402 research outputs found
Two models of the influenza A M2 channel domain: verification by comparison
Background: The influenza M2 protein is a simple membrane protein, containing a single transmembrane helix. It is representative of a very large family of single-transmembrane helix proteins. The functional protein is a tetramer, with the four transmembrane helices forming a proton-permeable channel across the bilayer. Two independently derived models of the M2 channel domain are compared, in order to assess the success of applying molecular modelling approaches to simple membrane proteins.Results: The Cα RSMD between the two models is 1.7 Ä. Both models are composed of a left-handed bundle of helices, with the helices tilted roughly 15° relative to the (presumed) bilayer normal. The two models have similar pore radius profiles, with a pore cavity lined by the Ser31 and Gly34 residues and a pore constriction formed by the ring of His37 residues.Conclusions:Independent studies of M2 have converged on the same structural model for the channel domain. This model is in agreement with solid state NMR data. In particular, both model and NMR data indicate that the M2 helices are tilted relative to the bilayer normal and form a left-handed bundle. Such convergence suggests that, at least for simple membrane proteins, restraints-directed modelling might yield plausible models worthy of further computational and experimental investigation
Probing the cosmic star formation using long Gamma-Ray Bursts: New constraints from the Spitzer Space Telescope
We report on IRAC-4.5mic, IRAC-8.0mic and MIPS-24mic deep observations of 16
Gamma-Ray Burst (GRBs) host galaxies performed with the Spitzer Space
Telescope, and we investigate in the thermal infrared the presence of evolved
stellar populations and dust-enshrouded star-forming activity associated with
these objects. Our sample is derived from GRBs that were identified with
sub-arcsec localization between 1997 and 2001, and only a very small fraction
(~20%) of the targeted sources is detected down to f_4.5mic ~3.5microJy and
f_24mic ~85microJy (3sigma). This likely argues against a population dominated
by massive and strongly-starbursting (i.e., SFR > ~100 Msol/yr) galaxies as it
has been recently suggested from submillimeter/radio and optical studies of
similarly-selected GRB hosts. Furthermore we find evidence that some GRBs do
not occur in the most infrared-luminous regions -- hence the most actively
star-forming environments -- of their host galaxies. Should the GRB hosts be
representative of all star-forming galaxies at high redshift, models of
infrared galaxy evolution indicate that > ~50% of GRB hosts should have f_24mic
> ~100microJy. Unless the identification of GRBs prior to 2001 was prone to
strong selection effects biasing our sample against dusty galaxies, we infer in
this context that the GRBs identified with the current techniques can not be
directly used as unbiased probes of the global and integrated star formation
history of the Universe.Comment: ApJ in press, 23 pages, 8 figures (scheduled for the ApJ 10 May 2006,
v642 2 issue). Full resolution available at
http://perceval.as.arizona.edu/~elefloch/Publis/ms_grb_spitzer.pd
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Improved method for implicit Monte Carlo
The Implicit Monte Carlo (IMC) method has been used for over 30 years to analyze radiative transfer problems, such as those encountered in stellar atmospheres or inertial confinement fusion. Reference [2] provided an exact error analysis of IMC for 0-D problems and demonstrated that IMC can exhibit substantial errors when timesteps are large. These temporal errors are inherent in the method and are in addition to spatial discretization errors and approximations that address nonlinearities (due to variation of physical constants). In Reference [3], IMC and four other methods were analyzed in detail and compared on both theoretical grounds and the accuracy of numerical tests. As discussed in, two alternative schemes for solving the radiative transfer equations, the Carter-Forest (C-F) method and the Ahrens-Larsen (A-L) method, do not exhibit the errors found in IMC; for 0-D, both of these methods are exact for all time, while for 3-D, A-L is exact for all time and C-F is exact within a timestep. These methods can yield substantially superior results to IMC
The Truncated Disk of CoKu Tau/4
We present a model of a dusty disk with an inner hole which accounts for the
Spitzer Space Telescope Infrared Spectrograph observations of the low-mass
pre-main sequence star CoKu Tau/4. We have modeled the mid-IR spectrum (between
8 and 25 mic) as arising from the inner wall of a disk. Our model disk has an
evacuated inner zone of radius ~ 10 AU, with a dusty inner ``wall'', of
half-height ~ 2 AU, that is illuminated at normal incidence by the central
star. The radiative equilibrium temperature decreases from the inner disk edge
outward through the optically-thick disk; this temperature gradient is
responsible for the emission of the silicate bands at 10 and 20 mic. The
observed spectrum is consistent with being produced by Fe-Mg amorphous glassy
olivine and/or pyroxene, with no evidence of a crystalline component. The
mid-infrared spectrum of CoKu Tau/4 is reminiscent of that of the much older
star TW Hya, where it has been suggested that the significant clearing of its
inner disk is due to planet formation. However, no inner disk remains in CoKu
Tau/4, consistent with the star being a weak-emission (non-accreting) T Tauri
star. The relative youth of CoKu Tau/4 (~ 1 Myr) may indicate much more rapid
planet formation than typically assumed.Comment: 32 pages, 9 figures, accepted in Ap
A Spitzer IRS Spectral Atlas of Luminous 8 micron Sources in the Large Magellanic Cloud
We present an atlas of Spitzer Space Telescope Infrared Spectrograph (IRS)
spectra of highly luminous, compact mid-infrared sources in the Large
Magellanic Cloud. Sources were selected on the basis of infrared colors and 8
micron (MSX) fluxes indicative of highly evolved, intermediate- to high-mass
stars with current or recent mass loss at large rates. We determine the
chemistry of the circumstellar envelope from the mid-IR continuum and spectral
