Patient-reported outcomes in clinical trials of inhaled asthma medications: systematic review and research needs

Numerous validated PRO instruments are available but it is unclear why few are used in asthma clinical trials. Problems include poor reporting, and uncritical analysis and interpretation of PRO scores. Research needs include identifying and recommending a set of PROs for use in asthma clinical research and providing guidance for researchers on the application, analysis and interpretation of PRO measures in clinical trials

Production of doubly charged vector bilepton pairs at γγ\gamma \gamma colliders

The production of pairs of doubly charged vector bileptons is studied at future $\gamma \gamma$ colliders. The unpolarized cross--section for the $\gamma \gamma \to Y^{--}Y^{++}$ subprocess is analytically calculated and convoluted to predict the number of events in the complete $e^+e^-\to \gamma \gamma \to Y^{--}Y^{++}$ process. The gauge or non--gauge character of the vector bilepton $Y^{\pm \pm}$ is discussed. It is found that as a consequence of its spectacular signature, as it decays dominantly into two identical charged leptons, and also due to its charge contents, which significantly enhance the cross--section, the detection of this class of particles with mass in the sub--TeV region can be at the reach of these colliders. The model--independent nature of our results is stressed.Comment: 9 pages, 7 figures, submitted to physical review

By Dint of History: Ways in which social work is r(re) defined by historical and social events

This paper examines aspects of the historico-political development of social work in the UK and Germany, acknowledging some of the contested aspects of historical analysis. The article examines four core areas in which social work has adapted to the influence of historical events – the English Poor Laws, political turmoil and the rise of National Socialism in Germany, the turn towards indigeneity in contemporary practice, and the increasing populism and politicisation in care across both countries. These are understood in terms of power and the discourses created through social, political and historical change

CP Violation and F-theory GUTs

Recent work on F-theory GUTs has shown that the predicted masses, and magnitudes of the mixing matrix elements in the quark and lepton sectors are in close accord with experiment. In this note we estimate the CP violating phase of the mixing matrices by considering the Jarlskog invariant. We find by carefully treating certain cancellations in the computation of the Jarlskog invariant that |J_quark| ~ alpha_GUT^(3) ~ 6*10^(-5), and that the CP violating phase of the quark sector is large, in accord with experiment. Moreover, we predict (up to order one factors) that |J_lepton| ~ alpha_GUT ~ 4*10^(-2) and that the CP violating phase of the lepton sector is also large.Comment: v2: 3 pages, Improved estimate of the Jarlskog invariant involving subtle cancellations, leading to a different conclusion for the CP violating phas

An association between lifespan and variation in insulin-like growth factor I receptor in sheep

Longevity in livestock is a valuable trait. When productive animals live longer, fewer replacement animals need to be raised. However, selection for longevity is not commonly the focus of breeding programs as direct selection for long-lived breeding stock is virtually impossible until late in the reproductive life of the animal. Additionally the underlying genetic factors or genes associated with longevity are either not known, or not well understood. In humans, there is evidence that IGF 1 receptor (IGF1R) is involved in longevity. Polymorphism in the IGF1R gene has been associated with longevity in a number of species. Recently, 3 alleles of ovine IGF1R were identified, but no analysis of the effect of IGF1R variation on sheep longevity has been reported. In this study, associations between ovine IGF1R variation, longevity and fertility were investigated. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) was used to type IGF1R variation in 1,716 New Zealand sheep belonging to 6 breeds and 36 flocks. Ovine IGF1R C was associated with age when adjusting for flock (present 5.5 ± 0.2 yr, absent 5.0 ± 0.1 yr, P = 0.02). A general linear mixed effects model suggested an association (P = 0.06) between age and genotype, when correcting for flock. Pairwise comparison (least significant difference) of specific genotypes revealed the difference to be between AA (5.0± 0.1 yr) and AC (5.6 ± 0.2 yr, P = 0.02). A weak negative Pearson correlation between fertility and longevity traits was observed (r = -0.25, P < 0.01). The finding of an association between variation in IGF1R and lifespan in sheep may be useful in prolonging the lifespan of sheep

SOSA MORALES, MANUEL Y NOVIA [Material gráfico]

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Application of Systematic Review Methodology to Food and Feed Safety Assessments to Support Decision Making

Systematic reviews are commonly used in human health research to provide overviews of existing evidence pertinent to clearly formulated specific questions, using pre-specified and standardised methods to identify and critically appraise relevant research, and to collect, report and analyse data from the studies that are included in the reviews. Formal systematic reviews have rarely been used in food and feed safety risk assessments and the existing systematic review methods in other disciplines may not be directly applicable in this field. This Guidance aims to assist the application of systematic reviews to food and feed safety risk assessments in support of decision making, by describing a framework for identifying the different types of question suitable for systematic review generated by the risk assessment process and for determining the need for systematic reviews when dealing with broad food and feed safety policy problems. The Guidance provides suggestions and examples for the conduct of eight key steps in the systematic review process (preparing a review, searching for studies, selecting studies for inclusion, collecting data from included studies, assessing the methodological quality of included studies, synthesising data from the studies, presenting data and results, and interpreting the results and drawing conclusions) for questions suitable for systematic reviews, taking into account issues that may be unique to food and feed safety. Due to its methodological rigor and its objective and transparent nature, systematic review methodology and its principles could provide additional value for answering well-formulated specific questions generated by the risk assessment process or other analytical frameworks in food and feed safety. Regular updates of this Guidance are foreseen in light of experience and new evidence both in food and feed safety and systematic review methodology

The Digital Underworld: Combating Crime on the Dark Web in the Modern Era

The Digital Underworld: Combating Crime on the Dark Web in the Modern Er