Large-scale electrophysiology and deep learning reveal distorted neural signal dynamics after hearing loss

Listeners with hearing loss often struggle to understand speech in noise, even with a hearing aid. To better understand the auditory processing deficits that underlie this problem, we made large-scale brain recordings from gerbils, a common animal model for human hearing, while presenting a large database of speech and noise sounds. We first used manifold learning to identify the neural subspace in which speech is encoded and found that it is low-dimensional and that the dynamics within it are profoundly distorted by hearing loss. We then trained a deep neural network (DNN) to replicate the neural coding of speech with and without hearing loss and analyzed the underlying network dynamics. We found that hearing loss primarily impacts spectral processing, creating nonlinear distortions in cross-frequency interactions that result in a hypersensitivity to background noise that persists even after amplification with a hearing aid. Our results identify a new focus for efforts to design improved hearing aids and demonstrate the power of DNNs as a tool for the study of central brain structures

PRETTY: Grazing altimetry measurements based on the interferometric method

The exploitation of signals stemming from global navigation systems for passive bistatic radar applications has beenproposed and implemented within numerous studies. The fact that such missions do not rely on high power amplifiersand that the need of high gain antennas with large geometrical dimensions can be avoided, makes them suitable forsmall satellite missions. Applications where a continuous high coverage is needed, as for example disaster warning,have the demand for a large number of satellites in orbit, which in turn requires small and relatively low cost satellites.The proposed PRETTY (Passive Reflectometry and Dosimetry) mission includes a demonstrator payload for passivereflectometry and scatterometry focusing on very low incidence angles whereby the direct and reflected signal will bereceived via the same antenna. The correlation of both signals will be done by a specific FPGA based hardwareimplementation. The demonstration of a passive reflectometer without the use of local code replica implicitly showsthat also signals of unknown data modulation can be exploited for such a purpose.The PRETTY mission is proposed by an Austrian consortium with RUAG GmbH as prime contractor, relying on theresults from a previous CubeSat mission (OPS-SAT) conducted by TU Graz under ESA contract [18]. Within thepresent paper we will describe the architecture of the passive reflectometer payload within this 3U CubeSat mission anddiscuss operational routines and constraints to be elaborated in the frame of the proposed activity

City branding as economic necessity

Kvalitetno brendiranje grada je preduvjet za njihovu prepoznatljivost, kvalitetno pozicioniranje i stvaranje dodatne vrijednosti. Praksa i mnogobrojni primjeri potvrđuju ispravnost ove teze. Brendiranje gradova je nužno kako bi se pojačala konkurentnost, ostvarila veća dobit i osigurao razvoj mjesta. No ne radi se samo o ekonomskim kategorijama jer se pod razvojem mjesta podrazumijevaju i pozitivna demografska kretanja, obogaćivanje kulturnih sadržaja kao i drugih činitelja koji podižu ukupnu kvalitetu života. Izazov je to i nužnost i za gradove u Hrvatskoj kako bi bili konkurentni u oštroj tržišnoj konkurenciji.Quality city branding is a precondition for their recognazibility, quality positionig and creating of added value. Practice and numerous examples confirm correction of this theses. City branding is necessary to enhance concurence, gain bigger profit and ensure place development. But this is not only about economic categories because under place development it is understandable alsto positive demographic movement, enrichment of cultural contens as well as other factors which raise total quality of life. This is as well a challenge as it is a necessity for cities in Croatia so they could be concurente in harsh economy concurence

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Coupling superconducting Qubits to tunable cavities and resolving the circuit QED Lamb shift

This thesis discusses the realization of a solid-state, electrical circuit analog of atomic cavity quantum electrodynamics in which a superconducting charge qubit is strongly coupled to a coherent microwave radiation field contained in a high quality factor transmission line resonator, an architecture that has become to be known as circuit quantum electrodynamics (QED). This system allows studying the interaction of individual photons with an artificial atom and to perform fundamental quantum optics experiments on an electrical chip.Moreover, it has a strong, demonstrated potential for the implementation of a solid-state quantum information processor.In the framework of this thesis, two major experiments have been carried out in the circuit QED architecture. First, on-chip quantum optics experiments are presented in which we were able to investigate the interaction of matter and light down to the level of single quanta, ultimately reaching the limit where a superconducting qubit dispersively interacts with the pure vacuum fluctuations of the electromagnetic cavity field. Here, the presence of virtual photons manifests itself as a small renormalization of the energy of the qubit in the form of the Lamb shift, which is observed in our experiments for the first time in a solid-state system. The transition from the strong dispersive to the resonant strong interaction is shown as a smooth, continuous overlap of cavity transmission and qubit spectroscopy data, in a region where the Lamb shift turns into the vacuum Rabi splitting of the cavity-qubit superposition states. The enhancement by the cavity leads to maximum observable Lamb shifts of up to 1.4% relative to the qubit transition frequency. Following the vacuum field measurements, the photon number is subsequently increased. In this regime, some interesting results will be presented that allow us to put the Lamb shift in a consistent picture and to resolve individual photon number states of the cavity.The second part of this thesis focuses on the development of a novel type of transmission line resonator. As opposed to conventional circuit QED cavities, the resonance frequency of these devices can be dynamically tuned with an external magnetic field. Flux-tunable transmission line resonators are systematically investigated in this thesis, ranging from a thorough theoretical analysis to detailed experimental studies in which the tuning behavior of both the resonance frequency as well as the quality factor is determined. Large tuning ranges of up to 2.5 GHz are observed and it is shown that the behavior of the quality factor can be controlled by choosing adequate design parameters. Finally, first experiments are presented in which we demonstrate the successful strong coupling of a superconducting transmon qubit to a flux-tunable cavity.11

Development of a Miniaturized Reference Dosimeter Payload for SmallSat Applications

We present the TID Reference Dosimeter and SEU Assessment System, an autonomous, miniaturized dosimetry payload for SmallSat applications. We provide information on the concept, performance and the current status of its development, including preparations for the payload’s first in-orbit demonstration onboard the Austrian CubeSat PRETTY