Long-term Cross-reactivity Against Nonvaccine Human Papillomavirus Types 31 and 45 After 2- or 3-Dose Schedules of the AS04-Adjuvanted Human HPV-16/18 Vaccine

This analysis focused on long-term cross-reactive immunogenicity against nonvaccine human papillomavirus (HPV) types 31 and 45 following 2 doses of AS04-adjuvanted HPV-16/18 vaccine in girls aged 9-14 years or following 3 doses in women aged 15-25 years, for up to 3 years (HPV-070 study) and up to 5 years (HPV-048 study) after the first vaccination. Both schedules elicited antibodies against HPV-31 and HPV-45 up to 5 years after first dose. The antibody concentration was similar in young girls as compared to women. Specific CD4+ T-cell and B-cell responses to HPV-31 and HPV-45 at month 36 were similar across groups. Clinical trials registration: NCT01381575 and NCT00541970

Sustained Immunogenicity of 2-dose Human Papillomavirus 16/18 AS04-adjuvanted Vaccine Schedules in Girls Aged 9-14 Years: A Randomized Trial

Background: We previously reported the noninferiority 1 month after the last dose of 2-dose human papillomavirus 16/18 AS04-adjuvanted (AS04-HPV-16/18) vaccine schedules at months 0 and 6 (2D_M0,6) and months 0 and 12 (2D_M0,12) in girls aged 9-14 years compared with a 3-dose schedule at months 0, 1, and 6 (3D_M0,1,6) in women aged 15-25 years. Here, we report the results at study end (month 36 [M36]).Methods: Girls were randomized 1:1 and received 2 vaccine doses either 6 months (2D_M0,6) or 12 months apart (2D_M0,12); women received 3 doses at months 0, 1, and 6 (3D_M0,1,6). Endpoints included noninferiority of HPV-16/18 antibodies for 2D_M0,6 versus 3D_M0,1,6; 2D_M0,12 versus 3D_M0,1,6; and 2D_M0,12 versus 2D_M0,6; and assessment of neutralizing antibodies, T cells, B cells, and safety.Results: At M36, the 2D_M0,6 and 2D_M0,12 schedules remained noninferior to the 3D_M0,1,6 schedule in terms of seroconversion rates and 3D/2D geometric mean titers for anti-HPV-16 and anti-HPV-18. All schedules elicited sustained immune responses up to M36.Conclusions: Both 2-dose schedules in young girls remained noninferior to the 3-dose schedule in women up to study conclusion at M36. The AS04-HPV-16/18 vaccine administered as a 2-dose schedule was immunogenic and well tolerated in young girls

Силовые параметры процесса плакирования прошивкой

Материалы XIV Междунар. науч.-техн. конф. студентов, аспирантов и молодых ученых, Гомель, 24–25 апр. 2014 г

Écrivains de l'Europe balkanique à Paris dans l'entre-deux-guerres

République des arts et des lettres, lieu de refuge, de création et de légitimation, Ville Lumière, Paris retrouve après l’hécatombe de la Grande Guerre le charme de la Belle-Époque des années 1900.Dans le contexte sociopolitique et culturel de l'entre deux-guerres, des écrivains de l’Europe balkanique affluent vers la Ville Lumière. Leur séjour parisien ayant beaucoup moins été étudié que celui d’écrivains d’autres horizons géolinguistiques, cette table ronde se propose d'apprécier la place occupée par l’imaginaire de la capitale française dans leurs œuvres, d’esquisser leurs réseaux de sociabilité ou encore de comprendre comment les courants esthétiques et idéologiques dominants ont influencé leur propre création

Écrivains de l'Europe balkanique à Paris dans l'entre-deux-guerres

République des arts et des lettres, lieu de refuge, de création et de légitimation, Ville Lumière, Paris retrouve après l’hécatombe de la Grande Guerre le charme de la Belle-Époque des années 1900.Dans le contexte sociopolitique et culturel de l'entre deux-guerres, des écrivains de l’Europe balkanique affluent vers la Ville Lumière. Leur séjour parisien ayant beaucoup moins été étudié que celui d’écrivains d’autres horizons géolinguistiques, cette table ronde se propose d'apprécier la place occupée par l’imaginaire de la capitale française dans leurs œuvres, d’esquisser leurs réseaux de sociabilité ou encore de comprendre comment les courants esthétiques et idéologiques dominants ont influencé leur propre création

