Hypoxia and HIF signaling: One axis with divergent effects

The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole organism. The cellular response to hypoxia is characterized by the activation of multiple genes involved in many biological processes. Among them, hypoxia-inducible factor (HIF) represents the master regulator of the hypoxia response. The active heterodimeric complex HIF α/β, binding to hypoxia-responsive elements (HREs), determines the induction of at least 100 target genes to restore tissue homeostasis. A growing body of evidence demonstrates that hypoxia signaling can act by generating contrasting responses in cells and tissues. Here, this dual and controversial role of hypoxia and the HIF signaling pathway is discussed, with particular reference to the effects induced on the complex activities of the immune system and on mechanisms determining cell and tissue responses after an injury in both acute and chronic human diseases related to the heart, lung, liver, and kidney

An exploratory study on internet addiction, somatic symptoms and emotional and behavioral functioning in school-aged adolescents

Objective: In the last two decades there has been a significant transformation regarding the use of new technologies. Despite growing acknowledgement concerning the different activities and functions of digital technologies, there remains a lack of understanding on how technology overuse may negatively impact both physical and psychosocial well-being. Although researchers have begun to explore the meaning and implications of excessive Internet use in non-clinical populations of children and adolescents, there is still little consistent knowledge on the topic. This study aimed to extend existing knowledge on the excessive use of the Internet among school-aged adolescents, focusing on its association with recurrent somatic symptoms, depressive risk and behavioral and emotional problems. Method: Two hundred and forty adolescents (51.9% females) aged between 10 and 15, participated in this study. Data was collected using the Children’s Somatization Inventory, the Internet Addiction Test, the Children’s Depression Inventory, the Youth Self Report and the Emotion Regulation Questionnaire. Structural Equation Model analysis was used to analyse the data. Results: Approximately 21.8% of participants reported excessive Internet use based on Young’s criteria. Higher levels of Internet use were associated with somatic and depressive symptoms as well as emotional and behavioral problems. Depressive Symptoms predicted both Internet Addiction (b = 0.304, p < 0.001) and Internalizing (b = 0.542, p <0.001) and Externalizing problems (b = 0.484, p < 0.001). Internet Addiction also significantly predicted both Internalizing (b = 0.162, p = 0.02) and Externalizing problems (b = 0.183, p = 0.02). Finally, Structural Equation Modeling showed that the indirect effect of Depressive Symptoms (via Internet Addiction) on Internalizing or Externalizing problems were significant. Conclusions: Longitudinal studies are needed to confirm these findings and to identify the mechanisms linking Internet use, somatic symptoms and adaptive functioning

¿Modifican el PSA los licopenos de la dieta y exógenos?

El objetivo del presente artículo es describir la historia alimentaria y la composición corporal de pacientes con alto riesgo de padecer cáncer de próstata (CAP) y observar la influencia de la suplementación con licopeno sobre el PSA de la misma población.Fil: López Laur, José Daniel. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: López Fontana, C.. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: López Fontana, G.. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: López Fontana, R.. Universidad Nacional de Cuyo. Facultad de Ciencias Médica

About Superluminal motions and Special Relativity: A Discussion of some recent Experiments, and the solution of the Causal Paradoxes

Some experiments, performed at Berkeley, Cologne, Florence, Vienna, Orsay, Rennes, etc., led to the claim that something seems to travel with a group velocity larger than the speed c of light in vacuum. Various other experimental results seem to point in the same direction: For instance, localized wavelet- type solutions to Maxwell equations have been found, both theoretically and experimentally, that travel with superluminal speed. [Even muonic and electronic neutrinos [it has been proposed] might be "tachyons", since their square mass appears to be negative]. With regard to the first-mentioned experiments, it was recently claimed by Guenter Nimtz that those results with evanescent waves (or tunneling photons) imply superluminal signal and impulse transmission, and therefore violate Einstein causality. In this note we want to stress that, on the contrary, all such results do not place relativistic causality in jeopardy, even if they referred to actual tachyonic motions: In fact, Special Relativity can cope even with superluminal objects and waves. For instance, it is possible (at least in microphysics) to solve also the known causal paradoxes, devised for faster than light motion, although this is not widely recognized yet. Here we show, in detail and rigorously, how to solve the oldest causal paradox, originally proposed by Tolman, which is the kernel of many further tachyon paradoxes (like J.Bell's, F.A.E.Pirani's, J.D.Edmonds' and others'). The key to the solution is a careful application of tachyon mechanics, as it unambiguously follows from special relativity. At Last, in one of the two Appendices, we propose how to evaluate the group-velocity in the case of evanescent waves. [PACS nos.: 03.30.+p; 03.50.De; 41.20.Jb; 73.40.Gk; 84.40.Az; 42.82.Et ]Comment: LaTeX file: 26 pages, with 5 Figures (and two Appendices). The original version of this paper appeared in the Journal below

