Male access and success in higher education

The gendered landscape of higher education (hereafter HE) has changed significantly over the past two decades. As has long been the case, men are more likely to secure graduatelevel employment after their degree, although the advantage over women in this respect is now marginal. Men still form the majority of faculty and HE managers. Since the early 1990s, however, women are now more likely to start an undergraduate course than men, to successfully complete it and to achieve a ‘good degree’. Although the gender gap is less significant beyond undergraduate study, women are also more likely to undertake post-graduate courses. The speed and scale of the change in undergraduate participation patterns makes it a social phenomenon meriting further attention

A proteomic and genomic investigation into the role of lamin A in colorectal cancer cell motility

Lamins are type V intermediate filament proteins found at the nuclear envelope. Expression of lamin A in colorectal cancer (CRC) tumours is correlated with poor prognosis and expression of lamin A in CRC cell lines promotes greatly increased cell motility. The aim of this study was to identify proteins that promote cell motility in response to lamin A expression and to investigate lamin A regulated changes in gene/protein expression and cytoskeletal organisation that might underpin the increased cell motility. The effects of lamin A expression were studied using quantitative proteomic and genomic methods using cells from the colorectal cancer cell line SW480 which had been transfected with GFP-lamin A (SW480/lamA) or GFP as a control (SW480/cntl). A biochemical fractionation technique was optimised for the preparation of cytoskeletal fractions which were analysed by 2D DIGE (2D difference in-gel electrophoresis) to reveal accurate and reproducible changes in the representation of proteins within the cytoskeleton in SW480/lamA cells compared to controls. The majority of proteins identified were either components of the actin/intermediate filament cytoskeleton, protein chaperones or translation initiation/elongation factors. Interestingly, tissue transglutaminase 2, a protein which modifies elements of the cytoskeleton and is associated with cancer progression, was highly over-represented in the cytoskeleton fraction of SW480/lamA cells. Ingenuity Pathway Analysis was used to analyse genome-wide Affymetrix microarray analysis of SW480/cntl and SW480/lamA cell lines. A highly significant interaction network was identified which clustered together genes linked to cancer, cellular movement and cellular growth and proliferation. Epithelial markers such as CDH1 were down-regulated and mesenchymal markers such as FN1 were up-regulated in cells expressing GFP-lamin A, which suggested that lamin A over-expression may lead to an epithelial-mesenchymal transition (EMT). As A-type lamins are known to modulate downstream effects of TGFβ signalling, and TGFβ is an inducer of EMT, changes in genes involved in TGFβ signalling were investigated. Knockdown of lamin A using siRNA led to decreased expression of TGFBI and SNAI2 followed by reduced cell motility. The data suggest that expression of lamin A in CRC cells causes changes in the organisation of the actin cytoskeleton and in TGFβ signalling, potentially involving an epithelial to mesenchymal transition, leading to increased cell motility and an increased risk of death from cancer

The Cathedral of Junk: A Cultural Critique Through Yard Art

An anti-monument to conspicuous consumption, The Cathedral of Junk was begun as personal expression and has grown into social commentary on the excess of consumerist waste. This thesis examines the social critique inherent in the Austin, Texas yard art structure. To fully understand the implications of the artwork, chapters situate the Cathedral of Junk within its peer group of yard art, examine the significance and use of recycled materials within art, and show how the materials and makeup of the Cathedral of Junk reveals its maker’s critique of society’s obsession with consumerism