La littérature roumaine, 30 ans après 1989

Une table ronde avec Dan Lungu, Cécile Folschweiller et Laure Hinckel. Les trois intervenants examinent les métamorphoses à l'œuvre dans la littérature roumaine provoquées par les bouleversements politiques, économiques, sociaux... à partir de la chute du mur de Berlin et l'effondrement du bloc soviétique. Ils s'intéressent notamment à la place occupée par la littérature dans la société roumaine actuelle, de même qu'à l'émergence de nouvelles thématiques (l'année 1989 et les années de transition sont-elles devenues des motifs littéraires ?) ainsi qu'aux nouvelles écritures (peut-on parler d'une Nouvelle Vague littéraire en Roumanie ?). L'exemple des romans de Dan Lungu permet d'illustrer et d'étayer les divers aspects du débat. La table ronde est animée par Nicolas Pitsos, responsable de l'équipe Europe balkanique, centrale et orientale de la BULAC et enseignant-chercheur dans ce domaine

The interaction between pyoverdin and its outer membrane receptor in Pseudomonas aeruginosa leads to different conformers: a time-resolved fluorescence study.

In iron limitation conditions, Pseudomonas aeruginosa secretes a major fluorescent siderophore named pyoverdin (PaA). PaA has an extremely high affinity for Fe(3+) but also chelates other ions such as Al(3+) and Ga(3+) with a lower affinity. The transfer of PaA-Fe(3+) across the outer membrane of the bacteria is mediated by the receptor FpvA, a TonB-dependent outer membrane transport protein. FpvA binds the iron-free and iron-loaded forms of pyoverdin with similar affinities, but only PaA-Fe(3+) is taken up by the cell, suggesting that FpvA adopts different conformations depending on its loading status. We used time-resolved fluorescence spectroscopy to characterize the different forms of FpvA-PaA in vitro. We showed that the FpvA-PaA complex adopts two different conformations depending on how it was prepared (formed in vitro or in vivo prior to purification). The dihydroquinoline moiety of both conformers is fully protonated, or coordinated by protein charged groups, but the polarity of its environment, its solvent accessibility, and its rotational dynamics are much slower when the FpvA-PaA complex is formed in vivo than in vitro. In the presence of Ga(3+) or Al(3+) ions, the solvent accessibility and mobility of the dihydroquinoline moiety in the two FpvA-PaA complexes are intermediate between those observed for the metal-free ones. In addition, the F?er resonance energy transfer kinetics from FpvA tryptophan residues to the PaA chromophore differs from one complex to the other, revealing differences in one or more of the donor-acceptor topologies

Persistence of antibodies 20 y after vaccination with a combined hepatitis A and B vaccine

Vaccination is the most effective and well-tolerated method of conferring long-term protection against hepatitis A and B viruses (HAV; HBV). Long-term studies are required to characterize the duration of protection and need for boosters. Following primary immunization of 150 and 157 healthy adults with 3-doses of combined hepatitis A/hepatitis B vaccine (HAB; Twinrix™, GSK Vaccines, Belgium) at 0-1-6 months in 2 separate studies, we measured vaccine-induced antibody persistence against HAV and HBV annually for 20 y (Study A: NCT01000324; Study B: NCT01037114). Subjects with circulating anti-HAV antibodies < 15 mIU/mL or with anti-hepatitis B surface antigen < 10 mIU/mL were offered an additional monovalent hepatitis A and/or B vaccine dose (Havrix™/Engerix™-B, GSK Vaccines, Belgium). Applying the immunogenicity results from these studies, mathematical modeling predicted long-term persistence. After 20 y, 18 and 25 subjects in studies A and B, respectively, comprised the long-term according-to-protocol cohort for immunogenicity; 100% and 96.0% retained anti-HAV antibodies ≥ 15 mIU/mL, respectively; 94.4% and 92.0% had anti-HBs antibodies ≥ 10 mIU/mL, respectively. Between Years 16–20, 4 subjects who received a challenge dose of monovalent hepatitis A vaccine (N = 2) or hepatitis B vaccine (N = 2), all mounted a strong anamnestic response suggestive of immune memory despite low antibody levels. Mathematical modeling predicts that 40 y after vaccination ≥ 97% vaccinees will maintain anti-HAV ≥ 15 mIU/mL and ≥ 50% vaccinees will retain anti-HBs ≥ 10 mIU/mL. Immunogenicity data confirm that primary immunization with 3-doses of HAB induces persisting anti-HAV and anti-HBs specific antibodies in most adults for up to 20 y; mathematical modeling predicts even longer-term protection

Belgian Red List of Bees

Belgian Science Policy 2018 (BRAIN-be - (Belgian Research Action through Interdisciplinary Networks)