26 research outputs found

    From Fluid Identities to Sectarian Labels: A Historical Investigation of Indonesia’s Shi‘i Communities

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    Since 2011 Indonesia has experienced a rise in intra-Muslim sectarian violence, with Shi‘a and Ahmadi communities becoming the target of radical Sunni groups. Taking as point of departure the attacks on Shi‘a Muslims and the rapid polarization of Sunni and Shi‘i identities, this article aims at deconstructing the “Shi‘a” category. Identifying examples of how since the early century of the Islamization devotion for the Prophet Muhammad and his progeny (herein referred to as ‘Alid piety) has been incorporated in the archipelago’s “Sunni” religious rituals, and contrasting them to programmatic forms of Shi’ism (adherence to Ja‘fari fiqh) which spread in the socio-political milieu of the 1970s-1990s. This article argues not only that historically there has been much devotional common ground between “Sunni” and “Shi‘a”, but also that in the last decade much polarization has occurred within the “Shi‘a” group between those who value local(ized) forms of ritual and knowledge, and those who seek models of orthopraxy and orthodoxy abroad.[Sejak tahun 2011, kekerasan bernuansa aliran dalam internal muslim di Indonesia mengalami peningkatan, dengan komunitas Syiah dan Ahmadiyah menjadi sasaran kekerasan dari kelompok-kelompok Sunni radikal. Berangkat dari kasus penyerangan terhadap kelompok Syiah dan cepatnya polarisasi identitas Sunni-Syiah, artikel ini berusaha mendekonstruksi kriteria “Syiah” di Indonesia. Beberapa contoh praktik keagamaan menunjukkan bahwa sejak awal proses Islamisasi di nusantara, pengagungan terhadap diri Nabi dan keturunannya (dalam hal ini adalah keluarga ‘Alī ibn Abī Ṭālib) telah menyatu dalam ritual-ritual keagamaan kelompok Sunni. Artikel ini menunjukkan bahwa tidak hanya secara historis terdapat banyak kesamaan antara “Sunni” dan “Syiah” di Indonesia, bahkan juga terjadi polarisasi pada beberapa dekade terakhir di tengah penganut Syiah antara kelompok yang memilih bentuk-bentuk ritual dan pengetahuan local dengan kelompok yang mencari rujukan ortodoksi dan ortopraksi dari luar.

    Circulating microRNA (miRNA) expression profiling in plasma of patients with gestational diabetes mellitus reveals upregulation of miRNA miR-330-3p

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    Gestational diabetes mellitus (GDM) is characterized by insulin resistance accompanied by low/absent beta-cell compensatory adaptation to the increased insulin demand. Although the molecular mechanisms and factors acting on beta-cell compensatory response during pregnancy have been partially elucidated and reported, those inducing an impaired beta-cell compensation and function, thus evolving in GDM, have yet to be fully addressed. MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs, which negatively modulate gene expression through their sequence-specific binding to 3'UTR of mRNA target. They have been described as potent modulators of cell survival and proliferation and, furthermore, as orchestrating molecules of beta-cell compensatory response and function in diabetes. Moreover, it has been reported that miRNAs can be actively secreted by cells and found in many biological fluids (e.g., serum/plasma), thus representing both optimal candidate disease biomarkers and mediators of tissues crosstalk(s). Here, we analyzed the expression profiles of circulating miRNAs in plasma samples obtained from n = 21 GDM patients and from n = 10 non-diabetic control pregnant women (24-33 weeks of gestation) using TaqMan array microfluidics cards followed by RT-real-time PCR single assay validation. The results highlighted the upregulation of miR-330-3p in plasma of GDM vs non-diabetics. Furthermore, the analysis of miR-330-3p expression levels revealed a bimodally distributed GDM patients group characterized by high or low circulating miR-330 expression and identified as GDM-miR-330highand GDM-miR-330low. Interestingly, GDM-miR-330highsubgroup retained lower levels of insulinemia, inversely correlated to miR-330-3p expression levels, and a significant higher rate of primary cesarean sections. Finally, miR-330-3p target genes analysis revealed major modulators of beta-cell proliferation and of insulin secretion, such as the experimentally validated genes E2F1 and CDC42 as well as AGT2R2, a gene involved in the differentiation of mature beta-cells. In conclusion, we demonstrated that plasma miR-330-3p could be of help in identifying GDM patients with potential worse gestational diabetes outcome; in GDM, miR-330-3p may directly be transferred from plasma to beta-cells thus modulating key target genes involved in proliferation, differentiation, and insulin secretion

