Possible splitting of deconfinement and chiral transitions in strong magnetic fields in QCD

We show that finite-temperature deconfinement and chiral transitions can split in a strong enough magnetic field. The splitting in critical temperatures of these transitions in a constant magnetic field of a typical LHC magnitude is of the order of 10 MeV. A new deconfined phase with broken chiral symmetry appears.Comment: 4 pages, 6 figures; talk given by E. S. Fraga at 35th International Conference of High Energy Physics (ICHEP 2010), July 22-28, 2010, Paris, Franc

Coastal and marine protected areas in Mexico

This study on marine protected areas (MPAs) in Mexico relies on a variety of data sources as well as the authors’ longstanding field experience, particularly in the Yucatan Peninsula, to analyze the design, establishment and operation of protected areas. It discusses two case studies of MPAs in detail and summarizes the findings from four others, focusing primarily on the role played by local communities in managing coastal and marine resources. The study also draws on the perspective of key informants, namely, Mexican experts on coastal and ocean management issues, including government officials, decisionmakers, researchers, members of non governmental organizations (NGOs), and consultants. (97 pp.

Declaratoria de una plataforma de trabajo en red en el marco de la Primera Conferencia Internacional experiencias de redes, equipos y cuerpos académicos en el contexto del turismo, patrimonio y sustentabilidad en Mérida, México (2012)

Crónica de Event

Molecular mechanisms of Zika virus teratogenesis from animal studies : a systematic review protocol

Background: Due to the diversity of studies in animal models reporting that molecular mechanisms are involved in the teratogenic effect of the Zika virus (ZIKV), the objective of the present study is to evaluate the methodological quality of these studies, as well as to demonstrate which genes and which molecular pathways are affected by ZIKV in different animal models. Methods: This search will be performed in four databases: PubMed/MEDLINE, EMBASE, Web of Science, and Scopus, as well as in the grey literature. The studies selection process will be reported through the PRISMA Statement diagram model. All studies describing the molecular mechanisms possibly involved in the development of malformations caused by embryonic/fetal ZIKV exposure in animal models with an appropriate control group and methodology will be included (including, for instance, randomized and non-randomized studies). All animals used as experimental models for ZIKV teratogenesis may be included as long as exposure to the virus occurred during the embryonic/fetal period. From the selected studies, data will be extracted using a previously prepared standard form. Bias risk evaluation will be conducted following the SYRCLE’s Risk of Bias tool. All data obtained will be tabulated and organized by outcomes (morphological and molecular). Discussion: With the proposed systematic review, we expect to present results about the methodological quality of the published studies with animal models that investigated the molecular mechanisms involved in the teratogenic effect of ZIKV, as well as to show the studies with greater reliability

Fine-Tuning Climate Resilience in Marine Socio-Ecological Systems: The Need for Accurate Space-Time Representativeness to Identify Relevant Consequences and Responses

Climate change triggers a wide mosaic of regional and local responses, often different to the large-scale variability in magnitude and direction. Because of the psychological connections (cognitive and emotional) with the frequency, intensity and age of a climatic event, people may have the capacity to recognize key variations at lower scales, especially those from which they perceive risk. Yet, the anticipatory actions and social engagement to respond or adapt to climate change are difficult to achieve, mostly when there exists a long psychological distance to climatic phenomena. Research about climate change communication provides clues about the relevance of place-based discussion to gauge risk perception and improve response protocols, their design and prioritization. It argues that strategies and actions required to face climate risks may widely differ depending on the scale and accuracy of the local representations displayed during discussions of climate impacts. This work examines how local attributes (from climate to social) operate and control place-specific risks and priorities, by comparing coastal communities in two locations, Cabo Pulmo, Mexico and Zanzibar, Tanzania, which are subject to different climate dynamics. This paper discusses the need to identify relevant climate risks/responses at the local level and how psycho-social factors (e.g., psychological distance, collective memory, and social engagement) may operate positively for building climate resilience. We also illustrate a workflow to increase and enhance collaboration between researchers and local people by promoting dialogue, participation and narratives that rigorously consider the local knowledge

Covid-19, impactos económicos y socio-ecológicos en tres comunidades de pescadores artesanales en Yucatán

Yucatán, estado mexicano ubicado en la península del mismo nombre, cuenta con 378 kilómetros de litoral, conformado por quince puertos, albergando aproximadamente cien mil habitantes dedicados culturalmente a la pesca artesanal; la cadena productiva de la pesca artesanal de esta región consiste en la extracción, comercialización y una transformación incipiente. Ante la pandemia del Covid-19, gobierno y pobladores cerraron accesos a los puertos, limitando incluso entradas de insumos y víveres, los recursos marinos como bienes comunes representaron una fuente nutrimental importante que reforzó el vínculo cultural mar-comunidad. La economía costera sufrió afectaciones, pues su economía depende de la comercialización pesquera. El presente estudio analiza el impacto de la pandemia desde un enfoque cualitativo, abordando: Cambios derivados de la pandemia, adaptaciones socio-económicas, culturales y sanitarias, así como la presión hacia los recursos marino-costeros, todo en el marco de bienes comunes propuesto por Elinor Ostrom. Se reflexionó acerca de ¿Cómo percibe el pescador los cambios culturales, económicos y sanitarios en su actividad por la pandemia? Y su visión del futuro de la pesca artesanal. La metodología utilizada para el análisis de la información fue la Fenomenología. Las narraciones se obtuvieron mediante entrevistas telefónicas semiestructuradas durante el mes de julio 2020 aplicadas a 45 pescadores del portafolio de directorios construidos en la labor costera en Celestún, Sisal y San Felipe. Objetivo: expresar las principales afectaciones al pescador ocasionados por la pandemia, tomando como base los imaginarios de los pescadores y su implemantación de estrategias para superar la crisis. Lo que nos llevó a concluir que los principales impactos han sido los económicos por el cierre de las exportaciones, lo que demuestra una fuerte dependencia del pescador artesanal a los mercados internacionales, sin embargo, el ingenio del pescador de bajura, le ha ayudado a diseñar e implementar estrategias resilientes encontrando nuevos medios y mercados para comercializar sus bienes dando un paso hacía la economía circular y a la reactivación de la economía regional

