29,041 research outputs found

    Lightcone fluctuations in flat spacetimes with nontrivial topology

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    The quantum lightcone fluctuations in flat spacetimes with compactified spatial dimensions or with boundaries are examined. The discussion is based upon a model in which the source of the underlying metric fluctuations is taken to be quantized linear perturbations of the gravitational field. General expressions are derived, in the transverse trace-free gauge, for the summation of graviton polarization tensors, and for vacuum graviton two-point functions. Because of the fluctuating light cone, the flight time of photons between a source and a detector may be either longer or shorter than the light propagation time in the background classical spacetime. We calculate the mean deviations from the classical propagation time of photons due to the changes in the topology of the flat spacetime. These deviations are in general larger in the directions in which topology changes occur and are typically of the order of the Planck time, but they can get larger as the travel distance increases.Comment: 25 pages, 5 figures, some discussions added and a few typos corrected, final version to appear in Phys. Rev.

    Resilience of Hierarchical Critical Infrastructure Networks

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    Concern over the resilience of critical infrastructure networks has increased dramatically over the last decade due to a number of well documented failures and the significant disruption associated with these. This has led to a large body of research that has adopted graph-theoretic based analysis in order to try and improve our understanding of infrastructure network resilience. Many studies have asserted that infrastructure networks possess a scale-free topology which is robust to random failures but sensitive to targeted attacks at highly connected hubs. However, many studies have ignored that many networks in addition to their topological connectivity may be organised either logically or spatially in a hierarchical system which may significantly change their response to perturbations. In this paper we explore if hierarchical network models exhibit significantly different higher-order topological characteristics compared to other network structures and how this impacts on their resilience to a number of different failure types. This is achieved by investigating a suite of synthetic networks as well as a suite of ‘real world’ spatial infrastructure networks

    Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response.

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    BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue. We used microarray analysis to determine which genes, pathways and networks were significantly altered using a rat model of TBI. Adult rats received a unilateral controlled cortical impact (CCI) and were sacrificed 24 h post-injury. The ipsilateral hemi-brain tissue at the site of the injury, the corresponding contralateral hemi-brain tissue, and naïve (control) brain tissue were used for microarray analysis. Ingenuity Pathway Analysis (IPA) software was used to identify molecular pathways and networks that were associated with the altered gene expression in brain tissues following TBI.ResultsInspection of the top fifteen biological functions in IPA associated with TBI in the ipsilateral tissues revealed that all had an inflammatory component. IPA analysis also indicated that inflammatory genes were altered on the contralateral side, but many of the genes were inversely expressed compared to the ipsilateral side. The contralateral gene expression pattern suggests a remote anti-inflammatory molecular response. We created a network of the inversely expressed common (i.e., same gene changed on both sides of the brain) inflammatory response (IR) genes and those IR genes included in pathways and networks identified by IPA that changed on only one side. We ranked the genes by the number of direct connections each had in the network, creating a gene interaction hierarchy (GIH). Two well characterized signaling pathways, toll-like receptor/NF-kappaB signaling and JAK/STAT signaling, were prominent in our GIH.ConclusionsBioinformatic analysis of microarray data following TBI identified key molecular pathways and networks associated with neural injury following TBI. The GIH created here provides a starting point for investigating therapeutic targets in a ranked order that is somewhat different than what has been presented previously. In addition to being a vehicle for identifying potential targets for post-TBI therapeutic strategies, our findings can also provide a context for evaluating the potential of therapeutic agents currently in development

    A quantum weak energy inequality for the Dirac field in two-dimensional flat spacetime

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    Fewster and Mistry have given an explicit, non-optimal quantum weak energy inequality that constrains the smeared energy density of Dirac fields in Minkowski spacetime. Here, their argument is adapted to the case of flat, two-dimensional spacetime. The non-optimal bound thereby obtained has the same order of magnitude, in the limit of zero mass, as the optimal bound of Vollick. In contrast with Vollick's bound, the bound presented here holds for all (non-negative) values of the field mass.Comment: Version published in Classical and Quantum Gravity. 7 pages, 1 figur

    Optimization of controlled environments for hydroponic production of leaf lettuce for human life support in CELSS

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    A research project in the food production group of the Closed Ecological Life Support System (CELSS) program sought to define optimum conditions for photosynthetic productivity of a higher plant food crop. The effects of radiation and various atmospheric compositions were studied

    Gravitons and Lightcone Fluctuations II: Correlation Functions

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    A model of a fluctuating lightcone due to a bath of gravitons is further investigated. The flight times of photons between a source and a detector may be either longer or shorter than the light propagation time in the background classical spacetime, and will form a Gaussian distribution centered around the classical flight time. However, a pair of photons emitted in rapid succession will tend to have correlated flight times. We derive and discuss a correlation function which describes this effect. This enables us to understand more fully the operational significance of a fluctuating lightcone. Our results may be combined with observational data on pulsar timing to place some constraints on the quantum state of cosmological gravitons.Comment: 16 pages and two figures, uses eps

    Bounds on negative energy densities in flat spacetime

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    We generalise results of Ford and Roman which place lower bounds -- known as quantum inequalities -- on the renormalised energy density of a quantum field averaged against a choice of sampling function. Ford and Roman derived their results for a specific non-compactly supported sampling function; here we use a different argument to obtain quantum inequalities for a class of smooth, even and non-negative sampling functions which are either compactly supported or decay rapidly at infinity. Our results hold in dd-dimensional Minkowski space (d≄2d\ge 2) for the free real scalar field of mass m≄0m\ge 0. We discuss various features of our bounds in 2 and 4 dimensions. In particular, for massless field theory in 2-dimensional Minkowski space, we show that our quantum inequality is weaker than Flanagan's optimal bound by a factor of 3/2.Comment: REVTeX, 13 pages and 2 figures. Minor typos corrected, one reference adde

    The history of mass assembly of faint red galaxies in 28 galaxy clusters since z=1.3

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    We measure the relative evolution of the number of bright and faint (as faint as 0.05 L*) red galaxies in a sample of 28 clusters, of which 16 are at 0.50<= z<=1.27, all observed through a pair of filters bracketing the 4000 Angstrom break rest-frame. The abundance of red galaxies, relative to bright ones, is constant over all the studied redshift range, 0<z<1.3, and rules out a differential evolution between bright and faint red galaxies as large as claimed in some past works. Faint red galaxies are largely assembled and in place at z=1.3 and their deficit does not depend on cluster mass, parametrized by velocity dispersion or X-ray luminosity. Our analysis, with respect to previous one, samples a wider redshift range, minimizes systematics and put a more attention to statistical issues, keeping at the same time a large number of clusters.Comment: MNRAS, 386, 1045. Half a single sentence (in sec 4.4) change

    Restrictions on Negative Energy Density in Flat Spacetime

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    In a previous paper, a bound on the negative energy density seen by an arbitrary inertial observer was derived for the free massless, quantized scalar field in four-dimensional Minkowski spacetime. This constraint has the form of an uncertainty principle-type limitation on the magnitude and duration of the negative energy density. That result was obtained after a somewhat complicated analysis. The goal of the current paper is to present a much simpler method for obtaining such constraints. Similar ``quantum inequality'' bounds on negative energy density are derived for the electromagnetic field, and for the massive scalar field in both two and four-dimensional Minkowski spacetime.Comment: 17 pages, including two figures, uses epsf, minor revisions in the Introduction, conclusions unchange
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