Building Interdisciplinary Learning Partnerships

Capital University Law School & Grant Medical Center partnered to provide training on medical malpractice to law students and medical residents. The course utilized a unique, interdisciplinary approach to skills training & professional development. The course attempts to meet several needs: (1) Increase experiential learning opportunities to develop professional skills and judgment; (2) Provide authentic, experiential learning that is cost-effective and accessible to all law students, including non-traditional and part­time students; and (3) Promote interdisciplinary education.https://fuse.franklin.edu/ss2016/1066/thumbnail.jp

Laterally Propagating Detonations in Thin Helium Layers on Accreting White Dwarfs

Theoretical work has shown that intermediate mass (0.01Msun<M_He<0.1Msun) Helium shells will unstably ignite on the accreting white dwarf (WD) in an AM CVn binary. For more massive (M>0.8Msun) WDs, these helium shells can be dense enough (5x10^5 g/cc) that the convectively burning region runs away on a timescale comparable to the sound travel time across the shell; raising the possibility for an explosive outcome. The nature of the explosion (i.e. deflagration or detonation) remains ambiguous. In the case of detonation, this causes a laterally propagating front whose properties in these geometrically thin and low density shells we begin to study here. Our calculations show that the radial expansion time of <0.1 s leads to incomplete helium burning, in agreement with recent work by Sim and collaborators, but that the nuclear energy released is still adequate to realize a self-sustaining detonation propagating laterally at slower than the Chapman-Jouguet speed. Our simulations resolve the subsonic region behind the front and are consistent with a direct computation of the reaction structure from the shock strength. The ashes are typically He rich, and consist of predominantly Ti-44, Cr-48, along with a small amount of Fe-52, with very little Ni-56 and with significant Ca-40 in carbon-enriched layers. If this helium detonation results in a Type Ia Supernova, its spectral signatures would appear for the first few days after explosion. (abridged)Comment: 7 pages, 5 figure, accepted to the Astrophysical Journa

The Impact of baseline 18F-FDG PET-CT on the management and outcome of patients with gastric cancer: a systematic review

Objective: CT and staging laparoscopy are routinely used to stage patients with gastric cancer, however the role of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with CT (PET-CT) is uncertain. This systematic review synthesised the evidence regarding the impact of baseline PET-CT staging on treatment decisions and patient outcomes. Methods: Systematic database searches were performed without date restriction. Studies reporting data in patients with gastric adenocarcinoma who underwent radiological staging were included. One reviewer screened titles and abstracts for suitability and two reviewers extracted data from included articles. Primary outcome was the reported change in management after PET-CT. Secondary outcomes were the rates of recurrence and overall survival between patients staged with and without PET-CT. Risk of bias was assessed using the ROBINS-I tool. PROSPERO registration (CRD42022304314). Results: Data from 11 studies recruiting 2101 patients between 2012 and 2021 were included. PET-CT was performed in 1422 patients. Change of management varied between 3% and 29% of cases. No studies compared recurrence or survival rates between patients staged with or without PET-CT. Adenocarcinoma of intestinal subtype tended to be more FDG-avid compared to diffuse or signet-ring subtypes. No randomised data existed, and studies were considered low quality with high risk of bias. Conclusion: Evidence for the additional value of PET-CT in the gastric cancer staging pathway is limited. All studies reported a positive impact by preventing those with undetected metastatic disease on CT undergoing futile surgery. Future national guidelines should consider routine staging PET-CT in gastric cancer

Believe in You student empowerment program: A pilot study

IntroductionThe social and emotional health of youth is important, especially after students experience the COVID-19 pandemic. The purpose of this study was to understand the influence that the Believe In You Student Empowerment Program had on students social emotional learning (SEL) behaviors over a 10 week period during the COVID-19 pandemic.Materials and methodsA part of this quantitative study, one school in each the intervention and the control group (delayed intervention; 2 schools total) participated in the study. Students enrolled in physical education within each school participated (n = 166; Intervention = 88). Students in each group took a survey at week 1 (baseline measure), week 5, and week 10. Students who were in the intervention group started the program after week 1, while the delayed intervention group began the program in week 5.ResultsA series of ANCOVA's examined the difference of social emotional learning knowledge and social emotional learning scales between the treatment and control groups. Self-awareness (F = 13.91, p &lt; .01), self-management (F = 6.14, p &lt; .01) &amp; relationship skills (F = 5.50, p &lt; .05) saw significant differences over time compared to the control group. The second series of analyses looked only at the intervention group and analyzed to determine significant differences in mean scores of SEL variables between weeks one and ten. Emotional regulation saw significant differences (t = 2.5, p &lt; .01). The final set of analyses conducted were with the delayed intervention group and examined the difference in mean SEL scores over the three time periods. Again, emotional regulation saw significance with an interaction of time and gender (F = 4.162, p &lt; .01).Discussion and ConclusionIn a short period of time, Believe in You Student Empowerment Program has shown the potential to have a positive influence on students social emotional learning behaviors, even during the COVID-19 pandemic. More research should be conducted over a longer period of time, in-person, and with an experimental design to better understand the effects of the Varsity Brands Believe in You Student Empowerment Program and its implications with student social emotional learning behaviors

