21 research outputs found
Mitigation needs adaptation: Tropical forestry and climate change
International audienceThe relationship between tropical forests and global climate change has so far focused on mitigation, while much less emphasis has been placed on how management activities may help forest ecosystems adapt to this change. This paper discusses how tropical forestry practices can contribute to maintaining or enhancing the adaptive capacity of natural and planted forests to global climate change and considers challenges and opportunities for the integration of tropical forest management in broader climate change adaptation. In addition to the use of reduced impact logging to maintain ecosystem integrity, other approaches may be needed, such as fire prevention and management, as well as specific silvicultural options aimed at facilitating genetic adaptation. In the case of planted forests, the normally higher intensity of management (with respect to natural forest) offers additional opportunities for implementing adaptation measures, at both industrial and smallholder levels. Although the integration in forest management of measures aimed at enhancing adaptation to climate change may not involve substantial additional effort with respect to current practice, little action appears to have been taken to date. Tropical foresters and forest-dependent communities appear not to appreciate the risks posed by climate change and, for those who are aware of them, practical guidance on how to respond is largely non-existent. The extent to which forestry research and national policies will promote and adopt management practices in order to assist production forests adapt to climate change is currently uncertain. Mainstreaming adaptation into national development and planning programs may represent an initial step towards the incorporation of climate change considerations into tropical forestry
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Recent evidence indicates that Aβ can misfold and aggregate into seeds that
structurally corrupt native proteins, mimicking a prion-like process. Several
studies using FAD animal models have demonstrated that intracerebral
infusion of brain extracts from APP-transgenic mice or AD patients induce
Aβ deposition and cerebral amyloid angiopathy. To carry out most of these
Aβ-seeding studies, APP-transgenic animal have been used. Nevertheless, it
remains to be elucidated whether Aβ deposition can be induced by Aβ-seeds
in a sporadic AD model that does not overexpress APP and produces wild
type human Aβ.
We used an innovative model to better understand the amyloidogenic events
that occur in sporadic AD. This hAβ-KI model, expresses wild-type human
Aβ under the control of the endogenous mouse APP gene. Aβ-seeds from
AD patients (stage C) from the AD Research Center (UCI) were
administered into 7-8-month-old hAβ-KI and as positive controls 3xTg-AD
mice were employed.
We demonstrated that amyloid seeds can stimulate Aβ aggregations in
3xTg-AD and hAβ-KI models. We found that Aβ aggregates occur earlier
in the 3xTg-AD vs hAβ-KI and that a longer term of treatment is necessary
to accelerate diffusible Aβ pathology in the hAβ-KI mice. Thereferoe, this
hAβ-KI model represents an important step towards the development of
next-generation animal models that will provide better predictive outcomes
for human patients.
Grants support: UCI MIND Pilot project (DBV), Ministry of Science
PID2019-108911RA-100 (DBV), U54 AG054349 (FML), Institute of
Health Carlos III PI18/01557 (AG) co-financed by FEDER funds (European
Union), NIH/NIA Grant P50 AG16573 (UCI-ADRC).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech