Use of mathematical derivatives (time-domain differentiation) on chromatographic data to enhance the detection and quantification of an unknown 'rider' peak

Two samples of an anticancer prodrug, AQ4N, were submitted for HPLC assay and showed an unidentified impurity that eluted as a 'rider' on the tail of the main peak. Mathematical derivatization of the chromatograms offered several advantages over conventional skimmed integration. A combination of the second derivative amplitude and simple linear regression gave a novel method for estimating the true peak area of the impurity peak. All the calculation steps were carried out using a widely available spreadsheet program. (C) 2003 Elsevier B.V. All rights reserved

Lightcone fluctuations in flat spacetimes with nontrivial topology

The quantum lightcone fluctuations in flat spacetimes with compactified spatial dimensions or with boundaries are examined. The discussion is based upon a model in which the source of the underlying metric fluctuations is taken to be quantized linear perturbations of the gravitational field. General expressions are derived, in the transverse trace-free gauge, for the summation of graviton polarization tensors, and for vacuum graviton two-point functions. Because of the fluctuating light cone, the flight time of photons between a source and a detector may be either longer or shorter than the light propagation time in the background classical spacetime. We calculate the mean deviations from the classical propagation time of photons due to the changes in the topology of the flat spacetime. These deviations are in general larger in the directions in which topology changes occur and are typically of the order of the Planck time, but they can get larger as the travel distance increases.Comment: 25 pages, 5 figures, some discussions added and a few typos corrected, final version to appear in Phys. Rev.

Restrictions on Negative Energy Density in Flat Spacetime

In a previous paper, a bound on the negative energy density seen by an arbitrary inertial observer was derived for the free massless, quantized scalar field in four-dimensional Minkowski spacetime. This constraint has the form of an uncertainty principle-type limitation on the magnitude and duration of the negative energy density. That result was obtained after a somewhat complicated analysis. The goal of the current paper is to present a much simpler method for obtaining such constraints. Similar ``quantum inequality'' bounds on negative energy density are derived for the electromagnetic field, and for the massive scalar field in both two and four-dimensional Minkowski spacetime.Comment: 17 pages, including two figures, uses epsf, minor revisions in the Introduction, conclusions unchange

The Effects of Stress Tensor Fluctuations upon Focusing

We treat the gravitational effects of quantum stress tensor fluctuations. An operational approach is adopted in which these fluctuations produce fluctuations in the focusing of a bundle of geodesics. This can be calculated explicitly using the Raychaudhuri equation as a Langevin equation. The physical manifestation of these fluctuations are angular blurring and luminosity fluctuations of the images of distant sources. We give explicit results for the case of a scalar field on a flat background in a thermal state.Comment: 26 pages, 1 figure, new material added in Sect. III and in Appendices B and

The Good Life: Who\u27s Practicing Healthy Life-styles?

With the birth of scientific medicine in the late 1800s, the responsibility for \u27health\u27 was increasingly removed from the individual and replaced by a dependence upon medical intervention and required public health measures. Individual responsibility was viewed largely in terms of assuring accessibility for the individual (and his/her family) to the professional health delivery system. The need for health care, therefore, was seen as episodic necessity -- not as a continuing individual responsibility

Analysis of the wind tunnel test of a tilt rotor power force model

Two series of wind tunnel tests were made to determine performance, stability and control, and rotor wake interaction on the airframe, using a one-tenth scale powered force model of a tilt rotor aircraft. Testing covered hover (IGE/OCE), helicopter, conversion, and airplane flight configurations. Forces and moments were recorded for the model from predetermined trim attitudes. Control positions were adjusted to trim flight (one-g lift, pitching moment and drag zero) within the uncorrected test data balance accuracy. Pitch and yaw sweeps were made about the trim attitudes with the control held at the trimmed settings to determine the static stability characteristics. Tail on, tail off, rotors on, and rotors off configurations were testes to determine the rotor wake effects on the empennage. Results are presented and discussed

Quantum measurement and decoherence

Distribution functions defined in accord with the quantum theory of measurement are combined with results obtained from the quantum Langevin equation to discuss decoherence in quantum Brownian motion. Closed form expressions for wave packet spreading and the attenuation of coherence of a pair of wave packets are obtained. The results are exact within the context of linear passive dissipation. It is shown that, contrary to widely accepted current belief, decoherence can occur at high temperature in the absence of dissipation. Expressions for the decoherence time with and without dissipation are obtained that differ from those appearing in earlier discussions

Twilight for the energy conditions?

The tension, if not outright inconsistency, between quantum physics and general relativity is one of the great problems facing physics at the turn of the millennium. Most often, the problems arising in merging Einstein gravity and quantum physics are viewed as Planck scale issues (10^{19} GeV, 10^{-34} m, 10^{-45} s), and so safely beyond the reach of experiment. However, over the last few years it has become increasingly obvious that the difficulties are more widespread: There are already serious problems of deep and fundamental principle at the semi-classical level, and worse, certain classical systems (inspired by quantum physics, but in no sense quantum themselves) exhibit seriously pathological behaviour. One manifestation of these pathologies is in the so-called ``energy conditions'' of general relativity. Patching things up in the gravity sector opens gaping holes elsewhere; and some ``fixes'' are more radical than the problems they are supposed to cure.Comment: Honourable mention in the 2002 Gravity Research Foundation essay contest. 12 pages. Plain LaTeX 2

Gravitational vacuum polarization III: Energy conditions in the (1+1) Schwarzschild spacetime

Building on a pair of earlier papers, I investigate the various point-wise and averaged energy conditions for the quantum stress-energy tensor corresponding to a conformally-coupled massless scalar field in the in the (1+1)-dimensional Schwarzschild spacetime. Because the stress-energy tensors are analytically known, I can get exact results for the Hartle--Hawking, Boulware, and Unruh vacua. This exactly solvable model serves as a useful sanity check on my (3+1)-dimensional investigations wherein I had to resort to a mixture of analytic approximations and numerical techniques. Key results in (1+1) dimensions are: (1) NEC is satisfied outside the event horizon for the Hartle--Hawking vacuum, and violated for the Boulware and Unruh vacua. (2) DEC is violated everywhere in the spacetime (for any quantum state, not just the standard vacuum states).Comment: 7 pages, ReV_Te

Cosmological and Black Hole Horizon Fluctuations

The quantum fluctuations of horizons in Robertson-Walker universes and in the Schwarzschild spacetime are discussed. The source of the metric fluctuations is taken to be quantum linear perturbations of the gravitational field. Lightcone fluctuations arise when the retarded Green's function for a massless field is averaged over these metric fluctuations. This averaging replaces the delta-function on the classical lightcone with a Gaussian function, the width of which is a measure of the scale of the lightcone fluctuations. Horizon fluctuations are taken to be measured in the frame of a geodesic observer falling through the horizon. In the case of an expanding universe, this is a comoving observer either entering or leaving the horizon of another observer. In the black hole case, we take this observer to be one who falls freely from rest at infinity. We find that cosmological horizon fluctuations are typically characterized by the Planck length. However, black hole horizon fluctuations in this model are much smaller than Planck dimensions for black holes whose mass exceeds the Planck mass. Furthermore, we find black hole horizon fluctuations which are sufficiently small as not to invalidate the semiclassical derivation of the Hawking process.Comment: 22 pages, Latex, 4 figures, uses eps