The batched stepped wedge design: A design robust to delays in cluster recruitment

Stepped wedge designs are an increasingly popular variant of longitudinal cluster randomized trial designs, and roll out interventions across clusters in a randomized, but step‐wise fashion. In the standard stepped wedge design, assumptions regarding the effect of time on outcomes may require that all clusters start and end trial participation at the same time. This would require ethics approvals and data collection procedures to be in place in all clusters before a stepped wedge trial can start in any cluster. Hence, although stepped wedge designs are useful for testing the impacts of many cluster‐based interventions on outcomes, there can be lengthy delays before a trial can commence. In this article, we introduce “batched” stepped wedge designs. Batched stepped wedge designs allow clusters to commence the study in batches, instead of all at once, allowing for staggered cluster recruitment. Like the stepped wedge, the batched stepped wedge rolls out the intervention to all clusters in a randomized and step‐wise fashion: a series of self‐contained stepped wedge designs. Provided that separate period effects are included for each batch, software for standard stepped wedge sample size calculations can be used. With this time parameterization, in many situations including when linear models are assumed, sample size calculations reduce to the setting of a single stepped wedge design with multiple clusters per sequence. In these situations, sample size calculations will not depend on the delays between the commencement of batches. Hence, the power of batched stepped wedge designs is robust to unexpected delays between batches

Pointing error compensation of electro-optical detection systems using Gaussian process regression

This work is supported by the National Key R&D Program of China (No.2017YFF0106401). The financial supports from the Natural Science Foundation of China (NSFC) under the grant 61701321 and that from the Natural Science Foundation of Shenzhen University (No. 860-000002110215) are also acknowledged

Sample size and power calculations for open cohort longitudinal cluster randomized trials.

When calculating sample size or power for stepped wedge or other types of longitudinal cluster randomized trials, it is critical that the planned sampling structure be accurately specified. One common assumption is that participants will provide measurements in each trial period, that is, a closed cohort, and another is that each participant provides only one measurement during the course of the trial. However some studies have an "open cohort" sampling structure, where participants may provide measurements in variable numbers of periods. To date, sample size calculations for longitudinal cluster randomized trials have not accommodated open cohorts. Feldman and McKinlay (1994) provided some guidance, stating that the participant-level autocorrelation could be varied to account for the degree of overlap in different periods of the study, but did not indicate precisely how to do so. We present sample size and power formulas that allow for open cohorts and discuss the impact of the degree of "openness" on sample size and power. We consider designs where the number of participants in each cluster will be maintained throughout the trial, but individual participants may provide differing numbers of measurements. Our results are a unification of closed cohort and repeated cross-sectional sample results of Hooper et al (2016), and indicate precisely how participant autocorrelation of Feldman and McKinlay should be varied to account for an open cohort sampling structure. We discuss different types of open cohort sampling schemes and how open cohort sampling structure impacts on power in the presence of decaying within-cluster correlations and autoregressive participant-level errors

Business cycles, international trade and capital flows: Evidence from Latin America

This paper adopts a flexible framework to assess both short- and long-run business cycle linkages between six Latin American (LA) countries and the four largest economies in the world (namely the US, the Euro area, Japan and China) over the period 1980:I-2011:IV. The result indicate that within the LA region there are considerable differences between countries, success stories coexisting with extremely vulnerable economies. They also show that the LA region as a whole is largely dependent on external developments, especially in the years after the great recession of 2008 and 2009. The trade channel appears to be the most important source of business cycle comovement, whilst capital flows are found to have a limited role, especially in the very short run

Be He@lthy - Be Mobile (A handbook on how to implement mAgeing)

The Be He@lthy, Be Mobile initiative is a global partnership led by the World Health Organization (WHO) and the International Telecommunication Union (ITU), representing the United Nations agencies for health and information and communications technologies (ICTs). The initiative supports the scale up of mobile health technology (mHealth) within national health systems to help combat noncommunicable diseases (NCDs) and support healthy ageing. Mobile health, or mHealth, is defined as "medical and public health practice supported by mobile devices, such as mobile phones, patient monitoring devices, personal digital assistants, and other wireless devices” (1). The Be Healthy, Be Mobile initiative uses basic technologies common in most mobile phones. The BHBM initiative has overseen the development and implementation of several mHealth programmes, including mTobaccoCessation (2), mDiabetes, and mCervicalCancer. The mHealth programme-specific handbooks act as aids to policy-makers and implementers of national or large-scale mHealth programs. See Annex 1 for further information on the Be He@lthy, Be Mobile initiative. mHealth for Ageing, or mAgeing is a new programme under the initiative, the central objective of which is to assist older persons (a person whose age has passed the median life expectancy at birth) in maintaining functional ability and living as independently and healthily as possible through evidence-based self-management and self-care interventions. This handbook provides guidance for national programmes and organizations responsible for the care of older persons to develop, implement, monitor, and evaluate an mAgeing programme. The text messaging communication provided uses evidence-based behaviour change techniques to help older persons prevent and manage early declines in intrinsic capacity and functional ability. The mAgeing programme is based on WHO’s Integrated Care for Older People (ICOPE): Guidelines on community-level interventions to manage declines in intrinsic capacity (3) which include interventions to prevent declines in intrinsic capacity and functional abilities in older people, namely: mobility loss, malnutrition, visual impairment and hearing loss; as well as cognitive impairments and depressive symptoms. The messages are designed to encourage participation in activities, and to prevent, reduce, or even partly reverse, significant losses in capacity. The content of the mAgeing programme will complement routine care offered by health care professionals by supporting self-care and self-management. All content in this handbook is based on the WHO ICOPE Guidelines and other relevant WHO recommendations. The ICOPE Guideline recommendations were reached by the consensus of a guideline development group, convened by WHO, which based its decisions on a summary of systematic reviews of the best quality evidence most relevant to community-level care for older people, as well as the most up-to-date research on the effectiveness of mHealth

