Shuttle system ascent aerodynamic and plume heating

The shuttle program provided a challenge to the aerothermodynamicist due to the complexity of the flow field around the vehicle during ascent, since the configuration causes multiple shock interactions between the elements. Wind tunnel tests provided data for the prediction of the ascent design heating environment which involves both plume and aerodynamic heating phenomena. The approach for the heating methodology based on ground test firings and the use of the wind tunnel data to formulate the math models is discussed

Water-resource records of Brevard County, Florida

The U. S. Geological Survey made a comprehensive investigation of the water resources of Brevard County from 1954 to 1958. The purposes of this investigation were: (1) to determine the occurrence and chemical quality of water in the streams and lakes, (2) to determine the location and the thickness of aquifers, and (3) to determine the occurrence and chemical quality of the ground water. During the period from 1933 to 1954, water records were collected from a few stream-gaging stations and a few observation wells. The purpose of this report is to present basic data collected during these investigations. (Document has 188 pages.

Groundwater—Surface Water Interactions in a Mountain-to-Coast Watershed: Effects of Climate Change and Human Stressors

Watersheds located within a mountain to coast physiographic setting have been described as having a highly interconnected surface water and groundwater environment. The quantification of groundwater—surface water interactions at the watershed scale requires upscaling. This study uses MIKE SHE, a coupled numerical model, to explore the seasonally and spatially dynamic nature of these interactions in the Cowichan Watershed on Vancouver Island, British Columbia, Canada. The calibrated model simulates a transition of the Cowichan River from mostly gaining within the valley, to losing stream near the coast where groundwater extraction is focused. Losing and gaining sections correlate with geological substrate. Recharge across the watershed accounts for 17% of precipitation. Climate change is projected to lessen snowpack accumulation in the high alpine and alter timing of snowmelt, resulting in higher spring and winter river discharge and lower summer flows

Corner transfer matrix renormalization group method for two-dimensional self-avoiding walks and other O(n) models

We present an extension of the corner transfer matrix renormalisation group (CTMRG) method to O(n) invariant models, with particular interest in the self-avoiding walk class of models (O(n=0)). The method is illustrated using an interacting self-avoiding walk model. Based on the efficiency and versatility when compared to other available numerical methods, we present CTMRG as the method of choice for two-dimensional self-avoiding walk problems.Comment: 4 pages 7 figures Substantial rewrite of previous version to include calculations of critical points and exponents. Final version accepted for publication in PRE (Rapid Communications

Network growth models and genetic regulatory networks

We study a class of growth algorithms for directed graphs that are candidate models for the evolution of genetic regulatory networks. The algorithms involve partial duplication of nodes and their links, together with innovation of new links, allowing for the possibility that input and output links from a newly created node may have different probabilities of survival. We find some counterintuitive trends as parameters are varied, including the broadening of indegree distribution when the probability for retaining input links is decreased. We also find that both the scaling of transcription factors with genome size and the measured degree distributions for genes in yeast can be reproduced by the growth algorithm if and only if a special seed is used to initiate the process.Comment: 8 pages with 7 eps figures; uses revtex4. Added references, cleaner figure

Drugs for neglected diseases: a failure of the market and a public health failure?

Infectious diseases cause the suffering of hundreds of millions of people, especially in tropical and subtropical areas. Effective, affordable and easy-to-use medicines to fight these diseases are nearly absent. Although science and technology are sufficiently advanced to provide the necessary medicines, very few new drugs are being developed. However, drug discovery is not the major bottleneck. Today's R&D-based pharmaceutical industry is reluctant to invest in the development of drugs to treat the major diseases of the poor, because return on investment cannot be guaranteed. With national and international politics supporting a free market-based world order, financial opportunities rather than global health needs guide the direction of new drug development. Can we accept that the dearth of effective drugs for diseases that mainly affect the poor is simply the sad but inevitable consequence of a global market economy? Or is it a massive public health failure, and a failure to direct economic development for the benefit of society? An urgent reorientation of priorities in drug development and health policy is needed. The pharmaceutical industry must contribute to this effort, but national and international policies need to direct the global economy to address the true health needs of society. This requires political will, a strong commitment to prioritize health considerations over economic interests, and the enforcement of regulations and other mechanisms to stimulate essential drug development. New and creative strategies involving both the public and the private sector are needed to ensure that affordable medicines for today's neglected diseases are developed. Priority action areas include advocating an essential medicines R&D agenda, capacity-building in and technology transfer to developing countries, elaborating an adapted legal and regulatory framework, prioritizing funding for essential drug development and securing availability, accessibility, distribution and rational use of these drugs

Clustering Phase Transitions and Hysteresis: Pitfalls in Constructing Network Ensembles

Ensembles of networks are used as null models in many applications. However, simple null models often show much less clustering than their real-world counterparts. In this paper, we study a model where clustering is enhanced by means of a fugacity term as in the Strauss (or "triangle") model, but where the degree sequence is strictly preserved -- thus maintaining the quenched heterogeneity of nodes found in the original degree sequence. Similar models had been proposed previously in [R. Milo et al., Science 298, 824 (2002)]. We find that our model exhibits phase transitions as the fugacity is changed. For regular graphs (identical degrees for all nodes) with degree k > 2 we find a single first order transition. For all non-regular networks that we studied (including Erdos - Renyi and scale-free networks) we find multiple jumps resembling first order transitions, together with strong hysteresis. The latter transitions are driven by the sudden emergence of "cluster cores": groups of highly interconnected nodes with higher than average degrees. To study these cluster cores visually, we introduce q-clique adjacency plots. We find that these cluster cores constitute distinct communities which emerge spontaneously from the triangle generating process. Finally, we point out that cluster cores produce pitfalls when using the present (and similar) models as null models for strongly clustered networks, due to the very strong hysteresis which effectively leads to broken ergodicity on realistic time scales.Comment: 13 pages, 11 figure

The Adsorption and Collapse Transitions in a Linear Polymer Chain near an Attractive Wall

We deduce the qualitative phase diagram of a long flexible neutral polymer chain immersed in a poor solvent near an attracting surface using phenomenological arguments. The actual positions of the phase boundaries are estimated numerically from series expansion up to 19 sites of a self-attracting self avoiding walk in three dimensions. In two dimensions, we calculate analytically phase boundaries in some cases for a partially directed model. Both the numerical as well as analytical results corroborate the proposed qualitative phase diagram.Comment: 8 pages, 8 figures, revte

OGSA/Globus Evaluation for Data Intensive Applications

We present an architecture of Globus Toolkit 3 based testbed intended for evaluation of applicability of the Open Grid Service Architecture (OGSA) for Data Intensive Applications.Comment: To be published in the proceedings of the XIX International Symposium on Nuclear Electronics and Computing (NEC'2003), Bulgaria, Varna, 15-20 September, 200