272 research outputs found

    Fluctuation regimes of soil moisture in ERA-40 re-analysis data

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    Soil moisture variability is analysed in the re-analysis data ERA-40 of the European Centre for Medium-Range Weather Forecasts (ECMWF) which includes four layers within 189 cm depth. Short-term correlations are characterised by an e-folding time scale assuming an exponential decay, whilst long-term memory is described by power law decays with exponents determined by detrended fluctuation analysis. On a global scale, the short-term variability varies congruently with long-term memory in the surface layer. Key climatic regions (Europe, Amazon and Sahara) reveal that soil moisture time series are non-stationary in arid regions and in deep layers within the time horizon of ERA-40. The physical processes leading to soil moisture variability are linear according to an analysis of volatility (the absolute differences), which is substantiated by surrogate data analysis preserving the long-term memory

    Carotid stenting: is there an operator effect? A pooled analysis from the carotid stenting trialists' collaboration.

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    BACKGROUND AND PURPOSE: Randomized clinical trials show higher 30-day risk of stroke or death after carotid artery stenting compared with surgery. We examined whether operator experience is associated with 30-day risk of stroke or death in the Carotid Stenting Trialists' Collaboration database. METHODS: The Carotid Stenting Trialists' Collaboration is a pooled individual patient database including all patients recruited in 3 randomized trials of stenting versus endarterectomy for symptomatic carotid stenosis (Endarterectomy Versus Angioplasty in patients with Symptomatic Severe Carotid Stenosis trial, Stent-Protected Angioplasty versus Carotid Endarterectomy trial, and International Carotid Stenting Study). Lifetime carotid artery stenting experience, lifetime experience in stenting procedures excluding the carotid, and annual number of procedures performed within the trial (in-trial volume), divided into tertiles, were used to measure operator experience. The outcome event was the occurrence of any stroke or death within 30 days of the procedure. The analysis was done per protocol. RESULTS: Among 1546 patients who underwent carotid artery stenting, 120 (7.8%) had a stroke or death within 30 days of the procedure. The 30-day risk of stroke or death did not differ according to operator lifetime carotid artery stenting experience (P=0.8) or operator lifetime stenting experience excluding the carotid (P=0.7). In contrast, the 30-day risk of stroke or death was significantly higher in patients treated by operators with low (mean ≤3.2 procedures/y; risk 10.1%; adjusted risk ratio=2.30 [1.36-3.87]) and intermediate annual in-trial volumes (3.2-5.6 procedures/y; 8.4%; adjusted risk ratio=1.93 [1.14-3.27]) compared with patients treated by high annual in-trial volume operators (>5.6 procedures/y; 5.1%). CONCLUSIONS: Carotid stenting should only be performed by operators with annual procedure volume ≥6 cases per year

    Power-law persistence and trends in the atmosphere: A detailed study of long temperature records

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    We use several variants of the detrended fluctuation analysis to study the appearance of long-term persistence in temperature records, obtained at 95 stations all over the globe. Our results basically confirm earlier studies. We find that the persistence, characterized by the correlation C(s) of temperature variations separated by s days, decays for large s as a power law, C(s) ~ s^(-gamma). For continental stations, including stations along the coastlines, we find that gamma is always close to 0.7. For stations on islands, we find that gamma ranges between 0.3 and 0.7, with a maximum at gamma = 0.4. This is consistent with earlier studies of the persistence in sea surface temperature records where gamma is close to 0.4. In all cases, the exponent gamma does not depend on the distance of the stations to the continental coastlines. By varying the degree of detrending in the fluctuation analysis we obtain also information about trends in the temperature records.Comment: 5 pages, 4 including eps figure

    Absence of Consistent Sex Differences in Outcomes From Symptomatic Carotid Endarterectomy and Stenting Randomized Trials.

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    BACKGROUND AND PURPOSE: CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) reported a higher periprocedural risk for any stroke, death, or myocardial infarction for women randomized to carotid artery stenting (CAS) compared with women randomized to carotid endarterectomy (CEA). No difference in risk by treatment was detected for women relative to men in the 4-year primary outcome. We aimed to conduct a pooled analysis among symptomatic patients in large randomized trials to provide more precise estimates of sex differences in the CAS-to-CEA risk for any stroke or death during the 120-day periprocedural period and ipsilateral stroke thereafter. METHODS: Data from the Carotid Stenosis Trialists' Collaboration included outcomes from symptomatic patients in EVA-3S (Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis), SPACE (Stent-Protected Angioplasty Versus Carotid Endarterectomy in Symptomatic Patients), ICSS (International Carotid Stenting Study), and CREST. The primary outcome was any stroke or death within 120 days after randomization and ipsilateral stroke thereafter. Event rates and relative risks were estimated using Poisson regression; effect modification by sex was assessed with a sex-by-treatment-by-trial interaction term, with significant interaction defined a priori as P≤0.10. RESULTS: Over a median 2.7 years of follow-up, 433 outcomes occurred in 3317 men and 1437 women. The CAS-to-CEA relative risk of the primary outcome was significantly lower for women compared with men in 1 trial, nominally lower in another, and nominally higher in the other two. The sex-by-treatment-by-trial interaction term was significant (P=0.065), indicating heterogeneity among trials. Contributors to this heterogeneity are primarily differences in periprocedural period. When the trials are nevertheless pooled, there were no significant sex differences in risk in any follow-up period. CONCLUSIONS: There were significant differences between trials in the magnitude of sex differences in treatment effect (CAS-to-CEA relative risk), indicating pooling data from these trials to estimate sex differences might not be valid. Whether sex is acting as an effect modifier of the CAS-to-CEA treatment effect in symptomatic patients remains uncertain. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00190398 (EVA-3S) and NCT00004732 (CREST). URL: https://www.isrctn.com; Unique identifier: ISRCTN57874028 (SPACE) and ISRCTN25337470 (ICSS)

