Water-resource records of Brevard County, Florida

The U. S. Geological Survey made a comprehensive investigation of the water resources of Brevard County from 1954 to 1958. The purposes of this investigation were: (1) to determine the occurrence and chemical quality of water in the streams and lakes, (2) to determine the location and the thickness of aquifers, and (3) to determine the occurrence and chemical quality of the ground water. During the period from 1933 to 1954, water records were collected from a few stream-gaging stations and a few observation wells. The purpose of this report is to present basic data collected during these investigations. (Document has 188 pages.

Clustering Phase Transitions and Hysteresis: Pitfalls in Constructing Network Ensembles

Ensembles of networks are used as null models in many applications. However, simple null models often show much less clustering than their real-world counterparts. In this paper, we study a model where clustering is enhanced by means of a fugacity term as in the Strauss (or "triangle") model, but where the degree sequence is strictly preserved -- thus maintaining the quenched heterogeneity of nodes found in the original degree sequence. Similar models had been proposed previously in [R. Milo et al., Science 298, 824 (2002)]. We find that our model exhibits phase transitions as the fugacity is changed. For regular graphs (identical degrees for all nodes) with degree k > 2 we find a single first order transition. For all non-regular networks that we studied (including Erdos - Renyi and scale-free networks) we find multiple jumps resembling first order transitions, together with strong hysteresis. The latter transitions are driven by the sudden emergence of "cluster cores": groups of highly interconnected nodes with higher than average degrees. To study these cluster cores visually, we introduce q-clique adjacency plots. We find that these cluster cores constitute distinct communities which emerge spontaneously from the triangle generating process. Finally, we point out that cluster cores produce pitfalls when using the present (and similar) models as null models for strongly clustered networks, due to the very strong hysteresis which effectively leads to broken ergodicity on realistic time scales.Comment: 13 pages, 11 figure

Network growth models and genetic regulatory networks

We study a class of growth algorithms for directed graphs that are candidate models for the evolution of genetic regulatory networks. The algorithms involve partial duplication of nodes and their links, together with innovation of new links, allowing for the possibility that input and output links from a newly created node may have different probabilities of survival. We find some counterintuitive trends as parameters are varied, including the broadening of indegree distribution when the probability for retaining input links is decreased. We also find that both the scaling of transcription factors with genome size and the measured degree distributions for genes in yeast can be reproduced by the growth algorithm if and only if a special seed is used to initiate the process.Comment: 8 pages with 7 eps figures; uses revtex4. Added references, cleaner figure

Drugs for neglected diseases: a failure of the market and a public health failure?

Infectious diseases cause the suffering of hundreds of millions of people, especially in tropical and subtropical areas. Effective, affordable and easy-to-use medicines to fight these diseases are nearly absent. Although science and technology are sufficiently advanced to provide the necessary medicines, very few new drugs are being developed. However, drug discovery is not the major bottleneck. Today's R&D-based pharmaceutical industry is reluctant to invest in the development of drugs to treat the major diseases of the poor, because return on investment cannot be guaranteed. With national and international politics supporting a free market-based world order, financial opportunities rather than global health needs guide the direction of new drug development. Can we accept that the dearth of effective drugs for diseases that mainly affect the poor is simply the sad but inevitable consequence of a global market economy? Or is it a massive public health failure, and a failure to direct economic development for the benefit of society? An urgent reorientation of priorities in drug development and health policy is needed. The pharmaceutical industry must contribute to this effort, but national and international policies need to direct the global economy to address the true health needs of society. This requires political will, a strong commitment to prioritize health considerations over economic interests, and the enforcement of regulations and other mechanisms to stimulate essential drug development. New and creative strategies involving both the public and the private sector are needed to ensure that affordable medicines for today's neglected diseases are developed. Priority action areas include advocating an essential medicines R&D agenda, capacity-building in and technology transfer to developing countries, elaborating an adapted legal and regulatory framework, prioritizing funding for essential drug development and securing availability, accessibility, distribution and rational use of these drugs

Cygnus X-3 in outburst : quenched radio emission, radiation losses and variable local opacity

We present multiwavelength observations of Cygnus X-3 during an extended outburst in 1994 February - March. Intensive radio monitoring at 13.3, 3.6 & 2.0 cm is complemented by observations at (sub)millimetre and infrared wavelengths, which find Cyg X-3 to be unusually bright and variable, and include the first reported detection of the source at 0.45 mm. We report the first confirmation of quenched radio emission prior to radio flaring independent of observations at Green Bank. The observations reveal evidence for wavelength-dependent radiation losses and gradually decreasing opacity in the environment of the radio jet. We find that the radiation losses are likely to be predominantly inverse Compton losses experienced by the radio-emitting electrons in the strong radiation field of a luminous companion to the compact object. We interpret the decreasing opacity during the flare sequence as resulting from a decreasing proportion of thermal electrons entrained in the jet, reflecting a decreasing density in the region of jet formation. We present, drawing in part on the work of other authors, a model based upon mass-transfer rate instability predicting gamma-ray, X-ray, infrared and radio trends during a radio flaring sequence.Comment: LaTeX, 11 pages, 6 figures. Submitted to MNRA

The physical gravitational degrees of freedom

When constructing general relativity (GR), Einstein required 4D general covariance. In contrast, we derive GR (in the compact, without boundary case) as a theory of evolving 3-dimensional conformal Riemannian geometries obtained by imposing two general principles: 1) time is derived from change; 2) motion and size are relative. We write down an explicit action based on them. We obtain not only GR in the CMC gauge, in its Hamiltonian 3 + 1 reformulation but also all the equations used in York's conformal technique for solving the initial-value problem. This shows that the independent gravitational degrees of freedom obtained by York do not arise from a gauge fixing but from hitherto unrecognized fundamental symmetry principles. They can therefore be identified as the long-sought Hamiltonian physical gravitational degrees of freedom.Comment: Replaced with published version (minor changes and added references

The Adsorption and Collapse Transitions in a Linear Polymer Chain near an Attractive Wall

We deduce the qualitative phase diagram of a long flexible neutral polymer chain immersed in a poor solvent near an attracting surface using phenomenological arguments. The actual positions of the phase boundaries are estimated numerically from series expansion up to 19 sites of a self-attracting self avoiding walk in three dimensions. In two dimensions, we calculate analytically phase boundaries in some cases for a partially directed model. Both the numerical as well as analytical results corroborate the proposed qualitative phase diagram.Comment: 8 pages, 8 figures, revte

Oncologic Emergencies

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.It has been estimated that genitourinary malignancies will account for 25% of new cancer diagnoses in the United States in 2005 (Jemal et al. 2005). While the incidence of many of these malignancies has increased over the past two decades, the mortality rates appear to be decreasing. Early cancer detection combined with improvements in surgical and nonsurgical oncologic therapy account for these trends. Although not common, newly diagnosed cancer patients occasionally present in an emergent, life-threatening manner that warrants immediate medical or surgical intervention. As the prevalence of genitourinary malignancies continues to expand, additional patients can be expected to develop disease or treatment-related complications. This chapter will serve to review the diagnosis and management of oncologic emergencies as they pertain to the urologist

Interannual variability of the outflow of Weddell Sea bottom water

The Weddell Sea Bottom Water (WSBW) export from 1999 to 2019 displays distinct seasonal and interannual variability. From 2014 into 2017 a marked salinity decrease was recorded, with the lowest salinity, 34.615, attained in early 2016. The reduced salinity is derived from the V‐shaped trough formed by a double front along the shelf break of the Weddell Gyre's western boundary, which is filled with a blend of surface water and modified Weddell Deep Water. We estimate that when the V‐shaped apex attains a depth of greater than ~700m, the thermobaric effect promotes its descent into the WSBW. We propose that this occurred during anomalously strong cyclonic wind stress curl over the Weddell Gyre from 2014 into 2017, which increased the intensity of the gyre and its western boundary current, deepening the V‐shape trough. The WSBW salinity increased to its prior to 2014 values as the wind stress relaxed in 2018