Do Aid Agencies Have an Ethical Duty to Comply with Researchers? A Response to Rennie.

Medical AID organisations such as Médecins Sans Frontières receive several requests from individuals and international academic institutions to conduct research at their implementation sites in Africa. Do AID agencies have an ethical duty to comply with research requests? In this paper we respond to the views and constructed theories (albeit unfounded) of one such researcher, whose request to conduct research at one of our sites in the Democratic Republic of Congo was turned down

Neutrinoless Double Beta Decay with SNO+

SNO+ will search for neutrinoless double beta decay by loading 780 tonnes of linear alkylbenzene liquid scintillator with O(tonne) of neodymium. Using natural Nd at 0.1% loading will provide 43.7 kg of 150Nd given its 5.6% abundance and allow the experiment to reach a sensitivity to the effective neutrino mass of 100-200 meV at 90% C.L in a 3 year run. The SNO+ detector has ultra low backgrounds with 7000 tonnes of water shielding and self-shielding of the scintillator. Distillation and several other purification techniques will be used with the aim of achieving Borexino levels of backgrounds. The experiment is fully funded and data taking with light-water will commence in 2012 with scintillator data following in 2013.Comment: 4 pages, 2 figures, prepared for TAUP 201

Exact solution of the Hu-Paz-Zhang master equation

The Hu-Paz-Zhang equation is a master equation for an oscillator coupled to a linear passive bath. It is exact within the assumption that the oscillator and bath are initially uncoupled . Here an exact general solution is obtained in the form of an expression for the Wigner function at time t in terms of the initial Wigner function. The result is applied to the motion of a Gaussian wave packet and to that of a pair of such wave packets. A serious divergence arising from the assumption of an initially uncoupled state is found to be due to the zero-point oscillations of the bath and not removed in a cutoff model. As a consequence, worthwhile results for the equation can only be obtained in the high temperature limit, where zero-point oscillations are neglected. In that limit closed form expressions for wave packet spreading and attenuation of coherence are obtained. These results agree within a numerical factor with those appearing in the literature, which apply for the case of a particle at zero temperature that is suddenly coupled to a bath at high temperature. On the other hand very different results are obtained for the physically consistent case in which the initial particle temperature is arranged to coincide with that of the bath

Does the Third Law of Thermodynamics hold in the Quantum Regime?

The first in a long series of papers by John T. Lewis, G. W. Ford and the present author, considered the problem of the most general coupling of a quantum particle to a linear passive heat bath, in the course of which they derived an exact formula for the free energy of an oscillator coupled to a heat bath in thermal equilibrium at temperature T. This formula, and its later extension to three dimensions to incorporate a magnetic field, has proved to be invaluable in analyzing problems in quantum thermodynamics. Here, we address the question raised in our title viz. Nernst's third law of thermodynamics

Development of shape memory metal as the actuator of a fail safe mechanism

A small, compact, lightweight device was developed using shape memory alloy (SMA) in wire form to actuate a pin-puller that decouples the flanges of two shafts. When the SMA is heated it contracts producing a useful force and stroke. As it cools, it can be reset (elongated in this case) by applying a relatively small force. Resistive heating is accomplished by running a current through the SMA wire for a controlled length of time. The electronics to drive the device are not elaborate or complicated, consisting of a timed current source. The total available contraction is 3 percent of the length of the wire. This device, the engineering properties of the SMA, and the tests performed to verify the design concept are described

Dynamics of Dinitrosyl Iron Complex (DNIC) Formation with Low Molecular Weight Thiols.

Dinitrosyl iron complexes (DNICs) are ubiquitous in mammalian cells and tissues producing nitric oxide (NO) and have been argued to play key physiological and pathological roles. Nonetheless, the mechanism and dynamics of DNIC formation in aqueous media remain only partially understood. Here, we report a stopped-flow kinetics and density functional theory (DFT) investigation of the reaction of NO with ferrous ions and the low molecular weight thiols glutathione (GSH) and cysteine (CysSH) as well as the peptides WCGPC and WCGPY to produce DNICs in pH 7.4 aqueous media. With each thiol, a two-stage reaction pattern is observed. The first stage involves several rapidly established pre-equilibria leading to a ferrous intermediate concluded to have the composition FeII(NO)(RS)2(H2O)x (C). In the second stage, C undergoes rate-limiting, unimolecular autoreduction to give thiyl radical (RS•) plus the mononitrosyl Fe(I) complex FeI(NO)(RS)(H2O)x following the reactivity order of CysSH > WCGPC > WCGPY > GSH. Time course simulations using the experimentally determined kinetics parameters demonstrate that, at a NO flux characteristic of inflammation, DNICs will be rapidly formed from intracellular levels of ferrous iron and thiols. Furthermore, the proposed mechanism offers a novel pathway for S-nitroso thiol (RSNO) formation in a biological environment

Gravitons and Lightcone Fluctuations II: Correlation Functions

A model of a fluctuating lightcone due to a bath of gravitons is further investigated. The flight times of photons between a source and a detector may be either longer or shorter than the light propagation time in the background classical spacetime, and will form a Gaussian distribution centered around the classical flight time. However, a pair of photons emitted in rapid succession will tend to have correlated flight times. We derive and discuss a correlation function which describes this effect. This enables us to understand more fully the operational significance of a fluctuating lightcone. Our results may be combined with observational data on pulsar timing to place some constraints on the quantum state of cosmological gravitons.Comment: 16 pages and two figures, uses eps

Brownian Motion in Robertson-Walker Space-Times from electromagnetic Vacuum Fluctuations

We consider classical particles coupled to the quantized electromagnetic field in the background of a spatially flat Robertson-Walker universe. We find that these particles typically undergo Brownian motion and acquire a non-zero mean squared velocity which depends upon the scale factor of the universe. This Brownian motion can be interpreted as due to non-cancellation of anti-correlated vacuum fluctuations in the time dependent background space-time. We consider several types of coupling to the electromagnetic field, including particles with net electric charge, a magnetic dipole moment, and electric polarizability. We also investigate several different model scale factors.Comment: 29 pages, 7 figure

Quantum measurement and decoherence

Distribution functions defined in accord with the quantum theory of measurement are combined with results obtained from the quantum Langevin equation to discuss decoherence in quantum Brownian motion. Closed form expressions for wave packet spreading and the attenuation of coherence of a pair of wave packets are obtained. The results are exact within the context of linear passive dissipation. It is shown that, contrary to widely accepted current belief, decoherence can occur at high temperature in the absence of dissipation. Expressions for the decoherence time with and without dissipation are obtained that differ from those appearing in earlier discussions

Quantum inequalities in two dimensional curved spacetimes

We generalize a result of Vollick constraining the possible behaviors of the renormalized expected stress-energy tensor of a free massless scalar field in two dimensional spacetimes that are globally conformal to Minkowski spacetime. Vollick derived a lower bound for the energy density measured by a static observer in a static spacetime, averaged with respect to the observers proper time by integrating against a smearing function. Here we extend the result to arbitrary curves in non-static spacetimes. The proof, like Vollick's proof, is based on conformal transformations and the use of our earlier optimal bound in flat Minkowski spacetime. The existence of such a quantum inequality was previously established by Fewster.Comment: revtex 4, 5 pages, no figures, submitted to Phys. Rev. D. Minor correction