Small Angle Polarization in High Energy P--P Scattering Through Nonperturbative Chiral Symmetry Breaking

We show that a large anomalous contribution due to nonperturbative instanton-like gluonic field configurations to the axial charge of the proton implies high-energy spin effects in $p-p$ elastic scattering. This is the same mechanism which is responsible for anomalous baryon number violation at high energy in the standard model. We compute the proton polarization due to these effects and we show that it is proportional to the center-of-mass scattering angle with a universal (energy-independent) slope of order unity.Comment: (13 pages, 2 figures

Fluid-solid interaction in the rate-dependent failure of brain tissue and biomimicking gels

Brain tissue is a heterogeneous material, constituted by a soft matrix filled with cerebrospinal fluid. The interactions between, and the complexity of each of these components are responsible for the non-linear rate-dependent behaviour that characterizes what is one of the most complex tissue in nature. Here, we investigate the influence of the cutting rate on the fracture properties of brain, through wire cutting experiments. We also present a model for the rate-dependent behaviour of fracture propagation in soft materials, which comprises the effects of fluid interaction through a poro-hyperelastic formulation. The method is developed in the framework of finite strain continuum mechanics, implemented in a commercial finite element code, and applied to the case of an edge-crack remotely loaded by a controlled displacement. Experimental and numerical results both show a toughening effect with increasing rates, which is linked to the energy dissipated by the fluid-solid interactions in the process zone ahead of the crack

Emerging bone marrow microenvironment‐driven mechanisms of drug resistance in acute myeloid leukemia: Tangle or chance?

Acute myeloid leukemia (AML) has been considered for a long time exclusively driven by critical mutations in hematopoietic stem cells. Recently, the contribution of further players, such as stromal and immune bone marrow (BM) microenvironment components, to AML onset and progression has been pointed out. In particular, mesenchymal stromal cells (MSCs) steadily remodel the leukemic niche, not only favoring leukemic cell growth and development but also tuning their responsiveness to treatments. The list of mechanisms driven by MSCs to promote a leukemia drug-resistant phenotype has progressively expanded. Moreover, the relative proportion and the activation status of immune cells in the BM leukemic microenvironment may vary by influencing their reactivity against leukemic cells. In that, the capacity of the stroma to re‐program immune cells, thus promoting and/or hampering therapeutic efficacy, is emerging as a crucial aspect in AML biology, adding an extra layer of complexity. Current treatments for AML have mainly focused on eradicating leukemia cells, with little consideration for the leukemia‐damaged BM niche. Increasing evidence on the contribution of stromal and immune cells in response to therapy underscores the need to hold the mutual interplay, which takes place in the BM. A careful dissection of these interactions will help provide novel applications for drugs already under experimentation and open a wide array of opportunities for new drug discovery

Progress on neural parton distributions

We give a status report on the determination of a set of parton distributions based on neural networks. In particular, we summarize the determination of the nonsinglet quark distribution up to NNLO, we compare it with results obtained using other approaches, and we discuss its use for a determination of $\alpha_s$.Comment: 4 pages, 2 figs, uses dis2007.cls, to appear in the DIS 2007 workshop proceeding

Recent progress on NNPDF for LHC

We present recent results of the NNPDF collaboration on a full DIS analysis of Parton Distribution Functions (PDFs). Our method is based on the idea of combining a Monte Carlo sampling of the probability measure in the space of PDFs with the use of neural networks as unbiased universal interpolating functions. The general structure of the project and the features of the fit are described and compared to those of the traditional approaches.Comment: 4 pages, 6 figures, contribution for the proceedings of the conference "Rencontres de Moriond, QCD and High Energy Interactions

The role of new technologies to prevent suicide in adolescence. a systematic review of the literature

Background and objectives: Suicide in adolescents represents a major public health concern. To date, a growing number of suicide preventive strategies based on the use of new technologies are emerging. We aimed to provide an overview of the present literature on the use of new technologies in adolescent suicide prevention. Materials and methods: An electronic search was run using the following keywords: Technology OR Technologies OR APP OR Application OR mobile application) AND (Adolescent OR youth OR puberty) AND (Suicid* OR Self-harm OR self-destruction). Inclusion criteria were: English language, published in a peer-reviewed journal, suicide prevention with the use of new technologies among adolescents. Results: Our search strategy yielded a total of 12 studies on the use of telemedicine, 7 on mobile applications, and 3 on language detection. We also found heterogeneity regarding the study design: 3 are randomized controlled trials (RCT), 13 are open-label single group trials, 2 are randomized studies, and 1 is a cross-sectional study. Telemedicine was the most adopted tool, especially web-based approaches. Mobile applications mostly focused on screening of depressive symptoms and suicidal ideation, and for clinical monitoring through the use of text messages. Although telepsychiatry and mobile applications can provide a fast and safe tool, supporting and preceding a face-to-face clinical assessment, only a few studies demonstrated efficacy in preventing suicide among adolescents through the use of these interventions. Some studies suggested algorithms able to recognize people at risk of suicide from the exploration of the language on social media posts. Conclusions: New technologies were found to be well accepted and tolerated supports for suicide prevention in adolescents. However, to date, few data support the use of such interventions in clinical practice and preventive strategies. Further studies are needed to test their efficacy in suicide prevention among adolescents and young adults

The impact of heavy quark mass effects in the NNPDF global analysis

We discuss the implementation of the FONLL general-mass scheme for heavy quarks in deep-inelastic scattering in the FastKernel framework, used in the NNPDF series of global PDF analysis. We present the general features of FONLL and benchmark the accuracy of its implementation in FastKernel comparing with the Les Houches heavy quark benchmark tables. We then show preliminary results of the NNPDF2.1 analysis, in which heavy quark mass effects are included following the FONLL-A GM scheme.Comment: 5 pages, 3 figures; to appear in the proceedings of DIS 2010, Firenz

Apparent stress-strain relationships in experimental equipment where magnetorheological fluids operate under compression mode

Abstract: This paper presents an experimental investigation of two different magnetorheological ( MR) fluids, namely, water-based and hydrocarbon-based MR fluids in compression mode under various applied currents. Finite element method magnetics was used to predict the magnetic field distribution inside the MR fluids generated by a coil. A test rig was constructed where the MR fluid was sandwiched between two flat surfaces. During the compression, the upper surface was moved towards the lower surface in a vertical direction. Stress-strain relationships were obtained for arrangements of equipment where each type of fluid was involved, using compression test equipment. The apparent compressive stress was found to be increased with the increase in magnetic field strength. In addition, the apparent compressive stress of the water-based MR fluid showed a response to the compressive strain of greater magnitude. However, during the compression process, the hydrocarbon-based MR fluid appeared to show a unique behaviour where an abrupt pressure drop was discovered in a region where the apparent compressive stress would be expected to increase steadily. The conclusion is drawn that the apparent compressive stress of MR fluids is influenced strongly by the nature of the carrier fluid and by the magnitude of the applied current