    Intercomparison of the northern hemisphere winter mid-latitude atmospheric variability of the IPCC models

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    We compare, for the overlapping time frame 1962-2000, the estimate of the northern hemisphere (NH) mid-latitude winter atmospheric variability within the XX century simulations of 17 global climate models (GCMs) included in the IPCC-4AR with the NCEP and ECMWF reanalyses. We compute the Hayashi spectra of the 500hPa geopotential height fields and introduce an integral measure of the variability observed in the NH on different spectral sub-domains. Only two high-resolution GCMs have a good agreement with reanalyses. Large biases, in most cases larger than 20%, are found between the wave climatologies of most GCMs and the reanalyses, with a relative span of around 50%. The travelling baroclinic waves are usually overestimated, while the planetary waves are usually underestimated, in agreement with previous studies performed on global weather forecasting models. When comparing the results of various versions of similar GCMs, it is clear that in some cases the vertical resolution of the atmosphere and, somewhat unexpectedly, of the adopted ocean model seem to be critical in determining the agreement with the reanalyses. The GCMs ensemble is biased with respect to the reanalyses but is comparable to the best 5 GCMs. This study suggests serious caveats with respect to the ability of most of the presently available GCMs in representing the statistics of the global scale atmospheric dynamics of the present climate and, a fortiori, in the perspective of modelling climate change.Comment: 39 pages, 8 figures, 2 table

    Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled Trials.

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    OBJECTIVE: Current guidelines recommending rapid revascularisation of symptomatic carotid stenosis are largely based on data from clinical trials performed at a time when best medical therapy was potentially less effective than today. The risk of stroke and its predictors among patients with symptomatic carotid stenosis awaiting revascularisation in recent randomised controlled trials (RCTs) and in medical arms of earlier RCTs was assessed. METHODS: The pooled data of individual patients with symptomatic carotid stenosis randomised to stenting (CAS) or endarterectomy (CEA) in four recent RCTs, and of patients randomised to medical therapy in three earlier RCTs comparing CEA vs. medical therapy, were compared. The primary outcome event was any stroke occurring between randomisation and treatment by CAS or CEA, or within 120 days after randomisation. RESULTS: A total of 4 754 patients from recent trials and 1 227 from earlier trials were included. In recent trials, patients were randomised a median of 18 (IQR 7, 50) days after the qualifying event (QE). Twenty-three suffered a stroke while waiting for revascularisation (cumulative 120 day risk 1.97%, 95% confidence interval [CI] 0.75 - 3.17). Shorter time from QE until randomisation increased stroke risk after randomisation (χ2 = 6.58, p = .011). Sixty-one patients had a stroke within 120 days of randomisation in the medical arms of earlier trials (cumulative risk 5%, 95% CI 3.8 - 6.2). Stroke risk was lower in recent than earlier trials when adjusted for time between QE and randomisation, age, severity of QE, and degree of carotid stenosis (HR 0.47, 95% CI 0.25 - 0.88, p = .019). CONCLUSION: Patients with symptomatic carotid stenosis enrolled in recent large RCTs had a lower risk of stroke after randomisation than historical controls. The added benefit of carotid revascularisation to modern medical care needs to be revisited in future studies. Until then, adhering to current recommendations for early revascularisation of patients with symptomatic carotid stenosis considered to require invasive treatment is advisable

    Проектирование контактора постоянного тока для коммутации цепи привода экскаватора

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    РЕФЕРАТ Выпускная квалификационная работа включает в себя 90 страниц, 22 рисунка, 11 таблиц, 119 формул, 24 источника. Объект исследования — контактор постоянного тока. Цель работы заключается в проектировании контактора постоянного тока для коммутации цепи привода экскаватора на заданные параметры тока, напряжения и режима работы. Для достижения этой цели, необходимо решить следующие задачи: •выбор прототипа контактора постоянного тока; •расчет токоведущего контура; •расчет дугогасительного устройства; •расчет механической характеристики; •расчет электромагнитной системы. Результатом проведенной работы является спроектированный контактор постоянного тока.ESSAY Final qualifying work includes 90 pages, 22 figures, 11 tables, 119 formulas, 24 source. The object of study - DC contactor. The aim of the work is to design a DC contactor for switching chain excavator drive on given current parameters, voltage and operating mode. To achieve this goal, you need to solve the following problems: • Selection of a prototype DC contactor; • calculation of the current-carrying path; • calculation Interrupters; • calculation of the mechanical characteristics; • calculation of electromagnetic systems. The result of this work is designed DC contactor

    Forecasting the underlying potential governing the time series of a dynamical system

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    Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.We introduce a technique of time series analysis, potential forecasting, which is based on dynamical propagation of the probability density of time series. We employ polynomial coefficients of the orthogonal approximation of the empirical probability distribution and extrapolate them in order to forecast the future probability distribution of data. The method is tested on artificial data, used for hindcasting observed climate data, and then applied to forecast Arctic sea-ice time series. The proposed methodology completes a framework for ‘potential analysis’ of tipping points which altogether serves anticipating, detecting and forecasting nonlinear changes including bifurcations using several independent techniques of time series analysis. Although being applied to climatological series in the present paper, the method is very general and can be used to forecast dynamics in time series of any origin.NERCAXA Research FundEuropean Commissio
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