19 research outputs found
Enfermedad de hansen (lepra): Eritema nodoso leproso presentación de caso
Hansen's disease or leprosy is a chronic course infectious disease as old as humanity itself, which throughout history has led to the isolation and alienation of anyone who has it. Nowadays due to pathogenesis knowledge and therapeutics advance we can have a different point of view about it. In the following sections we will perform an updated revision of this disease and check a 44 year-old patient case, who was diagnosed with lepromatous leprosy developing a nodosum leprosum erythema and who has also received the appropriate multidrug treatment with appropriate clinical response.La enfermedad de Hansen o lepra es una enfermedad infectocontagiosa de curso crónico tan antigua como la humanidad misma, que a lo largo de la historia ha marginado a todo aquel que la padece. En la actualidad con el conocimiento de su patogenia y avances en la terapéutica se tiene una visión diferente de la misma. En los siguientes párrafos se realiza una revisión bibliográfica actualizada y la presentación del caso clínico de un paciente de 44 años de edad, al cual se le diagnostico lepra lepromatosa con desarrollo de eritema nodoso leproso quien recibió manejo poliquimioterapéutico con adecuada evolución
Chapitre 14: Phytopathogènes et stratégies de contrôle en aquaponie
peer reviewedAmong the diversity of plant diseases occurring in aquaponics, soil-borne
pathogens, such as Fusarium spp., Phytophthora spp. and Pythium spp., are the most
problematic due to their preference for humid/aquatic environment conditions.
Phytophthora spp. and Pythium spp. which belong to the Oomycetes pseudo-fungi
require special attention because of their mobile form of dispersion, the so-called
zoospores that can move freely and actively in liquid water. In coupled aquaponics,
curative methods are still limited because of the possible toxicity of pesticides and
chemical agents for fish and beneficial bacteria (e.g. nitrifying bacteria of the
biofilter). Furthermore, the development of biocontrol agents for aquaponic use is
still at its beginning. Consequently, ways to control the initial infection and the
progression of a disease are mainly based on preventive actions and water physical
treatments. However, suppressive action (suppression) could happen in aquaponic
environment considering recent papers and the suppressive activity already
highlighted in hydroponics. In addition, aquaponic water contains organic matter
that could promote establishment and growth of heterotrophic bacteria in the system
or even improve plant growth and viability directly. With regards to organic
hydroponics (i.e. use of organic fertilisation and organic plant media), these bacteria
could act as antagonist agents or as plant defence elicitors to protect plants from
diseases. In the future, research on the disease suppressive ability of the aquaponic
biotope must be increased, as well as isolation, characterisation and formulation of
microbial plant pathogen antagonists. Finally, a good knowledge in the rapid
identification of pathogens, combined with control methods and diseases monitoring,
as recommended in integrated plant pest management, is the key to an efficient
control of plant diseases in aquaponics.Cos
Análisis Comparativo De Insulina Glargina Frente a Insulina Detemir: Modelo De Minimización De Costos Para Colombia
Enfermedad de hansen (lepra): Eritema nodoso leproso presentación de caso
Hansen's disease or leprosy is a chronic course infectious disease as old as humanity itself, which throughout history has led to the isolation and alienation of anyone who has it. Nowadays due to pathogenesis knowledge and therapeutics advance we can have a different point of view about it. In the following sections we will perform an updated revision of this disease and check a 44 year-old patient case, who was diagnosed with lepromatous leprosy developing a nodosum leprosum erythema and who has also received the appropriate multidrug treatment with appropriate clinical response.La enfermedad de Hansen o lepra es una enfermedad infectocontagiosa de curso crónico tan antigua como la humanidad misma, que a lo largo de la historia ha marginado a todo aquel que la padece. En la actualidad con el conocimiento de su patogenia y avances en la terapéutica se tiene una visión diferente de la misma. En los siguientes párrafos se realiza una revisión bibliográfica actualizada y la presentación del caso clínico de un paciente de 44 años de edad, al cual se le diagnostico lepra lepromatosa con desarrollo de eritema nodoso leproso quien recibió manejo poliquimioterapéutico con adecuada evolución
