Exploring Sustainability Implications of Transitions to Agroecology: a Transdisciplinary Perspective

Successful transitions to agroecology require shared understanding of the sustainability implications of transitions for food systems. To gain such understanding, a transdisciplinary approach is increasingly called for by funders, end users of research and scientists. Transdisciplinary processes were used in the UNISECO project to develop strategic pathways that enable transitions to agroecology in case studies across Europe. These strategic pathways were combined with scenarios of EU food systems in 2050, in which combinations of agroecological farming and food consumption practices were assessed. These were then reviewed considering selected UN Sustainable Development Goals (SDGs) as a reference for discussing the sustainability implications of transitions to agroecology. Sustainability implications were identified for several SDGs including Zero Hunger (SDG 2), Quality Education (SDG 4), Responsible Consumption and Production (SDG 12), Climate Action (SDG 13) and Life on Land (SDG 15). Key factors contributing to the sustainability of transitions to agroecology are: i) mature social capital and improved farmer knowledge of the benefits of agroecological practices; ii) strengthened collaborative actions and collective institutions to increase negotiating power within the value-chain; and, iii) changes in consumer behaviour and diets. These factors highlight the need for a food system perspective in transitions to agroecology and supporting policies. This in turn highlights the meaningful role of transdisciplinary research in strengthening the sustainability of European food systems

Tumor Lysis Syndrome: An Endless Challenge in Onco-Nephrology

Tumor lysis syndrome (TLS) is a common cause of acute kidney injury in patients with malignancies, and it is a frequent condition for which the nephrologist is consulted in the case of the hospitalized oncological patient. Recognizing the patients at risk of developing TLS is essential, and so is the prophylactic treatment. The initiation of treatment for TLS is a medical emergency that must be addressed in a multidisciplinary team (oncologist, nephrologist, critical care physician) in order to reduce the risk of death and that of chronic renal impairment. TLS can occur spontaneously in the case of high tumor burden or may be caused by the initiation of highly efficient anti-tumor therapies, such as chemotherapy, radiation therapy, dexamethasone, monoclonal antibodies, CAR-T therapy, or hematopoietic stem cell transplantation. It is caused by lysis of tumor cells and the release of cellular components in the circulation, resulting in electrolytes and metabolic disturbances that can lead to organ dysfunction and even death. The aim of this paper is to review the scientific data on the updated definition of TLS, epidemiology, pathogenesis, and recognition of patients at risk of developing TLS, as well as to point out the recent advances in TLS treatment