14 research outputs found
PAR12: PROSPECTIVE USE OF WEB BASED TECHNOLOGY TO EVALUATE HEALTH OUTCOMES IN A LARGE COHORT OF SEVERE OR DIFFICULT TO TREAT ASTHMATICS
MetaPro-IQ: a universal metaproteomic approach to studying human and mouse gut microbiota
PAR12: PROSPECTIVE USE OF WEB BASED TECHNOLOGY TO EVALUATE HEALTH OUTCOMES IN A LARGE COHORT OF SEVERE OR DIFFICULT TO TREAT ASTHMATICS
Full length parathyroid hormone, PTH(1-84), for the treatment of severe osteoporosis in postmenopausal women
Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration
0# Diesel water-accommodated fraction induced lipid homeostasis alteration in zebrafish embryos
Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
The effect of vestibular nerve section on the expression of the hyaluronan in the frog, Rana esculenta
Decoding the microstructural correlate of diffusion MRI
Diffusion imaging has evolved considerably over the past decade. While it provides valuable information about the structural connectivity at the macroâ and mesoscopic scale, bridging the gap to the microstructure at the level of single nerve fibers poses an enormous challenge. This is particularly true for the human brain with its large size, its large whiteâmatter volume and availability of histological techniques for studying human wholeâbrain sections and subsequent 3D reconstruction. Classic postâmortem techniques for studying the fiber architecture of the brain, such as myeloarchitectonic staining or dye tracing, are complemented by novel histological approaches, such as 3D polarized light imaging or optical coherence tomography, enabling unique insight into the fiber architecture from large fiber bundles within deep white matter to single nerve fibers in the cortex. The present review discusses the benefits and challenges of these latest developments in comparison with the classic techniques, with particular focus on the mutual exchange between in vivo and postâmortem diffusion imaging and postâmortem microstructural approaches for understanding the wiring of the brain across different scales