features and classify the spectral types of the stars. In the sample of 60
sources, we find 21 Red Supergiants (RSGs), 16 C-rich Asymptotic Giant Branch
(AGB) stars, 11 HII regions, 4 likely O-rich AGB stars, 4 Galactic O-rich AGB
stars, 2 OH/IR stars, and 2 B[e] supergiants with peculiar IR spectra. We find
that the overwhelming majority of the sample AGB stars (with typical IR
luminosities ~1.0E4 L_sun) have C-rich envelopes, while the O-rich objects are
predominantly luminous RSGs with L_IR ~ 1.0E5 L_sun. We determine mean
bolometric corrections to the stellar K-band flux densities and find that for
carbon stars, the bolometric corrections depend on the infrared color, whereas
for RSGs, the bolometric correction is independent of IR color. Our results
reveal that objects previously classified as PNe on the basis of IR colors are
in fact compact HII regions with very red IRS spectra that include strong
atomic recombination lines and PAH emission features. We demonstrate that the
IRS spectral classes in our sample separate clearly in infrared color-color
diagrams that use combinations of 2MASS data and synthetic IRAC/MIPS fluxes
derived from the IRS spectra. On this basis, we suggest diagnostics to identify
and classify, with high confidence levels, IR-luminous evolved stars and HII
regions in nearby galaxies using Spitzer and near-infrared photometry.Comment: 46 pages, 9 figures; accepted for publication in AJ; abstract
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Planetary Candidates Observed by Kepler IV: Planet Sample From Q1-Q8 (22 Months)
We provide updates to the Kepler planet candidate sample based upon nearly
two years of high-precision photometry (i.e., Q1-Q8). From an initial list of
nearly 13,400 Threshold Crossing Events (TCEs), 480 new host stars are
identified from their flux time series as consistent with hosting transiting
planets. Potential transit signals are subjected to further analysis using the
pixel-level data, which allows background eclipsing binaries to be identified
through small image position shifts during transit. We also re-evaluate Kepler
Objects of Interest (KOI) 1-1609, which were identified early in the mission,
using substantially more data to test for background false positives and to
find additional multiple systems. Combining the new and previous KOI samples,
we provide updated parameters for 2,738 Kepler planet candidates distributed
across 2,017 host stars. From the combined Kepler planet candidates, 472 are
new from the Q1-Q8 data examined in this study. The new Kepler planet
candidates represent ~40% of the sample with Rp~1 Rearth and represent ~40% of
the low equilibrium temperature (Teq<300 K) sample. We review the known biases
in the current sample of Kepler planet candidates relevant to evaluating planet
population statistics with the current Kepler planet candidate sample.Comment: 12 pages, 8 figures, Accepted ApJ Supplemen
Evaluating the GeoSnap 13-m Cut-Off HgCdTe Detector for mid-IR ground-based astronomy
New mid-infrared HgCdTe (MCT) detector arrays developed in collaboration with
Teledyne Imaging Sensors (TIS) have paved the way for improved 10-m
sensors for space- and ground-based observatories. Building on the successful
development of longwave HAWAII-2RGs for space missions such as NEO Surveyor, we
characterize the first 13-m GeoSnap detector manufactured to overcome the
challenges of high background rates inherent in ground-based mid-IR astronomy.
This test device merges the longwave HgCdTe photosensitive material with
Teledyne's 2048x2048 GeoSnap-18 (18-m pixel) focal plane module, which is
equipped with a capacitive transimpedance amplifier (CTIA) readout circuit
paired with an onboard 14-bit analog-to-digital converter (ADC). The final
assembly yields a mid-IR detector with high QE, fast readout (>85 Hz), large
well depth (>1.2 million electrons), and linear readout.
Longwave GeoSnap arrays would ideally be deployed on existing ground-based
telescopes as well as the next generation of extremely large telescopes. While
employing advanced adaptive optics (AO) along with state-of-the-art diffraction
suppression techniques, instruments utilizing these detectors could attain
background- and diffraction-limited imaging at inner working angles <10
, providing improved contrast-limited performance compared to JWST
MIRI while operating at comparable wavelengths. We describe the performance
characteristics of the 13-m GeoSnap array operating between 38-45K,
including quantum efficiency, well depth, linearity, gain, dark current, and
frequency-dependent (1/f) noise profile.Comment: 17 pages, 17 figures. Accepted for publication in special addition of
Astronomische Nachrichten / Astronomical Notes as a contribution to SDW202
Detection of Potential Transit Signals in the First Three Quarters of Kepler Mission Data
We present the results of a search for potential transit signals in the first
three quarters of photometry data acquired by the Kepler Mission. The targets
of the search include 151,722 stars which were observed over the full interval
and an additional 19,132 stars which were observed for only 1 or 2 quarters.
From this set of targets we find a total of 5,392 detections which meet the
Kepler detection criteria: those criteria are periodicity of the signal, an
acceptable signal-to-noise ratio, and a composition test which rejects spurious
detections which contain non-physical combinations of events. The detected
signals are dominated by events with relatively low signal-to-noise ratio and
by events with relatively short periods. The distribution of estimated transit
depths appears to peak in the range between 40 and 100 parts per million, with
a few detections down to fewer than 10 parts per million. The detected signals
are compared to a set of known transit events in the Kepler field of view which
were derived by a different method using a longer data interval; the comparison
shows that the current search correctly identified 88.1% of the known events. A
tabulation of the detected transit signals, examples which illustrate the
analysis and detection process, a discussion of future plans and open,
potentially fruitful, areas of further research are included
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