiter fluctuations quantiques et thermiques dans ces systèmes. Des résultats précis ont été obtenus pour un accéléromètre conçu par l'ONERA pour des expériences de physique fondamentale dans l'espace et qui présente la particularité d'utiliser un mécanisme de friction froide. Ces résultats permettent d'estimer les limites ultimes de sensibilité d'un tel instrument