Dr. Russell West Talking with Students - 4
Dr. Russell West talking with students after class.https://place.asburyseminary.edu/communications/2847/thumbnail.jp
Serum Levels of Myonectin Are Lower in Adults with Metabolic Syndrome and Are Negatively Correlated with Android Fat Mass
Myonectin has shown beneficial effects on lipid regulation in murine models; therefore, it may have implications in the pathophysiology of metabolic syndrome (MS). We evaluated the relationship between serum myonectin and serum lipids, global and regional fat mass, intramuscular lipid content, and insulin resistance (IR) in adults with metabolic risk factors. This was a cross-sectional study in sedentary adults who were diagnosed with MS or without MS (NMS). Serum myonectin was quantified by enzyme-linked immunosorbent assay, lipid profile by conventional techniques, and free fatty acids (FFA) by gas chromatography. Body composition was assessed by dual-energy X-ray absorptiometry and intramuscular lipid content through proton nuclear magnetic resonance spectroscopy in the right vastus lateralis muscle. IR was estimated with the homeostatic model assessment (HOMA-IR). The MS (n = 61) and NMS (n = 29) groups were comparable in age (median (interquartile range): 51.0 (46.0–56.0) vs. 53.0 (45.5–57.5) years, p > 0.05) and sex (70.5% men vs. 72.4% women). MS subjects had lower serum levels of myonectin than NMS subjects (1.08 (0.87–1.35) vs. 1.09 (0.93–4.05) ng·mL−1, p 2 = 0.48, p < 0.01), but not with the lipid profile, FFA, intramuscular lipid content or HOMA-IR. In conclusion, serum myonectin is lower in subjects with MS. Myonectin negatively correlates with a component relevant to the pathophysiology of MS, such as the android/gynoid fat mass ratio, but not with other components such as FFA, intramuscular fat or IR
Almost 50 Years of Monomeric Extracellular Ubiquitin (eUb)
Monomeric ubiquitin (Ub) is a 76-amino-acid highly conserved protein found in eukaryotes. The biological activity of Ub first described in the 1970s was extracellular, but it quickly gained relevance due to its intracellular role, i.e., post-translational modification of intracellular proteins (ubiquitination) that regulate numerous eukaryotic cellular processes. In the following years, the extracellular role of Ub was relegated to the background, until a correlation between higher survival rate and increased serum Ub concentrations in patients with sepsis and burns was observed. Although the mechanism of action (MoA) of extracellular ubiquitin (eUb) is not yet well understood, further studies have shown that it may ameliorate the inflammatory response in tissue injury and multiple sclerosis diseases. These observations, compounded with the high stability and low immunogenicity of eUb due to its high conservation in eukaryotes, have made this small protein a relevant candidate for biotherapeutic development. Here, we review the in vitro and in vivo effects of eUb on immunologic, cardiovascular, and nervous systems, and discuss the potential MoAs of eUb as an anti-inflammatory, antimicrobial, and cardio- and brain-protective agent
Antioxidant and antimutagenic activities of <i>Acacia pennatula</i> pods
859-864Methanolic extracts of Acacia pennatula pods (MEA) were
screened for antioxidant and antimutagenic properties by 1,1-
diphenyl-2-picrylhydrazyl (DPPH),
2,2´-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), ferric reducing
antioxidant
power (FRAP) and Kado microsuspension assays, respectively.
Total phenolic and flavonoid contents as well as HPLC identification
and quantification of gallic acid and (+)-catechin were also
carried out. MEA were capable of significant antioxidant
capacity by DPPH, ABTS and FRAP methods. MEA inhibited >
80% mutagenicity induced either by 4-nitro-O-phenylenediamine
or sodium azide. Thus phenolics-containing extracts of A.
pennatula pods display biological activities with potential
application in pharmaceutical and food sectors