Beyond Transgression: Toward a Free Market in Morality

Richard A. Posner. Sex and Reason. Cambridge: Harvard University Press, 1992. Pp. vii, 458. $29.95. With his special gift for contrariety, Judge Richard Posner places his ambitious investigation of the vicissitudes of sex under the aegis of a quote from Aristotle\u27s Nicomachean Ethics: Pleasures are an impediment to rational deliberation, and the more so the more pleasurable they are, such as the pleasures of sex - it is impossible to think about anything while absorbed in them. Posner then devotes the ensuing 442 dense pages to challenging Aristotle\u27s assertion. That sex and reason normally make incompatible bedfellows should not be taken as evidence that it is impossible to subject sex to the rigors of reason. Sex, Posner suggests throughout the book, must be considered as one form of behavior among many, no more nor less immune to the operations of the rational mind. Posner\u27s commitment to the power of rationality, as he understands it, constitutes the great strength and ultimate weakness of his work. And it is easy to imagine that many readers will find his rational foray into sex infuriating. He has no patience for the facile confusion of sex with passion, much less of sex with desire, which so mesmerizes contemporary critics. Posner\u27s discussion of sex has more to do with theories of animal behavior than with the feelings of individuals. In this respect the great strength of Posner\u27s book overlaps with its most disturbing weakness, namely, his determination to organize complex human behavior in predictable- and largely determined-patterns

Warfare And Word Play: A Postmodernist Rendering Of Civil War Memory And Literature

In Disarming the Nation, Elizabeth Young seeks to rectify the prevailing vision of the Civil War as a male exercise in nation build-ing and to discredit the prevailing view of the literature about it as a complemen-tary story of patrilineal self-generation. Deploring the myth of origins ...

Translation Studies versus Comparative Literature?

Comparative literature is one of the main disciplines out of which translation studies emerged, so it is hardly surprising if at times the relationship between the two subjects has been marked by antagonism. Comparative literary scholars, in particular – perennially anxious about the status of comparative literature itself – have argued that their discipline has been subsumed and superseded by translation studies. Yet in recent decades the two subject areas have also been growing further apart, to the extent that Susan Bassnett, one of the key exponents of the antagonistic view, has modified her stance and argued instead for a rapprochement between the two under the heading of intercultural studies

Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function

Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10−7) and FNDC1 (p-value = 3.0×10−7) for UACR, and KCNQ1 with eGFR (p = 3.6×10−6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish

Reflections on the 'History and Historians' of the black woman's role in the community of slaves: enslaved women and intimate partner sexual violence

Taking as points of inspiration Peter Parish’s 1989 book, Slavery: History and Historians, and Angela Davis’s seminal 1971 article, “Reflections on the black woman’s role in the community of slaves,” this probes both historiographically and methodologically some of the challenges faced by historians writing about the lives of enslaved women through a case study of intimate partner violence among enslaved people in the antebellum South. Because rape and sexual assault have been defined in the past as non-consensual sexual acts supported by surviving legal evidence (generally testimony from court trials), it is hard for historians to research rape and sexual violence under slavery (especially marital rape) as there was no legal standing for the rape of enslaved women or the rape of any woman within marriage. This article suggests enslaved women recognized that black men could both be perpetrators of sexual violence and simultaneously be victims of the system of slavery. It also argues women stoically tolerated being forced into intimate relationships, sometimes even staying with “husbands” imposed upon them after emancipation

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