Parental substance misuse and child welfare: Outcomes for children two years after referral

This article is available open access through the publisher’s website through the link below. Copyright @ 2007 The Authors.This paper reports on placement and welfare outcomes for children allocated a social worker where there was a concern about parental misuse of drugs or alcohol. All files going for allocation for long term work in four London boroughs over on average one year were examined (290 families). Of the 290, 100 families with 186 children involved concerns about parental substance misuse. File studies were carried out at allocation and two years post-referral for these children. At follow-up only 46% of the children remained with their main carer, with 26% living in the wider family and 27% in the formal care system. Logistic regression found the factors associated with children remaining at home were parental heroin misuse, violence and one or more parents being a first generation immigrant; factors associated with children moving were the child being a baby identified as at risk of harm and particular combinations who misused and family structure. A rating of welfare outcome was made based on educational, emotional/behavioural and health development. At follow-up, 47% of children had no problems, 31% had continuing problems and 22% had problems in more areas than at allocation. Regression analysis found the factors associated with poor welfare outcome were children remaining at home, domestic violence, alcohol misuse and being a boy. The combination of a high proportion of children moving carer and poor outcomes for those at home suggests that attention needs to be paid to improving outcomes in this area.The Nuffield Foundatio

The averaged characteristic polynomial for the Gaussian and chiral Gaussian ensembles with a source

In classical random matrix theory the Gaussian and chiral Gaussian random matrix models with a source are realized as shifted mean Gaussian, and chiral Gaussian, random matrices with real $(\beta = 1)$, complex ($\beta = 2)$ and real quaternion $(\beta = 4$) elements. We use the Dyson Brownian motion model to give a meaning for general $\beta > 0$. In the Gaussian case a further construction valid for $\beta > 0$ is given, as the eigenvalue PDF of a recursively defined random matrix ensemble. In the case of real or complex elements, a combinatorial argument is used to compute the averaged characteristic polynomial. The resulting functional forms are shown to be a special cases of duality formulas due to Desrosiers. New derivations of the general case of Desrosiers' dualities are given. A soft edge scaling limit of the averaged characteristic polynomial is identified, and an explicit evaluation in terms of so-called incomplete Airy functions is obtained.Comment: 21 page

Autoimmunity, Autoinflammation, and Infection in Uveitis

Funding/Support: No funding or grant support. Financial Disclosures: John V. Forrester has received an honorarium for lecturing from Janssen (London, UK). Lucia Kuffova has undertaken consultancy work for Abbvie (London, UK). Andrew D. Dick has undertaken consultancy work for Abbvie (London, UK), Roche (London, UK), and Genentech (London, UK) and has received honoraria from Janssen (London, UK) and Abbvie (London, UK). The authors attest that they meet the current ICMJE criteria for authorship.Peer reviewedPublisher PD

Growth models, random matrices and Painleve transcendents

The Hammersley process relates to the statistical properties of the maximum length of all up/right paths connecting random points of a given density in the unit square from (0,0) to (1,1). This process can also be interpreted in terms of the height of the polynuclear growth model, or the length of the longest increasing subsequence in a random permutation. The cumulative distribution of the longest path length can be written in terms of an average over the unitary group. Versions of the Hammersley process in which the points are constrained to have certain symmetries of the square allow similar formulas. The derivation of these formulas is reviewed. Generalizing the original model to have point sources along two boundaries of the square, and appropriately scaling the parameters gives a model in the KPZ universality class. Following works of Baik and Rains, and Pr\"ahofer and Spohn, we review the calculation of the scaled cumulative distribution, in which a particular Painlev\'e II transcendent plays a prominent role.Comment: 27 pages, 5 figure

Change management within an enterprise-wide packaged software implementation

A research report submitted to the Faculty of Commerce University of the Witwatersrand, Johannesburg for the Degree of Masters of CommerceInvestments in information technology have in many cases failed to deliver the anticipated benefits. It is now accepted that real value can only be leveraged by linking IT implementation to organisational change and process redesign. The management of this change is inextricably linked to the overall success of the implementation. The focus of the research was on identifying what the key elements of successful change management were. Research into generic change management was used as a basis for determining these critical success factors. The applicability of these factors in the case of an enterprise wide package software implementation was then tested through a case study method. The research showed that the factors developed were applicable in managing technology driven change. In addition to the factors developed, additional factors were identified as being relevant in the case of packaged software implementations.Andrew Chakane 201

The effects of super-fruits including Montmorency tart cherries and pomegranate on the human body: A literature review

This literature review explores several published articles that report results related to health benefits of super-fruits including Montmorency tart cherries and pomegranate. Research suggests that Montmorency tart cherry supplementation may have the ability to relieve pain by decreasing inflammation, prevent gout flare ups by reducing uric acid levels in the bloodstream, relieve insomnia with natural exogenous melatonin, and lessen symptoms of muscle damage from physical exertion by decreasing oxidative stress. Studies have also shown that pomegranate supplementation may have the ability to help prevent obesity by helping to decrease body weight and fat production and improving insulin sensitivity as well as reducing the risk for heart disease by preventing low density lipoproteins from accumulating and causing atherosclerosis. Studies also claim that pomegranate can be beneficial in treating gastrointestinal ailments, cancer prevention, wound healing. The following literature review will delve deeper into the mechanisms by which Montmorency tart cherries and pomegranate affect the human body