Generated heat by different targets irradiated by 660 MeV protons

246-254Calorimetric experiments have been performed to analyze different thick targets of natU, C, Pb material, irradiated by 660 MeV protons at the Phasotron accelerator facility, Joint Institute for Nuclear Research (JINR) in Dubna, Russia. The method of online temperature measurement has been compared with MCNPX 2.7.0 simulation and selected with Ansys Transient Thermal Simulation to compare measured temperature with the simulated one. Thermocouples type T and E have been used as a temperature probe. Many different positions have been measured for each target. Temperature results are following very well the processes inside of the cylinders. Changes of heat deposition caused by drops of the proton beam intensity are displayed very well as a jagged line shown in almost every chart. Accurate temperature changing measurement is a very modest variation of how to observe inner macroscopic behavior online

Generated heat by different targets irradiated by 660 MeV protons

Calorimetric experiments have been performed to analyze different thick targets of natU, C, Pb material, irradiated by 660 MeV protons at the Phasotron accelerator facility, Joint Institute for Nuclear Research (JINR) in Dubna, Russia. The method of online temperature measurement has been compared with MCNPX 2.7.0 simulation and selected with Ansys Transient Thermal Simulation to compare measured temperature with the simulated one. Thermocouples type T and E have been used as a temperature probe. Many different positions have been measured for each target. Temperature results are following very well the processes inside of the cylinders. Changes of heat deposition caused by drops of the proton beam intensity are displayed very well as a jagged line shown in almost every chart. Accurate temperature changing measurement is a very modest variation of how to observe inner macroscopic behavior online

Generated heat by different targets irradiated by 660 MeV protons

Calorimetric experiments have been performed to analyze different thick targets of natU, C, Pb material, irradiated by 660 MeV protons at the Phasotron accelerator facility, Joint Institute for Nuclear Research (JINR) in Dubna, Russia. The method of online temperature measurement has been compared with MCNPX 2.7.0 simulation and selected with Ansys Transient Thermal Simulation to compare measured temperature with the simulated one. Thermocouples type T and E have been used as a temperature probe. Many different positions have been measured for each target. Temperature results are following very well the processes inside of the cylinders. Changes of heat deposition caused by drops of the proton beam intensity are displayed very well as a jagged line shown in almost every chart. Accurate temperature changing measurement is a very modest variation of how to observe inner macroscopic behavior online

Faculty and Student Expectations and Perceptions of E-mail Communication in a Campus and Distance Doctor of Pharmacy Program

Objective. To examine faculty members’ and students’ expectations and perceptions of e-mail communication in a dual pathway pharmacy program. Methods. Three parallel survey instruments were administered to campus students, distance students, and faculty members, respectively. Focus groups with students and faculty were conducted. Results. Faculty members perceived themselves as more accessible and approachable by e-mail than either group of students did. Campus students expected a shorter faculty response time to e-mail and for faculty members to be more available than did distance students. Conclusion. E-mail is an effective means of computer-mediated communication between faculty members and students and can be used to promote a sense of community and inclusiveness (ie, immediacy), especially with distant students

Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.

Immunomodulatory (IMiD) agents like lenalidomide and pomalidomide induce the recruitment of IKZF1 and other targets to the CRL4CRBN E3 ubiquitin ligase, resulting in their ubiquitination and degradation. These agents are highly active in B-cell lymphomas and a subset of myeloid diseases but have compromised effects in T-cell lymphomas (TCLs). Here, we show that 2 factors determine resistance to IMiDs among TCLs. First, limited CRBN expression reduces IMiD activity in TCLs but can be overcome by newer-generation degrader CC-92480. Using mass spectrometry, we show that CC-92480 selectively degrades IKZF1 and ZFP91 in TCL cells with greater potency than pomalidomide. As a result, CC-92480 is highly active against multiple TCL subtypes and showed greater efficacy than pomalidomide across 4 in vivo TCL models. Second, we demonstrate that ZFP91 functions as a bona fide transcription factor that coregulates cell survival with IKZF1 in IMiD-resistant TCLs. By activating keynote genes from WNT, NF-kB, and MAP kinase signaling, ZFP91 directly promotes resistance to IKZF1 loss. Moreover, lenalidomide-sensitive TCLs can acquire stable resistance via ZFP91 rewiring, which involves casein kinase 2-mediated c-Jun inactivation. Overall, these findings identify a critical transcription factor network within TCLs and provide clinical proof of concept for the novel therapy using next-generation degraders

Building the future of public policy in the Basque Country: Etorkizuna Eraikiz, a metagovernance approach

From Crossref journal articles via Jisc Publications RouterHistory: ppub 2018-01-01, issued 2018-01-01, epub 2018-08-02Article version: Vo