Phonologische Prozesse in der deutschen Sprache türkisch-deutsch bilingualer Kinder [Phonological patterns in German in Turkish-German bilingual children]

Hintergrund Kenntnisse über den typischen Ausspracheerwerb sind notwendig, um Aussprachestörungen identifizieren zu können. Hierbei spielt die phonologische Prozessanalyse eine wichtige Rolle. Informationen zum Ausspracheerwerb bilingualer Kinder sind bislang rar, sodass eine Diagnosestellung erschwert ist. Methode Mit Hilfe eines Bilderbenenntests wurden die phonologischen Prozesse im Deutschen von 84 türkisch-deutsch bilingualen Kindern im Alter von 3;0-5;5 Jahren untersucht. Ergebnis Bis auf wenige Ausnahmen (z.B. Vokalfehler) wurden nur phonologische Prozesse im Deutschen beobachtet, die denen monolingualer Kinder entsprechen. Diese wurden meist später als von monolingualen Kindern überwunden. Simultan und sukzessiv bilingual aufwachsende Kinder unterschieden sich hier kaum. Diskussion Die Ergebnisse bestätigen bisherige Pilotstudien zum türkisch-deutschen Phonologieerwerb und können zur Orientierung in der sprachtherapeutischen Aussprachediagnostik herangezogen werden. Background A reliable identification of speech sound disorders (SSD) requires detailed knowledge about the typical speech acquisition process, specifically about phonological patterns. To date, data on speech acquisition in bilingual populations are rare, which hinders the diagnostic process with regard to SSDs in bilingual children. Methods Eighty-four typically developing children growing up bilingual Turkish-German (aged 3;0-5;5) were assessed on a picture naming test for German in order to investigate the occurring phonological patterns. Results Excluding very few exceptions (e.g. vowel errors), the Turkish-German-speaking participants mainly showed error patterns in German that are typical for monolingual children acquiring German but with a later age of suppression. Differences between children growing up simultaneous bilingual or successive bilingual were minimal. Discussion The present findings concerning phonological acquisition in Turkish-German bilinguals confirm previous pilot studies and could be used as preliminary clinical guidance when diagnosing SSDs in Turkish-German bilingual children

Benefits and concerns associated with Aerobic Treatment Systems (ATS)

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Patterns in German /ʃC/-cluster acquisition

This study reports on the developmental patterns of /ʃC/ clusters in 145 normally developing monolingual German-speaking children between 2;00 and 2;11. All children completed a picture naming task to allow a systematic qualitative analysis of the production patterns. Children’s reductions of target /ʃC/clusters are examined and are evaluated with respect to two models, ‘factorial typology’ and ‘headedness’, to account for them. The results reveal expected patterns of C2 retention for ‘/ʃ/+[−continuant]’ (e.g. ‘/ʃ/+stop’ and ‘/ʃ/+nasal’) targets, and a rather indeterminate pattern for /ʃl/ and /ʃʁ/. The results for /ʃv/, a clear-cut preference of C2 retention, were rather unexpected, as the C2 is a [+continuant]. The explanation offered for the retention of /v/ is related to a place constraint. The study also examines the data from children who reached an advanced stage of cluster formation with differential targets. More specifically, in several children, one target, /ʃv/, is found to have stayed behind in the reduction phase while all others have advanced to the ‘cluster stage’. Neither the type nor the token frequencies seem satisfactory in accounting for the specific behaviour of /ʃv/. The explanation offered for the uniqueness of this target may be its non-abidence to the Sonority Sequencing Principle (SSP) because of its flat sonority and the Obligatory Contour Principle (OCP) [continuant], because of the unchanging ‘continuance’ which is demanded by the OCP. Theoretical and clinical implications are discussed

Quasi Harmonic Lattice Dynamics and Molecular Dynamics calculations for the Lennard-Jones solids

We present Molecular Dynamics (MD), Quasi Harmonic Lattice Dynamics (QHLD) and Energy Minimization (EM) calculations for the crystal structure of Ne, Ar, Kr and Xe as a function of pressure and temperature. New Lennard-Jones (LJ) parameters are obtained for Ne, Kr and Xe to reproduce the experimental pressure dependence of the density. We employ a simple method which combines results of QHLD and MD calculations to achieve densities in good agreement with experiment from 0 K to melting. Melting is discussed in connection with intrinsic instability of the solid as given by the QHLD approximation. (See http://www.fci.unibo.it/~valle for related papers)Comment: 7 pages, 5 figures, REVte

Ferroelectricity in Perovskitelike NaCaF3 Predicted Ab Initio

The ability of zero-stress simulations, using Gordon-Kim pair potentials, to describe the structures and transformations of known fluoride-based perovskites is demonstrated for the case of KCaF3. When K+ is replaced by Na+ a new ferroelectric crystal isomorphous with LiNbO3 is predicted. The equivalent relationships of the ferroelectric lithium niobate structure with the perovskite and antiperovskite structures are examined. A polarization of 21 jµC/cm2 at room temperature and a transition temperature of 550 K are predicted for NaCaF3. Surface effects are examined in simulations of a 1080-ion cluster

Origin of the Diversity in DNA Recognition Domains in Phasevarion Associated modA Genes of Pathogenic Neisseria and Haemophilus influenzae

Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of multiple genes and constitutes a phasevarion (phase variable regulon). ModA of Neisseria and Haemophilus influenzae contain a highly variable, DNA recognition domain (DRD) that defines the target sequence that is modified by methylation and is used to define modA alleles. 18 distinct modA alleles have been identified in H. influenzae and the pathogenic Neisseria. To determine the origin of DRD variability, the 18 modA DRDs were used to search the available databases for similar sequences. Significant matches were identified between several modA alleles and mod gene from distinct bacterial species, indicating one source of the DRD variability was via horizontal gene transfer. Comparison of DRD sequences revealed significant mosaicism, indicating exchange between the Neisseria and H. influenzae modA alleles. Regions of high inter- and intra-allele similarity indicate that some modA alleles had undergone recombination more frequently than others, generating further diversity. Furthermore, the DRD from some modA alleles, such as modA12, have been transferred en bloc to replace the DRD from different modA alleles

Wake up, wake up! It's me! It's my life! patient narratives on person-centeredness in the integrated care context: a qualitative study

Person-centered care emphasizes a holistic, humanistic approach that puts patients first, at the center of medical care. Person-centeredness is also considered a core element of integrated care. Yet typologies of integrated care mainly describe how patients fit within integrated services, rather than how services fit into the patient's world. Patient-centeredness has been commonly defined through physician's behaviors aimed at delivering patient-centered care. Yet, it is unclear how 'person-centeredness' is realized in integrated care through the patient voice. We aimed to explore patient narratives of person-centeredness in the integrated care context

Spontaneous and deliberate future thinking: A dual process account

© 2019 Springer Nature.This is the final published version of an article published in Psychological Research, licensed under a Creative Commons Attri-bution 4.0 International License. Available online at: https://doi.org/10.1007/s00426-019-01262-7.In this article, we address an apparent paradox in the literature on mental time travel and mind-wandering: How is it possible that future thinking is both constructive, yet often experienced as occurring spontaneously? We identify and describe two ‘routes’ whereby episodic future thoughts are brought to consciousness, with each of the ‘routes’ being associated with separable cognitive processes and functions. Voluntary future thinking relies on controlled, deliberate and slow cognitive processing. The other, termed involuntary or spontaneous future thinking, relies on automatic processes that allows ‘fully-fledged’ episodic future thoughts to freely come to mind, often triggered by internal or external cues. To unravel the paradox, we propose that the majority of spontaneous future thoughts are ‘pre-made’ (i.e., each spontaneous future thought is a re-iteration of a previously constructed future event), and therefore based on simple, well-understood, memory processes. We also propose that the pre-made hypothesis explains why spontaneous future thoughts occur rapidly, are similar to involuntary memories, and predominantly about upcoming tasks and goals. We also raise the possibility that spontaneous future thinking is the default mode of imagining the future. This dual process approach complements and extends standard theoretical approaches that emphasise constructive simulation, and outlines novel opportunities for researchers examining voluntary and spontaneous forms of future thinking.Peer reviewe

Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids

Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas between these allied fields of science. It is with this ethos that our group has taken an interest in and pursued the synthesis of a complex family of natural products termed the dimeric epipolythiodiketopiperazine (ETP) alkaloids. We present here an Account of the highly complex target molecules to which we pegged our ambitions, our systematic and relentless efforts toward those goals, the chemistry we developed in their pursuit, and the insight we have gained for their translational potential as potent anticancer molecules.National Institute of General Medical Sciences (U.S.) (Grant GM089732)Amgen Inc

Predictors of linkage to care following community-based HIV counseling and testing in rural Kenya

Despite innovations in HIV counseling and testing (HCT), important gaps remain in understanding linkage to care. We followed a cohort diagnosed with HIV through a community-based HCT campaign that trained persons living with HIV/AIDS (PLHA) as navigators. Individual, interpersonal, and institutional predictors of linkage were assessed using survival analysis of self-reported time to enrollment. Of 483 persons consenting to follow-up, 305 (63.2%) enrolled in HIV care within 3 months. Proportions linking to care were similar across sexes, barring a sub-sample of men aged 18–25 years who were highly unlikely to enroll. Men were more likely to enroll if they had disclosed to their spouse, and women if they had disclosed to family. Women who anticipated violence or relationship breakup were less likely to link to care. Enrolment rates were significantly higher among participants receiving a PLHA visit, suggesting that a navigator approach may improve linkage from community-based HCT campaigns.Vestergaard Frandse