764 research outputs found
Minactivin expression in human monocyte and macrophage populations
Adherent monolayer cultures of human blood monocytes, peritoneal macrophages, bone marrow macrophages, and colonic mucosa macrophages were examined for their ability to produce and secrete minactivin, a specific inactivator of urokinase-type plasminogen activator. All except colonic mucosa macrophages produced and secreted appreciable amounts of minactivin, but only blood monocytes were stimulated by muramyl dipeptide (adjuvant peptide) to increase production. The minactivin from each of these populations could be shown to preferentially inhibit urokinase-type plasminogen activator and not trypsin, plasmin, or 'tissue'-type plasminogen activator (HPA66). A plasminogen-activating enzyme present in monocyte cultures appeared unaffected by the presence of minactivin and could be shown to be regulated independently by dexamethasone
Models of spatiotemporal variation in rabbit abundance reveal management hot spots for an invasive species
First published: 25 January 2020The European rabbit (Oryctolagus cuniculus) is a notorious economic and environmental pest species in its invasive range. To better understand the population and range dynamics of this species, 41 years of abundance data have been collected from 116 unique sites across a broad range of climatic and environmental conditions in Australia. We analyzed this time series of abundance data to determine whether interâannual variation in climatic conditions can be used to map historic, contemporary, and potential future fluctuations in rabbit abundance from regional to continental scales. We constructed a hierarchical Bayesian regression model of relative abundance that corrected for observation error and seasonal biases. The corrected abundances were regressed against environmental and disease variables in order to project high spatiotemporal resolution, continentâwide rabbit abundances. We show that rabbit abundance in Australia is highly variable in space and time, being driven primarily by interâannual variation in temperature and precipitation in concert with the prevalence of a nonâpathogenic virus. Moreover, we show that interâannual variation in local spatial abundances can be mapped effectively at a continental scale using highly resolved spatiotemporal predictors, allowing âhotspotsâ of persistently high rabbit abundance to be identified. Importantly, crossâvalidated model performance was fair to excellent within and across distinct climate zones. Longâterm monitoring data for invasive species can be used to map fineâscale spatiotemporal fluctuations in abundance patterns when accurately accounting for inherent sampling biases. Our analysis provides ecologists and pest managers with a clearer understanding of the determinants of rabbit abundance in Australia, offering an important new approach for predicting spatial abundance patterns of invasive species at the nearâterm temporal scales that are directly relevant to resource management.Stuart C Brown, Konstans Wells, Emilie Roy-Dufresne, Susan Campbell, Brian Cooke, Tarnya Cox, Damien A. Fordha
Photometric Calibration of the Swift Ultraviolet/Optical Telescope
We present the photometric calibration of the Swift UltraViolet/Optical
Telescope (UVOT) which includes: optimum photometric and background apertures,
effective area curves, colour transformations, conversion factors for count
rates to flux, and the photometric zero points (which are accurate to better
than 4 per cent) for each of the seven UVOT broadband filters. The calibration
was performed with observations of standard stars and standard star fields that
represent a wide range of spectral star types. The calibration results include
the position dependent uniformity, and instrument response over the 1600-8000A
operational range. Because the UVOT is a photon counting instrument, we also
discuss the effect of coincidence loss on the calibration results. We provide
practical guidelines for using the calibration in UVOT data analysis. The
results presented here supersede previous calibration results.Comment: Minor improvements after referees report. Accepted for publication in
MNRA
The XMM-Newton Optical/UV Monitor Telescope
The XMM-OM instrument extends the spectral coverage of the XMM-Newton observatory into the ultraviolet and optical range. It provides imaging and time-resolved data on targets simultaneously with observations in the EPIC and RGS. It also has the ability to track stars in its field of view, thus providing an improved post-facto aspect solution for the spacecraft. An overview of the XMM-OM and its operation is given, together with current information on the performance of the instrument
The XMM-Newton Optical/UV Monitor Telescope
The XMM-OM instrument extends the spectral coverage of the XMM-Newton
observatory into the ultraviolet and optical range. It provides imaging and
time-resolved data on targets simultaneously with observations in the EPIC and
RGS. It also has the ability to track stars in its field of view, thus
providing an improved post-facto aspect solution for the spacecraft. An
overview of the XMM-OM and its operation is given, together with current
information on the performance of the instrument.Comment: Accepted by A&A for publication in the Special Issue on 1st science
with XMM Newton, 9 page
Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI : comparison of split vs single dose
Peer reviewe
Measurement of the diffractive structure function in deep inelastic scattering at HERA
This paper presents an analysis of the inclusive properties of diffractive
deep inelastic scattering events produced in interactions at HERA. The
events are characterised by a rapidity gap between the outgoing proton system
and the remaining hadronic system. Inclusive distributions are presented and
compared with Monte Carlo models for diffractive processes. The data are
consistent with models where the pomeron structure function has a hard and a
soft contribution. The diffractive structure function is measured as a function
of \xpom, the momentum fraction lost by the proton, of , the momentum
fraction of the struck quark with respect to \xpom, and of . The \xpom
dependence is consistent with the form \xpoma where
in all bins of and
. In the measured range, the diffractive structure function
approximately scales with at fixed . In an Ingelman-Schlein type
model, where commonly used pomeron flux factor normalisations are assumed, it
is found that the quarks within the pomeron do not saturate the momentum sum
rule.Comment: 36 pages, latex, 11 figures appended as uuencoded fil
Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML hematopoietic stem/progenitor cells (HSPCs), including an aberrant Lin-CD34+CD38-CD90+CD45RA+ population. Single-cell HSPC index-sorting and clonogenic assays show that (1) all somatic mutations can be backtracked to the phenotypic HSC compartment, with RAS-pathway mutations as a "first hit,"(2) mutations are acquired with both linear and branching patterns of clonal evolution, and (3) mutant HSPCs are present after allogeneic HSC transplant before molecular/clinical evidence of relapse. Stem cell assays reveal interpatient heterogeneity of JMML LSCs, which are present in, but not confined to, the phenotypic HSC compartment. RNA sequencing of JMML LSC reveals upregulation of stem cell and fetal genes (HLF, MEIS1, CNN3, VNN2, and HMGA2) and candidate therapeutic targets/biomarkers (MTOR, SLC2A1, and CD96), paving the way for LSC-directed disease monitoring and therapy in this disease
- âŠ