The detection of ultra-faint low surface brightness dwarf galaxies in the Virgo Cluster: a Probe of Dark Matter and Baryonic Physics

We have discovered 11 ultra-faint ($r\lesssim 22.1$) low surface brightness (LSB, central surface brightness $23\lesssim \mu_r\lesssim 26$) dwarf galaxy candidates in one deep Virgo field of just $576$ arcmin$^2$ obtained by the Large Binocular Camera (LBC) at the Large Binocular Telescope (LBT). Their association with the Virgo cluster is supported by their distinct position in the central surface brightness - total magnitude plane with respect to the background galaxies of similar total magnitude. They have typical absolute magnitudes and scale sizes, if at the distance of Virgo, in the range $-13\lesssim M_r\lesssim -9$ and $250\lesssim r_s\lesssim 850$ pc, respectively. Their colors are consistent with a gradually declining star formation history with a specific star formation rate of the order of $10^{-11}$ yr$^{-1}$, i.e. 10 times lower than that of main sequence star forming galaxies. They are older than the cluster formation age and appear regular in morphology. They represent the faintest extremes of the population of low luminosity LSB dwarfs that has been recently detected in wider surveys of the Virgo cluster. Thanks to the depth of our observations we are able to extend the Virgo luminosity function down to $M_r\sim -9.3$ (corresponding to total masses $M\sim 10^7$ M$_{\odot}$), finding an average faint-end slope $\alpha\simeq -1.4$. This relatively steep slope puts interesting constraints on the nature of the Dark Matter and in particular on warm Dark Matter (WDM) often invoked to solve the overprediction of the dwarf number density by the standard CDM scenario. We derive a lower limit on the WDM particle mass $>1.5$ keV.Comment: accepted for publication in ApJ, 13 pages, 6 figure

The metal absorption systems of the Hubble Deep Field South QSO

The Hubble Deep Field South (HDFS) has been recently selected and the observations are planned for October 1998. We present a high resolution (FWHM $\simeq 14$ \kms) spectrum of the quasar J2233--606 ($z_{em}\simeq2.22$) which is located 5.1 arcmin East of the HDFS. The spectrum obtained with the New Technology Telescope redward of the Lyman--$\alpha$ emission line covers the spectral range 4386--8270 \AA. This range corresponds to redshift intervals for CIV and MgII intervening systems of $z=1.83-2.25$ and $z=0.57-1.95$ respectively. The data reveal the presence of two complex intervening CIV systems at redshift $z=1.869$ and $z=1.943$ and two complex associated ($z_{abs} \approx z_{em}$) systems. Other two CIV systems at $z=1.7865$ and $z=2.077$, suggested by the presence of strong Lyman--$\alpha$ lines in low resolution ground based and Hubble Space Telescope (HST) STIS observations (Sealey et al. 1998) have been identified. The system at $z=1.943$ is also responsible for the Lyman limit absorption seen in the HST/STIS spectrum. The main goal of the present work is to provide astronomers interested in the Hubble Deep Field South program with information related to absorbing structures at high redshift, which are distributed along the nearby QSO line of sight. For this purpose, the reduced spectrum, obtained from three hours of integration time, has been released to the astronomical community.Comment: revisited version accepted for publication by Astronomical Journal; minor changes; typographical errors corrected; results and discussion unchange

Thermodynamic Scaling of the Viscosity of Van Der Waals, H-Bonded, and Ionic Liquids

Viscosities and their temperature, T, and volume, V, dependences are reported for 7 molecular liquids and polymers. In combination with literature viscosity data for 5 other liquids, we show that the superpositioning of relaxation times for various glass-forming materials when expressed as a function of TV^g, where the exponent g is a material constant, can be extended to the viscosity. The latter is usually measured to higher temperatures than the corresponding relaxation times, demonstrating the validity of the thermodynamic scaling throughout the supercooled and higher T regimes. The value of g for a given liquid principally reflects the magnitude of the intermolecular forces (e.g., steepness of the repulsive potential); thus, we find decreasing g in going from van der Waals fluids to ionic liquids. For strongly H-bonded materials, such as low molecular weight polypropylene glycol and water, the superpositioning fails, due to the non-trivial change of chemical structure (degree of H-bonding) with thermodynamic conditions.Comment: 16 pages 7 figure

Comparing the Evolution of the Galaxy Disk Sizes with CDM Models: The Hubble Deep Field