The SLUGGS survey: the mass distribution in early-type galaxies within five effective radii and beyond

We study mass distributions within and beyond 5 effective radii (Re) in 23 early-type galaxies from the SAGES Legacy Unifying Globulars and Galaxies Survey, using their globular cluster (GC) kinematic data. The data are obtained with Keck/DEep Imaging Multi-Object Spectrograph, and consist of line-of-sight velocities for ̃3500 GCs, measured with a high precision of ̃15 km s-1 per GC and extending out to ̃13 Re. We obtain the mass distribution in each galaxy using the tracer mass estimator of Watkins et al. and account for kinematic substructures, rotation of the GC systems and galaxy flattening in our mass estimates. The observed scatter between our mass estimates and results from the literature is less than 0.2 dex. The dark matter fraction within 5 Re (fDM) increases from ̃0.6 to ̃0.8 for low- and high-mass galaxies, respectively, with some intermediate-mass galaxies (M* ̃ 1011 M☉) having low fDM ̃ 0.3, which appears at odds with predictions from simple galaxy models. We show that these results are independent of the adopted orbital anisotropy, stellar mass-to-light (M/L) ratio, and the assumed slope of the gravitational potential. However, the low fDM in the ̃1011 M☉ galaxies agrees with the cosmological simulations of Wu et al. where the pristine dark matter distribution has been modified by baryons during the galaxy assembly process. We find hints that these M* ̃ 1011 M☉ galaxies with low fDM have very diffuse dark matter haloes, implying that they assembled late. Beyond 5 Re, the M/L gradients are steeper in the more massive galaxies and shallower in both low and intermediate mass galaxies

Carbon savings in the UK demand side response programmes

We quantify carbon (CO2) savings in the demand side response (DSR) programmes. We consider Short Term Operating Reserve (STOR), Triad, Fast Reserve and Smart Meter roll-out, with various types of smart interventions involved (using diesel generators, hydro-pumped generation and use of tariffs). We model CO2 emissions in each of the DSR programmes with appropriate configurations and assumptions used in the energy industry. This enables us to compare carbon emissions between the business-as-usual (BAU) solutions and the smart intervention applied, thus deriving the carbon savings. Whether such DSR produces positive CO2 savings or not depends on the used technologies, as well as the scale of the interventions, which we illustrate in examples

Differences in genotype and virulence among four multidrug-resistant <i>Streptococcus pneumoniae</i> isolates belonging to the PMEN1 clone

We report on the comparative genomics and characterization of the virulence phenotypes of four &lt;i&gt;S. pneumoniae&lt;/i&gt; strains that belong to the multidrug resistant clone PMEN1 (Spain&lt;sup&gt;23F&lt;/sup&gt; ST81). Strains SV35-T23 and SV36-T3 were recovered in 1996 from the nasopharynx of patients at an AIDS hospice in New York. Strain SV36-T3 expressed capsule type 3 which is unusual for this clone and represents the product of an in vivo capsular switch event. A third PMEN1 isolate - PN4595-T23 - was recovered in 1996 from the nasopharynx of a child attending day care in Portugal, and a fourth strain - ATCC700669 - was originally isolated from a patient with pneumococcal disease in Spain in 1984. We compared the genomes among four PMEN1 strains and 47 previously sequenced pneumococcal isolates for gene possession differences and allelic variations within core genes. In contrast to the 47 strains - representing a variety of clonal types - the four PMEN1 strains grouped closely together, demonstrating high genomic conservation within this lineage relative to the rest of the species. In the four PMEN1 strains allelic and gene possession differences were clustered into 18 genomic regions including the capsule, the blp bacteriocins, erythromycin resistance, the MM1-2008 prophage and multiple cell wall anchored proteins. In spite of their genomic similarity, the high resolution chinchilla model was able to detect variations in virulence properties of the PMEN1 strains highlighting how small genic or allelic variation can lead to significant changes in pathogenicity and making this set of strains ideal for the identification of novel virulence determinant

Experimental testing of reciprocal effects of nutrition and parasitism in wild black capuchin monkeys

Nutritional stress may predispose individuals to infection, which in turn can have further detrimental effects on physical condition, thus creating an opportunity for reciprocal effects between nutrition and parasitism. Little experimental investigation has been conducted on this "vicious circle" hypothesis in wild animals, especially under natural conditions. We evaluated the reciprocal effects of nutritional status and parasitism using an experimental approach in two groups of wild black capuchin monkeys (Sapajus nigritus). Across two consecutive winters, we collected faecal samples from identified capuchins to determine presence and load of gastrointestinal helminthes, and measured individual body mass as a proxy of physical condition. Food availability was manipulated by provisioning monkeys with bananas, and parasite burdens by applying anti-parasitic drugs to selected individuals. We found no effect of anti-parasitic drugs on physical condition, but parasite loads decreased in response to high levels of food availability. Our results represent the first experimental evidence that the nutritional status may drive parasite dynamics in a primate.Fil: Agostini, Ilaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Vanderhoeven, Ezequiel Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Di Bitetti, Mario Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: Beldomenico, Pablo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Santa Fe. Instituto de Ciencias Veterinarias del Litoral; Argentina. Laboratorio de Ecología de Enfermedades; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentin