Emperor Nicholas II and Tomsk University

The article is dedicated to the heir to the throne Nicholas Alexandrovich (the future Tsar Nicholas II) visiting Tomsk and the Imperial Tomsk University on July 5 and 6, 1891, while he was returning from his trip to the east. On the basis of the available scientific literature, documents, including those being introduced into scientific circulation for the first time, and the periodical press, the article reconstructs the history of the Tsar’s visit to Russia’s first higher education institution in Asia. The article is meant for those interested in the history of the Romanov kin as well as the history of higher learning and science in Russia

Alpha-Glutamyl-Tryptophan in the Treatment of Chronic Atrophic Gastritis, Associated with <em>Helicobacter pylori</em>

To evaluate the effectiveness of alpha-glutamyl-tryptophan as a cytoprotector in comparison with the control group (placebo) as part of the complex therapy of chronic atrophic H. pylori (HP)-associated gastritis. A total of 121 patients with chronic atrophic HP-associated gastritis were observed in 3 research centers. Before and after treatment blood test “Gastropanel”, stomach endoscopy with biopsies of atrophied mucosa for histological examination, rapid urease test for H. pylori detection, and daily pH-metry were performed. After HP eradication, according to randomization, the study drug (n = 61) or placebo (n = 60) was administered twice a day, in the morning 20–30 minutes before meals and in the evening before bedtime for 28 days. Alpha-glutamyl-tryptophan intake is associated with a statistically significant increase in acidity index according to pH-metry (p = 0.001), an increase in the ratio of pepsinogen I/pepsinogen II (p = 0.003), decrease in the level of gastrin-17 (p = 0.005), increase in the number of glands per 1 mm2 of the gastric mucosa (р = 0.028). Alpha-glutamyl-tryptophan in the treatment of chronic atrophic HP-associated gastritis has a superior regenerative effect compared with placebo, and promotes the restoration of acid-forming and pepsin-forming functions of the stomach