The intrinsic sizes of the field galaxies with I<26 in the Hubble and ESO-NTT Deep Fields are shown as a function of their redshifts and absolute magnitudes using photometric redshifts derived from the multicolor catalogs and are compared with the CDM predictions. Extending to lower luminosities and to higher z our previous analysis performed on the NTT field alone, we find that the distribution of the galaxy disk sizes at different cosmic epochs is within the range predicted by typical CDM models. However, the observed size distribution of faint (M_B>-19) galaxies is skewed with respect to the CDM predictions and an excess of small-size disks (R_d<2 kpc) is already present at z~ 0.5. The excess persists up to z~3 and involves brighter galaxies . Such an excess may be reduced if luminosity-dependent effects, like starburst activity in interacting galaxies, are included in the physical mechanisms governing the star formation history in CDM models.Comment: 9 pages, 3 figures, ApJ Letters in pres

Galaxy Counts, Sizes, Colours and Redshifts in the Hubble Deep Field

We compare the galaxy evolution models of Bruzual & Charlot (1993) with the faint galaxy count, size and colour data from the Hubble and Herschel Deep Fields (Metcalfe et al 1996). For qo=0.05, we find that models where the SFR increases exponentially out to z>2 are consistent with all of the observational data. For qo=0.5, such models require an extra population of galaxies which are only seen at high redshift and then rapidly fade or disappear. We find that, whatever the cosmology, the redshift of the faint blue galaxies and hence the epoch of galaxy formation is likely to lie at z>2. We find no implied peak in the SFR at z=1 and we suggest that the reasons for this contradiction with the results of Madau et al (1996) include differences in faint galaxy photometry, in the treatment of spiral dust and in the local galaxy count normalisation.Comment: 8 pages, 5 eps figures, needs paspconf.st

Protein cargo of salivary small extracellular vesicles as potential functional signature of oral squamous cell carcinoma

The early diagnosis of oral squamous cell carcinoma (OSCC) is still an investigative challenge. Saliva has been proposed as an ideal diagnostic medium for biomarker detection by mean of liquid biopsy technique. The aim of this pilot study was to apply proteomic and bioinformatic strategies to determine the potential use of saliva small extracellular vesicles (S/SEVs) as a potential tumor biomarker source. Among the twenty-three enrolled patients, 5 were free from diseases (OSCC_FREE), 6 were with OSCC without lymph node metastasis (OSCC_NLNM), and 12 were with OSCC and lymph node metastasis (OSCC_LNM). The S/SEVs from patients of each group were pooled and properly characterized before performing their quantitative proteome comparison based on the SWATH_MS (Sequential Window Acquisition of all Theoretical Mass Spectra) method. The analysis resulted in quantitative information for 365 proteins differentially characterizing the S/SEVs of analyzed clinical conditions. Bioinformatic analysis of the proteomic data highlighted that each S/SEV group was associated with a specific cluster of enriched functional network terms. Our results highlighted that protein cargo of salivary small extracellular vesicles defines a functional signature, thus having potential value as novel predict biomarkers for OSCC

Phonon Properties of Knbo3 and Ktao3 from First-Principles Calculations

The frequencies of transverse-optical $\Gamma$ phonons in KNbO$_3$ and KTaO$_3$ are calculated in the frozen-phonon scheme making use of the full-potential linearized muffin-tin orbital method. The calculated frequencies in the cubic phase of KNbO$_3$ and in the tetragonal ferroelectric phase are in good agreement with experimental data. For KTaO$_3$, the effect of lattice volume was found to be substantial on the frequency of the soft mode, but rather small on the relative displacement patterns of atoms in all three modes of the $T_{1u}$ symmetry. The TO frequencies in KTaO$_3$ are found to be of the order of, but somehow higher than, the corresponding frequencies in cubic KNbO$_3$.Comment: 8 pages + 1 LaTeX figure, Revtex 3.0, SISSA-CM-94-00

Phyllotactic pattern and stem cell fate are determined by the Arabidopsis homeobox gene BELLRINGER

Lateral organs in plants arise from the meristem in a stereotypical pattern known as phyllotaxy. Spiral patterns result from initiation of successive organs at a fixed angle of divergence but variable patterns of physical contact. Such patterns ultimately give rise to individual leaves and flowers at positions related to each other by consecutive terms in the mathematical series first described by Leonardo Fibonacci. We demonstrate that a BELL1 related homeodomain protein in Arabidopsis, BELLRINGER, maintains the spiral phyllotactic pattern. In the absence of BELLRINGER, the regular pattern of organ initiation is disturbed and lateral organs are initiated more frequently. BELLRINGER is also required for maintenance of stem cell fate in the absence of the regulatory genes SHOOT MERISTEMLESS and ASYMMETRIC LEAVES1. We propose a model whereby BELLRINGER coordinates the maintenance of stem cells with differentiation of daughter cells in stem cell lineages