Digital electric field induced switching of plasmonic nanorods using an electro-optic fluid fiber

We demonstrate the digital electric field induced switching of plasmonic nanorods between 1 and 0 orthogonal aligned states using an electro-optic fluid fiber component. We show by digitally switching the nanorods, that thermal rotational diffusion of the nanorods can be circumvented, demonstrating an approach to achieve submicrosecond switching times. We also show, from an initial unaligned state, that the nanorods can be aligned into the applied electric field direction in 110 nanoseconds. The high-speed digital switching of plasmonic nanorods integrated into an all-fiber optical component may provide novel opportunities for remote sensing and signaling applications

Evidences for Paleo-Gas Hydrate Occurrence: What We Can Infer for the Miocene of the Northern Apennines (Italy)

The occurrence of seep-carbonates associated with shallow gas hydrates is increasingly documented in modern continental margins but in fossil sediments the recognition of gas hydrates is still challenging for the lack of unequivocal proxies. Here, we combined multiple field and geochemical indicators for paleo-gas hydrate occurrence based on present-day analogues to investigate fossil seeps located in the northern Apennines. We recognized clathrite-like structures such as thin-layered, spongy and vuggy textures and microbreccias. Non-gravitational cementation fabrics and pinch-out terminations in cavities within the seep-carbonate deposits are ascribed to irregularly oriented dissociation of gas hydrates. Additional evidences for paleo-gas hydrates are provided by the large dimensions of seep-carbonate masses and by the association with sedimentary instability in the host sediments. We report heavy oxygen isotopic values in the examined seep-carbonates up to +6h that are indicative of a contribution of isotopically heavier fluids released by gas hydrate decomposition. The calculation of the stability field of methane hydrates for the northern Apennine wedge-foredeep system during the Miocene indicated the potential occurrence of shallow gas hydrates in the upper few tens of meters of sedimentary column

ISM studies of GRB 030329 with high resolution spectroscopy

We present a series of early UVES/VLT high resolution spectra of the afterglow of GRB 030329 at redshift z=0.16867+-0.00001. In contrast to other spectra from this burst, both emission and absorption lines were detected. None of them showed any temporal evolution. From the emission lines, we determine the properties of the host galaxy which has a star formation rate (SFR) of 0.198 M_solar yr^-1 and a low metallicity of 1/7 Z_solar. Given the low total stellar host mass M_star=10^7.75+-0.15 M_solar and an absolute luminosity m_V=-16.37, we derive specific SFRs (SSFR) of log SFR/M = -8.5 yr^-1 and SFR/L = 14.1 M_solar yr^-1 L_*^-1. This fits well into the picture of GRB hosts as being low mass, low metallicity, actively star forming galaxies. The MgII and MgI absorption lines from the host show multiple narrow (Doppler width b=5-10 km/s) components spanning a range of v about 260 km/s, mainly blueshifted compared to the redshift from the emission lines. These components are likely probing outflowing material of the host galaxy, which could arise from former galactic superwinds, driven by supernovae from star forming regions. Similar features have been observed in QSO spectra. The outflowing material is mainly neutral with high column densities of log N(MgII)=14.0+-0.1 cm^-2 and log N(MgI)=12.3+-0.1 cm^-2.Comment: 11 pages, 4 figures, submitted to Ap