SEPARATION OF OPTICAL ISOMERS VIA DIASTEREOISOMERIC SALT FORMATION

The optical resolution processes were systematically investigated. The optimum of the parameters of the diastereoisomeric salt formation can be determined by using a thermodynamic equilibrium model. Based upon the conformational analysis of the structure for diastereo isomeric salts, a new method has been elaborated for designing optical resolutions

Synthesis, Characterization and Application of Platinum(II) Complexes Incorporating Racemic and Optically Active 1-Phenyl-1,2,3,6-Tetrahydrophosphinine Ligand

An efficient resolution method was elaborated for the preparation of (+)-4-chloro-5-methyl-1-phenyl-1,2,3,6-tetrahydrophosphinine oxide using the acidic Ca2+ salt of (–)-O,O-di-p-toluoyl-(2R,3R)-tartaric acid. Crystal structure of the diastereomeric complex was evaluated by single crystal X-ray analysis. Beside this, the absolute P-configuration was also determined by a CD spectroscopic study including theoretical calculations. The tetrahydrophosphinine oxide was then converted to the corresponding platinum complex whose stereostructure was investigated by high level quantum chemical calculations. The Pt-complex was tested as catalyst in the hydroformylation of styrene