    New advances in metabolic syndrome, from prevention to treatment. The role of diet and food

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    The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome’s definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS

    ‘NOT A RELIGIOUS STATE’ A study of three Indonesian religious leaders on the relation of state and religion

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    This article explores the concept of a ‘secular state’ offered by three Indonesian religious leaders: a Catholic priest, Nicolaus Driyarkara (1913–1967), and two Muslim intellectuals who were also state officials, Mukti Ali (1923–2004) and Munawir Sjadzali (1925–2004). All three, who represented the immediate generation after the revolution for Indonesian independence from the Dutch (1945), defended the legitimacy of a secular state for Indonesia based on the state ideology Pancasila (Five Principles of Indonesia). In doing so, they argued that a religious state, for example an Islamic state, is incompatible with a plural nation that has diverse cultures, faiths, and ethnicities. The three also argued that the state should remain neutral about its citizens’ faith and should not be dominated by a single religion, i.e. Islam. Instead, the state is obliged to protect all religions embraced by Indonesians. This argument becomes a vital foundation in the establishment of Indonesia’s trajectory of unique ‘secularisation’. Whilst these three intellectuals opposed the idea of establishing a religious or Islamic state in Indonesia, it was not because they envisioned the decline of the role of religion in politics and the public domain but rather that they regarded religiosity in Indonesia as vital in nation building within a multi-religious society. In particular, the two Muslim leaders used religious legitimacy to sustain the New Order’s political stability, and harnessed state authority to modernise the Indonesian Islamic community

    Violence, Sectarianism, and the Politics of Religion: Articulations of Anti-Shi'a Discourses in Indonesia

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    Pan-Islam and Religious Nationalism: The Case of Kartosuwiryo and Negara Islam Indonesia

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    Page range: 125-146This paper investigates the (apparent) conflict between appeals to Pan-Islam transnationalism and religious nationalism in the Netherlands East Indies, between the 1920s and the 1950s. Analyzing the career and writings of S. M. Kartosuwiryo (1905-1962) —Sarekat Islam leader and founder of the Islamic State of Indonesia —the article argues that shifts from one ideological platform to the other functioned to rally support for the Islamic state project, in conjunction with historical contingencies

    Islam and the making of the nation: Kartosuwiryo and political Islam in twentieth-century Indonesia

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    For decades, scholars of Indonesia have rejected the religious claims of the Darul Islam movement, interpreting the antagonism between the Islamic state and Soekarno’s republic as a fight for power, self-assertion, or land rights. Recently Kartosuwiryo and the Darul Islam have become heroic symbols of the local Islamist struggle, offering an alternative vision of this politician. The author looks beyond this dichotomy between rebel and martyr to unveil a ‘third’ dimension of Kartosuwiryo—a politician whose legacy has been shaping the role of Islam in Indonesian politics for over fifty years. In a blend of archival sources, printed material, and oral accounts, the author follows the career and ideology of Kartosuwiryo, nationalist leader of the Sarekat Islam party and later Imam of the Islamic State of Indonesia. Following the trajectory of a political activism that was consistently dedicated to the formation of an independent Indonesian state, the chapters delineate the gradual radicalization of the Islamic party and of Kartosuwiryo’s own ideals from the 1920s until the 1950s. Focusing on the dialectic between the religious and secular anti-colonial movements, this book explores the failure of political Islam in the mid-1950s; the consolidation of the Pancasila state under Soekarno’s and Suharto’s regimes; the latter’s attempt to co-opt what was left of the Darul Islam in the 1970s; and the re-emergence of political Islam and Kartosuwiryo’s memory in the post-1998 era. A testament to the relevance of historical enquiry in understanding contemporary politics, Islam and the making of the nation guides the reader through the contingencies of the past that have led to the transformation of a nationalist leader into a ‘separatist rebel’ and a ‘martyr’, while at the same time shaping the public perception of political Islam and strengthening the position of the Pancasila in contemporary Indonesia. Chiara Formichi (1982) has a PhD from the Department of History of the School of Oriental and African Studies, University of London, in 2009, and she is Assistant Professor in Asian and International Studies at City University of Hong Kong. This monograph was drafted during a post-doctoral fellowship at the Asia Research Institute, National University of Singapore. Her interests include the political history of Indonesia, Islam in Southeast Asia, transnational Islamic movements, and inter-Asian intellectual flows. In addition to several articles, her publications include Beyond Shi’ism: Alid piety in Muslim Southeast Asia (London: I.B.Tauris, 2013), Formichi and Feener eds
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