Part-song arrangements for junior high school voices

This item was digitized by the Internet Archive. Thesis (M.M.E.)--Boston UniversityThe scarcity of song material suited to the ranges and abilities of junior high school students is a very real handicap to successful teaching. The changing voice of the boy sets definite limitations on range, and the uncertainty of pitch in that voice restricts the difficulty of the arrangement. The girl's voice is not so similarly handicapped, thus allowing more freedom in writing for upper parts. Taken in the light of these restrictions, much of the existing material is not practical. Verses in unison, or for a single part, do not encourage part feeling and tend to make the chorus sections more difficult to achieve after having learned the melody. Bass and tenor parts with a wide range, frequent skips, or quick-moving figures are not practical. In developing and arranging this material, the author started with a three-part song as a transitional piece. The tenor, or low-alto part is put in the bass clef as a start toward reading from that clef. The first few songs keep both tenor and bass parts very simple with only the elementary skips for the bass part. Gradually chromatic tones and more difficult skips are introduced in the bass part. Chromatics are used sooner and more frequently in the tenor part. Then come rhythmic problems, and last of all, combinations of all these problems. Opinion will differ as to the order of difficulty of these songs, since the difficulty depends on variable factors, such as melodic line, rhythmic appeal, key changes and the abilities and interests of the class. Some songs sung with ease by one class may prove troublesome in another group. However, an approximation of the order of difficulty was attempted. Some of this material is from well-known songs which ought to be a part of every young person's repertoire. The others are for the most part folk songs of fifteen different nations or peoples. One is part of an organ composition adapted for chorus. Two are original compositions. Suitable lyrics involve considerable research. Some of the catchy little folk songs, while very singable and easily arranged, cannot be translated literally, or definitely are not in good taste. In such cases, other lyrics must be found and adapted, or new ones written. In at least eight instances adaptations of words were necessary, different texts had to be found for five, and new lyrics were written for two

A Reusable Interaction Management Module: Use case for Empathic Robotic Tutoring

We demonstrate the workings of a stochastic Interaction Management and showcase this working as part of a learning environment that includes a robotic tutor who interacts with students, helping them through a pedagogical task

Summer 1980

Principles of Turfgrass Weed Control III. Broadleaf Weeds (page 3) To Stop Leaks, First Find Them (6) Turgrass Research Field Day (9) Gypsy Moth (10) Try Ground Covers for Low-Maintenance (13) Pesticide News (18

The effectiveness of an acceptance and commitment therapy self-help intervention for chronic pain

Objective: To evaluate the effectiveness of an Acceptance Commitment Therapy based self-help book for people with chronic pain. Method: This was a randomized 2 group study design. Over a 6-week period, 6 participants read the self-help book and completed exercises from it with weekly telephone support whereas 8 others formed a wait-list control group. Subsequently, 5 of the wait-list participants completed the intervention. Participants completed preintervention and postintervention questionnaires for acceptance, values illness, quality of life, satisfaction with life, depression, anxiety, and pain. Initial outcome data were collected for 8 control participants and 6 intervention participants. Including the wait-list controls, a total of 11 participants completed preintervention and postintervention measures. Whilst completing the self-help intervention, each week participants' rated the content of the book according to reading level and usefulness, and their comprehension of the content was also assessed. Results: Compared with controls, participants who completed the book showed improved quality of life and decreased anxiety. When data from all the treatment participants were pooled, those who completed the intervention showed statistically significant improvements (with large effect sizes) for acceptance, quality of life, satisfaction with life, and values illness. Medium effect sizes were found for improvements in pain ratings. Conclusions: These findings support the hypothesis that using the self-help book, with minimal therapist contact adds value to the lives of people who experience chronic pain

Preservatio III

Cooperative Extension Work in Agriculture and Home Economics, University of Missouri, College of Agriculture and the United States Department of Agriculture cooperating."February, 1939."Title from cover

Diabetic ketoacidosis-associated stroke in children and youth

Diabetic ketoacidosis (DKA) is a state of severe insulin deficiency, either absolute or relative, resulting in hyperglycemia and ketonemia. Although possibly underappreciated, up to 10 of cases of intracerebral complications associated with an episode of DKA, and/or its treatment, in children and youth are due to hemorrhage or ischemic brain infarction. Systemic inflammation is present in DKA, with resultant vascular endothelial perturbation that may result in coagulopathy and increased hemorrhagic risk. Thrombotic risk during DKA is elevated by abnormalities in coagulation factors, platelet activation, blood volume and flow, and vascular reactivity. DKA-associated cerebral edema may also predispose to ischemic injury and hemorrhage, though cases of stroke without concomitant cerebral edema have been identified. We review the current literature regarding the pathogenesis of stroke during an episode of DKA in children and youth. Copyright © 2011 Jennifer Ruth Foster et al