Polynitroxyl Albumin and Albumin Therapy After Pediatric Asphyxial Cardia Arrest: Effects on Cerebral Blood Flow and Neurologic Outcome

Postresuscitation cerebral blood flow (CBF) disturbances and generation of reactive oxygen species likely contribute to impaired neurologic outcome after pediatric cardiac arrest (CA). Hence, we determined the effects of the antioxidant colloid polynitroxyl albumin (PNA) versus albumin or normal saline (NS) on CBF and neurologic outcome after asphyxial CA in immature rats. We induced asphyxia for 9 minutes in male and female postnatal day 16 to 18 rats randomized to receive PNA, albumin, or NS at resuscitation from CA or sham surgery. Regional CBF was measured serially from 5 to 150 minutes after resuscitation by arterial spin-labeled magnetic resonance imaging. We assessed motor function (beam balance and inclined plane), spatial memory retention (water maze), and hippocampal neuronal survival. Polynitroxyl albumin reduced early hyperemia seen 5 minutes after CA. In contrast, albumin markedly increased and prolonged hyperemia. In the delayed period after resuscitation (90 to 150 minutes), CBF was comparable among groups. Both PNA- and albumin-treated rats performed better in the water maze versus NS after CA. This benefit was observed only in males. Hippocampal neuron survival was similar between injury groups. Treatment of immature rats with PNA or albumin resulted in divergent acute changes in CBF, but both improved spatial memory retention in males after asphyxial CA

Supernova Cosmology and the ESSENCE project

The proper usage of Type Ia supernovae (SNe Ia) as distance indicators has revolutionized cosmology, and added a new dominant component to the energy density of the Universe, dark energy. Following the discovery and confirmation era, the currently ongoing SNe Ia surveys aim to determine the properties of the dark energy. ESSENCE is a five year ground-based supernova survey aimed at finding and characterizing 200 SNe Ia in the redshift domain z=[0.2-0.8]. The goal of the project is to put constraints on the equation of state parameter, w, of the dark energy with an accuracy of <10%. This paper presents these ongoing efforts in the context of the current developments in observational cosmology.Comment: Submitted to EPS1

Hubble Space Telescope Observations of Nine High-Redshift ESSENCE Supernovae

We present broad-band light curves of nine supernovae ranging in redshift from 0.5 to 0.8. The supernovae were discovered as part of the ESSENCE project, and the light curves are a combination of Cerro Tololo 4-m and Hubble Space Telescope (HST) photometry. On the basis of spectra and/or light-curve fitting, eight of these objects are definitely Type Ia supernovae, while the classification of one is problematic. The ESSENCE project is a five-year endeavor to discover about 200 high-redshift Type Ia supernovae, with the goal of tightly constraining the time average of the equation-of-state parameter [w = p/(rho c^2)] of the "dark energy." To help minimize our systematic errors, all of our ground-based photometry is obtained with the same telescope and instrument. In 2003 the highest-redshift subset of ESSENCE supernovae was selected for detailed study with HST. Here we present the first photometric results of the survey. We find that all but one of the ESSENCE SNe have slowly declining light curves, and the sample is not representative of the low-redshift set of ESSENCE Type Ia supernovae. This is unlikely to be a sign of evolution in the population. We attribute the decline-rate distribution of HST events to a selection bias at the high-redshift edge of our sample and find that such a bias will infect other magnitude-limited SN Ia searches unless appropriate precautions are taken.Comment: 62 pages, 18 numbered figures, accepted for publication in the Astronomical Journa