The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis

Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy. The complete understanding of the mechanisms by which thalidomide afects the embryo development has not yet been obtained. The phenotypic similarity makes TE a phenocopy of syndromes caused by mutations in ESCO2, SALL4 and TBX5 genes. Recently, SALL4 and TBX5 were demonstrated to be thalidomide targets. To understand if these genes act in the TE development, we sequenced them in 27 individuals with TE; we verifed how thalidomide afect them in human pluripotent stem cells (hPSCs) through a diferential gene expression (DGE) analysis from GSE63935; and we evaluated how these genes are functionally related through an interaction network analysis. We identifed 8 variants in ESCO2, 15 in SALL4 and 15 in TBX5. We compared allelic frequencies with data from ExAC, 1000 Genomes and ABraOM databases; eight variants were signifcantly diferent (p<0.05). Eleven variants in SALL4 and TBX5 were previously associated with cardiac diseases or malformations; however, in TE sample there was no association. Variant efect prediction tools showed 97% of the variants with potential to infuence in these genes regulation. DGE analysis showed a signifcant reduction of ESCO2 in hPSCs after thalidomide exposure

CRL4-Cereblon complex in Thalidomide Embryopathy : a translational investigation

The Cereblon-CRL4 complex has been studied predominantly with regards to thalidomide treatment of multiple myeloma. Nevertheless, the role of Cereblon-CRL4 in Thalidomide Embryopathy (TE) is still not understood. Not all embryos exposed to thalidomide develop TE, hence here we evaluate the role of the CRL4-Cereblon complex in TE variability and susceptibility. We sequenced CRBN, DDB1, CUL4A, IKZF1, and IKZF3 in individuals with TE. To better interpret the variants, we suggested a score and a heatmap comprising their regulatory effect. Differential gene expression after thalidomide exposure and conservation of the CRL4-Cereblon protein complex were accessed from public repositories. Results suggest a summation effect of Cereblon variants on pre-axial longitudinal limb anomalies, and heatmap scores identify the CUL4A variant rs138961957 as potentially having an effect on TE susceptibility. CRL4-Cereblon gene expression after thalidomide exposure and CLR4-Cereblon protein conservation does not explain the difference in Thalidomide sensitivity between species. In conclusion, we suggest that CRL4-Cereblon variants act through several regulatory mechanisms, which may influence CRL4-Cereblon complex assembly and its ability to bind thalidomide. Human genetic variability must be addressed not only to further understand the susceptibility to TE, but as a crucial element in therapeutics, including in the development of pharmacogenomics strategies

A new strategy for the old challenge of thalidomide : systems biology prioritization of potential immunomodulatory drug (IMiD)-targeted transcription factors

Several molecular mechanisms of thalidomide embryopathy (TE) have been investigated, from anti-angiogenesis to oxidative stress to cereblon binding. Recently, it was discovered that thalidomide and its analogs, named immunomodulatory drugs (IMiDs), induced the degradation of C2H2 transcription factors (TFs). This mechanism might impact the strict transcriptional regulation of the developing embryo. Hence, this study aims to evaluate the TFs altered by IMiDs, prioritizing the ones associated with embryogenesis through transcriptome and systems biology-allied analyses. This study comprises only the experimental data accessed through bioinformatics databases. First, proteins and genes reported in the literature as altered/affected by the IMiDs were annotated. A protein systems biology network was evaluated. TFs beta-catenin (CTNNB1) and SP1 play more central roles: beta-catenin is an essential protein in the network, while SP1 is a putative C2H2 candidate for IMiDinduced degradation. Separately, the differential expressions of the annotated genes were analyzed through 23 publicly available transcriptomes, presenting 8624 differentially expressed genes (2947 in two or more datasets). Seventeen C2H2 TFs were identified as related to embryonic development but not studied for IMiD exposure; these TFs are potential IMiDs degradation neosubstrates. This is the first study to suggest an integration of IMiD molecular mechanisms through C2H2 TF degradation

Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy

The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain. The aim of this study was to detect sequence divergences between species, affected or not by TE, and to evaluate the regulated gene co-expression in a murine model. Here, we performed a comparative analysis of proteins experimentally established as affected by thalidomide exposure, evaluating 14 species. The comparative analysis, regarding synteny, neighborhood, and protein conservation, was performed in 42 selected genes. Differential co-expression analysis was performed, using a publicly available assay, GSE61306, which evaluated mouse embryonic stem cells (mESC) exposed to thalidomide. The comparative analyses evidenced 20 genes in the upstream neighborhood of NOS3, which are different between the species who develop, or not, the classic TE phenotype. Considering protein sequence alignments, RECQL4, SALL4, CDH5, KDR, and NOS2 proteins had the biggest number of variants reported in unaffected species. In co-expression analysis, Crbn was a gene identified as a driver of the co-expression of other genes implicated in genetic, non-teratogenic, limb reduction defects (LRD), such as Tbx5, Esco2, Recql4, and Sall4; Crbn and Sall4 were shown to have a moderate co-expression correlation, which is affected after thalidomide exposure. Hence, even though the classic TE phenotype is not identified in mice, a deregulatory Crbn-induced mechanism is suggested in this animal. Functional studies are necessary, especially evaluating the genes responsible for LRD syndromes and their interaction with thalidomide–Cereblon