Accurate Characterization by Dielectric Spectroscopy up to 25 GHz of Nano-liter Range Liquid Volume within a Microfluidic Channel

International audienceThis paper reports the design, simulation and experimental validation of an accurate liquid sensing technique in the nano-liter range. It is suitable for the detection and quantification of very small contents of liquid samples containing biological cells. The biosensor is based on an open-ended interdigitated capacitor (IDC) within a microfluidic channel. The microwave structure including the IDC is patterned in coplanar waveguide technology. The microfluidic channel is 100μm thick and the IDC covers an area of 150μm width and 90μm length. This leads to a volume under analysis much lower than a nano-liter which allows the noninvasive and contactless microwave investigation of biological cells in their culture medium. This micro-device is used to extract the complex permittivity of liquid media from the measured scattering parameters within the frequency band ranging from 0.2 to 25 GHz. For ease of use, a SMA-connectorized version of the device with spring contacts probes to the biosensor is also proposed. Results concerning microparticle detection within the media are also presented, extending the use of the sensors to cellular environments

Le cadmium en milieu marin : biogeochimie et ecotoxicologie

Programme IFREMER : Etudes en soutien a la definition des normesAvailable at INIST (FR), Document Supply Service, under shelf-number : 14435 C, issue : a.1989 n.16 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Decontamination experimentale de bivalves toxiques : application aux phycotoxines paralysantes

Available from INIST (FR), Document Supply Service, under shelf-number : RP 185 (4018) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEMinistere de l'Environnement, 75 - Paris (France). Service de la Recherche et des Affaires Economiques (SRAE)FRFranc

Changement climatique et population

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : RP 185 (3930) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Gyrodinium cf. aureolum Recherche de facteurs toxinogenes, role des ectocrines et conditions de production

Available at INIST (FR), Document Supply Service, under shelf-number : RP 185 (2799) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Dynamiques spatiales et temporelles de la reconstitution des peuplements de vers de terre dans des milieux en voie de regeneration

Comite Ecologie et Gestion du Patrimoine Naturel (EGPN), programme 'Dynamique de la biodiversite et gestion de l'espace'Available from INIST (FR), Document Supply Service, under shelf-number : RP 185 (4231) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEMinistere de l'Environnement, 75 - Paris (France). Service de la Recherche et des Affaires Economiques (SRAE)FRFranc

Conservation de la fertilite des sols tropicaux humides par l'introduction de vers de terre selectionnes - mise en place d'experiences a grande echelle

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : RP 185 (3199) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

International audienceThe aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed