150 research outputs found
A fast monolithic active pixel sensor with pixel level reset noise suppression and binary outputs for charged particle detection
In order to develop precision vertex detectors for the future linear collider, fast active monolithic active pixel sensors are studied. Standard CMOS 0.25 mum digital process is used to design a test chip which includes different pixel types, column-level discriminators and a digital control part. In-pixel amplification is implemented together with double sampling. Different charge-to-voltage conversion factors were obtained using amplifiers with different gains or diode sizes. Pixel architectures with DC and AC coupling to charge sensing element were proposed. As far, hits from conversion of 35Fe photons were registered for the DC-coupled pixel. Double sampling is functional and allows almost a complete cancellation if fixed pattern noise
CMOS Monolithic Active Pixel Sensors (MAPS) for future vertex detectors
This paper reviews the development of CMOS Monolithic Active Pixel Sensors
(MAPS) for future vertex detectors. MAPS are developed in a standard CMOS
technology. In the imaging field, where the technology found its first
applications, they are also known as CMOS Image Sensors. The use of MAPS as a
detector for particle physics was first proposed at the end of 1999. Since
then, their good performance in terms of spatial resolution, efficiency,
radiation hardness have been demonstrated and work is now well under way to
deliver the first MAPS-based vertex detectors.Comment: Invited talk at International Symposium on the Development of
Detectors for Particle, AstroParticle and Synchrtron Radiation Experiments,
Stanford Ca (SNIC06) 4 pages, pdf, 2 TIFF figures, PSN000
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization
An example of structural transformation of human skin sensitizers into various non-sensitizers based on interpretation of QSAR models
Alarms about structural alerts
Integrative approach for safety assessment of new chemicals by combining structural alerts and QSAR models
A critical overview of computational approaches employed for COVID-19 drug discovery
COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought the most severe disruptions to societies and economies since the Great Depression. Massive experimental and computational research effort to understand and characterize the disease and rapidly develop diagnostics, vaccines, and drugs has emerged in response to this devastating pandemic and more than 130 000 COVID-19-related research papers have been published in peer-reviewed journals or deposited in preprint servers. Much of the research effort has focused on the discovery of novel drug candidates or repurposing of existing drugs against COVID-19, and many such projects have been either exclusively computational or computer-aided experimental studies. Herein, we provide an expert overview of the key computational methods and their applications for the discovery of COVID-19 small-molecule therapeutics that have been reported in the research literature. We further outline that, after the first year the COVID-19 pandemic, it appears that drug repurposing has not produced rapid and global solutions. However, several known drugs have been used in the clinic to cure COVID-19 patients, and a few repurposed drugs continue to be considered in clinical trials, along with several novel clinical candidates. We posit that truly impactful computational tools must deliver actionable, experimentally testable hypotheses enabling the discovery of novel drugs and drug combinations, and that open science and rapid sharing of research results are critical to accelerate the development of novel, much needed therapeutics for COVID-19
Background studies for the EDELWEISS dark matter experiment
The EDELWEISS-II collaboration has completed a direct search for WIMP dark
matter using cryogenic Ge detectors (400 g each) and 384 kgdays of
effective exposure. A cross-section of pb is excluded at
90% C.L. for a WIMP mass of 85 GeV. The next phase, EDELWEISS-III, aims to
probe spin-independent WIMP-nucleon cross-sections down to a few
pb. We present here the study of gamma and neutron background
coming from radioactive decays in the set-up and shielding materials. We have
carried out Monte Carlo simulations for the completed EDELWEISS-II setup with
GEANT4 and normalised the expected background rates to the measured
radioactivity levels (or their upper limits) of all materials and components.
The expected gamma-ray event rate in EDELWEISS-II at 20-200 keV agrees with the
observed rate of 82 events/kg/day within the uncertainties in the measured
concentrations. The calculated neutron rate from radioactivity of 1.0-3.1
events (90% C.L.) at 20-200 keV in the EDELWEISS-II data together with the
expected upper limit on the misidentified gamma-ray events (), surface
betas (), and muon-induced neutrons (), do not contradict 5
observed events in nuclear recoil band. We have then extended the simulation
framework to the EDELWEISS-III configuration with 800 g crystals, better
material purity and additional neutron shielding inside the cryostat. The
gamma-ray and neutron backgrounds in 24 kg fiducial mass of EDELWEISS-III have
been calculated as 14-44 events/kg/day and 0.7-1.4 events per year,
respectively. The results of the background studies performed in the present
work have helped to select better purity components and improve shielding in
EDELWEISS-III to further reduce the expected rate of background events in the
next phase of the experiment.Comment: 15 pages, 9 figures, to be published in Astroparticle Physic
Final results of the EDELWEISS-II WIMP search using a 4-kg array of cryogenic germanium detectors with interleaved electrodes
The EDELWEISS-II collaboration has completed a direct search for WIMP dark
matter with an array of ten 400-g cryogenic germanium detectors in operation at
the Laboratoire Souterrain de Modane. The combined use of thermal phonon
sensors and charge collection electrodes with an interleaved geometry enables
the efficient rejection of gamma-induced radioactivity as well as near-surface
interactions. A total effective exposure of 384 kg.d has been achieved, mostly
coming from fourteen months of continuous operation. Five nuclear recoil
candidates are observed above 20 keV, while the estimated background is 3.0
events. The result is interpreted in terms of limits on the cross-section of
spin-independent interactions of WIMPs and nucleons. A cross-section of
4.4x10^-8 pb is excluded at 90%CL for a WIMP mass of 85 GeV. New constraints
are also set on models where the WIMP-nucleon scattering is inelastic.Comment: 23 pages, 5 figures; matches published versio
A search for low-mass WIMPs with EDELWEISS-II heat-and-ionization detectors
We report on a search for low-energy (E < 20 keV) WIMP-induced nuclear
recoils using data collected in 2009 - 2010 by EDELWEISS from four germanium
detectors equipped with thermal sensors and an electrode design (ID) which
allows to efficiently reject several sources of background. The data indicate
no evidence for an exponential distribution of low-energy nuclear recoils that
could be attributed to WIMP elastic scattering after an exposure of 113 kg.d.
For WIMPs of mass 10 GeV, the observation of one event in the WIMP search
region results in a 90% CL limit of 1.0x10^-5 pb on the spin-independent
WIMP-nucleon scattering cross-section, which constrains the parameter space
associated with the findings reported by the CoGeNT, DAMA and CRESST
experiments.Comment: PRD rapid communication accepte
Axion searches with the EDELWEISS-II experiment
We present new constraints on the couplings of axions and more generic
axion-like particles using data from the EDELWEISS-II experiment. The EDELWEISS
experiment, located at the Underground Laboratory of Modane, primarily aims at
the direct detection of WIMPs using germanium bolometers. It is also sensitive
to the low-energy electron recoils that would be induced by solar or dark
matter axions. Using a total exposure of up to 448 kg.d, we searched for
axion-induced electron recoils down to 2.5 keV within four scenarios involving
different hypotheses on the origin and couplings of axions. We set a 95% CL
limit on the coupling to photons GeV in
a mass range not fully covered by axion helioscopes. We also constrain the
coupling to electrons, , similar to the more
indirect solar neutrino bound. Finally we place a limit on , where is the
effective axion-nucleon coupling for Fe. Combining these results we
fully exclude the mass range keV for DFSZ axions and
keV for KSVZ axions
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