Cazier, Jean-Baptiste

Frampton, Jonathan

Sundar, Sudha

English

Cumulatively, breast, cervical, ovarian, and uterine cancer account for more than 70% of cancers in women in India. Distinct differences in the clinical presentation of women with cancer suggest underlying differences in cancer biology and genetics. The peak age of onset of breast and ovarian cancer appears to be a decade earlier in India (age 45–50 years) than in high-income countries (age &gt;60 years). Understanding these differences through research to develop diagnosis, screening, prevention, and treatment frameworks that ar e specific to the Indian population are critical and essential to improving women's health in India. Since the sequencing of the human genome in 2001, applications of advanced technologies, such as massively parallel sequencing, have transformed the understanding of the genetic and environmental drivers of cancer. How can advanced technologies be harnessed to provide health-care solutions at a scale and to a budget suitable for a country of 1·2 billion people? What research programmes are necessary to answer questions specific to India, and to build capacity for innovative solutions using these technologies? In order to answer these questions, we convened a workshop with key stakeholders to address these issues. In this Series paper, we highlight challenges in tackling the growing cancer burden in India, discuss ongoing genomics research and developments in infrastructure, and suggest key priorities for future research in cancer in India

Sundar, S

Khetrapal-Singh, P

Frampton, J

Trimble, E

Rajaraman, P

Mehrotra, R

Hariprasad, R

Maitra, A

Gill, P

Suri, V

Srinivasan, R

Singh, G

Cazier, JB

University of Birmingham Research Portal

  Harnessing genomics to improve outcomes forwomen with cancer in India: key priorities forresearchSundar, Sudha; Cazier, Jean-Baptiste; Frampton, JonathanDOI:10.1016/S1470-2045(17)30726-XLicense:Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)Document VersionPeer reviewed versionCitation for published version (Harvard):Sundar, S, Cazier, J-B & Frampton, J 2018, 'Harnessing genomics to improve outcomes for women with cancerin India: key priorities for research', The Lancet Oncology, vol. 19, no. 2, pp. e102–e112.https://doi.org/10.1016/S1470-2045(17)30726-XLink to publication on Research at Birmingham portalPublisher Rights Statement:Checked for eligibility: 12/10/2017General rightsUnless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or thecopyright holders. The express permission of the copyright holder must be obtained for any use of this material other than for purposespermitted by law.•	Users may freely distribute the URL that is used to identify this publication.•	Users may download and/or print one copy of the publication from the University of Birmingham research portal for the purpose of privatestudy or non-commercial research.•	User may use extracts from the document in line with the concept of ‘fair dealing’ under the Copyright, Designs and Patents Act 1988 (?)•	Users may not further distribute the material nor use it for the purposes of commercial gain.Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document.When citing, please reference the published version.Take down policyWhile the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has beenuploaded in error or has been deemed to be commercially or otherwise sensitive.If you believe that this is the case for this document, please contact UBIRA@lists.bham.ac.uk providing details and we will remove access tothe work immediately and investigate.Download date: 01. Feb. 2019Box -1 Key priorities for research in women’s cancer genomics research in India   1. Multicentre large scale studies to investigate the clinico-pathological phenotype using standardised datasets and definitions to establish the phenotype, distribution and outcomes from women’s cancer in urban and rural areas. 2. Investigating differences in prevalence of cancer, environmental risk factors,  HPV type distribution and genome variants across different regions of India  3. Establishing a pan Indian genomic variant data resource across diverse ethnic groups 4. Adequately powered Genome wide association studies with careful phenotypic data to establish risk associations and novel discovery 5. Investigating Genotype-phenotype interactions through matched studies amongst Indian diaspora living abroad and Indian populations with women’s cancer 6. Investigating prevalence and spectrum of inherited Breast, ovarian and uterine cancer susceptibility genes in unselected women with these cancers to identify ‘at risk’families, to establish acceptability of  cascade testing of family members to identify women ‘at risk’ of development of cancer and to identify the effectiveness of targeted screening and prevention efforts in women ‘at risk’ of development of cancer.   7. Investigating cultural attitudes towards genetic testing amongst patients, affected families and care givers.  8. Differences between screen detected cancers and clinically detected cancers in the Indian population and in Indian diaspora who have migrated to high income countries  

Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research

http://pure-oai.bham.ac.uk/ws/files/43382482/Sundar_et_al_harnessing_genomics_The_Lancet_Oncology_2017.pdf

Harnessing genomics to improve outcomes for women with cancer in India: key priorities for research

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