373 research outputs found

    From a Mirage to an Oasis: Narcissism, Perceived Creativity, and Creative Performance

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    We examine the link between narcissism and creativity at the individual, relational, and group levels of analysis. We find that narcissists are not necessarily more creative than others but they think they are, and they are adept at convincing others to agree with them. In the first study, narcissism was positively associated with self-rated creativity, despite the fact that blind coders saw no difference between the creative products offered by those low and high on narcissism. In a second study, more narcissistic individuals asked to pitch creative ideas to a target person were judged by the targets as being more creative than were less narcissistic individuals, in part because narcissists were more enthusiastic. Finally, in a study of group creativity, we find evidence of a curvilinear effect: having more narcissists is better for generating creative outcomes (but having too many provides diminishing returns)

    Intrinsic Domain and Loop Dynamics Commensurate with Catalytic Turnover in an Induced-Fit Enzyme

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    SummaryArginine kinase catalyzes reversible phosphoryl transfer between ATP and arginine, buffering cellular ATP concentrations. Structures of substrate-free and -bound enzyme have highlighted a range of conformational changes thought to occur during the catalytic cycle. Here, NMR is used to characterize the intrinsic backbone dynamics over multiple timescales. Relaxation dispersion indicates rigid-body motion of the N-terminal domain and flexible dynamics in the I182–G209 loop, both at millisecond rates commensurate with kcat, implying that either might be rate limiting upon catalysis. Lipari-Szabo analysis indicates backbone flexibility on the nanosecond timescale in the V308–V322 loop, while the rest of the enzyme is more rigid in this timescale. Thus, intrinsic dynamics are most prominent in regions that have been independently implicated in conformational changes. Substrate-free enzyme may sample an ensemble of different conformations, of which a subset is selected upon substrate binding, with critical active site residues appropriately configured for binding and catalysis

    A Surface Modification Decision Tree to Influence Design in Additive Manufacturing

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    Additive manufacturing (AM) presents a very different set of design challenges to traditional manufacturing. Layer-wise building brings about issues with residual stresses and support requirements which lead to failures during processing of poorly-designed parts. Additionally, there is a need for post-processing due to poor part quality, which adds another process to the chain with its own unique design limitations. This paper discusses the issues surrounding designing for AM and the subsequent post-processing. A future vision is proposed for the selection of post-processes and the relative design adjustments to accommodate the chosen techniques. A decision tree is presented as a framework for process selection based on part requirements. Although at present, the data necessary to realise this vision is incomplete, with further research into the capabilities and design constraints of different post-processes, this approach could provide a systematic method for integrating design for post-processing with AM design

    The Role of Attachment Style, Adverse Childhood Experiences and Dissociation in Migraine

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    35 pagesMigraine and chronic migraine are caused by a combination of modifiable and non-modifiable genetic, social, behavioral and environmental risk factors. Further research of possible modifiable risk factors for this headache disorder is merited, given its role as one of the leading causes of years lived with disability per year. The first aim of this online cross-sectional study was to investigate the psychosocial risk factors that predicted chronic migraine and severe migraine-related disability in 507 Irish and UK participants, focusing specifically on childhood maltreatment, attachment and tendency to dissociate, or experience depressed mood and/or anxiety. Additionally, this study aimed to examine variables that mediated the relationships between these psychosocial risk factors and migraine chronicity or severe migraine-related disability. Adjusted binary logistic regression revealed that shutdown dissociation (Odds Ratio [OR] 4.57, 95% Confidence Interval [CI] 2.66–7.85) and severe physical abuse (OR 4.30, 95% CI 1.44–12.83 had significant odds of predicting migraine chronicity, while depression (OR 3.28, 95% CI 1.86–5.77) significantly predicted severe migraine-related disability. Mediation analyses indicated that shutdown dissociation mediated the relationship between seven predictor variables and both chronicity and severe disability including possible predisposing factors emotional abuse, physical neglect, avoidant attachment and anxious attachment. These findings suggest that early life stressors (such as childhood trauma and avoidant attachment style), shutdown dissociation and depression may impact on migraine trajectory. To investigate whether these psychosocial factors are risk factors for migraine chronicity or disability, prospective research should be conducted in this area to account for fluctuations in migraine chronicity over time

    Ariel - Volume 2 Number 3

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    Editors Delvyn C. Case, Jr. Paul M. Fernhoff News Editors Richard Bonanno Daniel B. Gould Robin A. Edwards Lay-Out Editor Carol Dolinskas Sports Editor James J. Nocon Contributing Editors Michael J. Blecker Lin Sey Edwards Jack Guralnik W. Cherry Light Features Editor Steven A. Ager Donald A. Bergman Stephen P. Flynn Business Manager Nick Greg

    Water Walls Architecture: Massively Redundant And Highly Reliable Life Support For Long Duration Exploration Missions

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    The Water Wall concept proposes a system for structural elements that provide,thermal, radiation, water, solids and air treatment functions which are placed at the periphery of inflatable or rigid habitats. It also provides novel and potentially game changing mass reduction and reuse options for radiation protection. The approach would allow water recycling, air treatment, thermal control, and solids residuals treatment and recycling to be removed from the usable habitat volume, and placed in the walls by way of a radiation shielding water wall. It would also provide a mechanism to recover and reuse water treatment (solids) residuals to strengthen the habitat shell and a method of deriving radiation shielding from wastes generated on orbit. Water wall treatment elements would be a much-enlarged version of the commercially available hydration bags. Some water bags may have pervaporation membranes facing outward, which would provide the ability to remove H20, C02 and trace organics from the atmosphere and some would have hydrophobic internal membranes which would provide water, and waste recycling and some power generation

    Perspective: A Magazine for Different People

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    Perspective was published by undergraduate students at UND in April 1978. The lone issue featured articles about the culture and history of Sioux Indians, an interview with an African student and an African-American student, domestic abuse of women, the development of new energy resources in North Dakota, and the new Hughes Fine Arts Center. Photographs, cartoons, poetry and prose were also included.https://commons.und.edu/und-books/1065/thumbnail.jp

    Delivering routine immunisations in London during the COVID-19 pandemic: lessons for future vaccine delivery. A mixed-methods study.

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    BACKGROUND: General practices in England have continued to care for patients throughout the COVID-19 pandemic by instigating major changes to service delivery. Immunisations have continued, although the number of vaccines delivered initially dropped in April 2020. AIM: To evaluate how COVID-19 impacted the delivery of immunisations in London and identify innovative practices to inform future delivery, including for COVID-19 vaccines. DESIGN & SETTING: A mixed-methods study of immunisation delivery in London, UK. METHOD: An online survey of London general practices was undertaken in May 2020 to produce a descriptive analysis of childhood immunisation delivery and identify innovative delivery models. Semi-structured interviews were conducted between August and November 2020 to explore innovative immunisation models, which were analysed thematically. RESULTS: Sixty-eight per cent (n = 830) of London practices completed the survey and 97% reported having continued childhood immunisation delivery. Common delivery adaptations included spaced-out appointments, calling parents beforehand, and having only one parent attend. Forty-three practices were identified as having innovative models, such as delivering immunisations outside practice buildings or offering drive-through services. The thematic analysis of 14 semi-structured interviews found that, alongside adaptations to immunisation delivery within practices, existing local networks collaborated to establish new immunisation delivery models. Local population characteristics affected delivery and provide insights for large-scale vaccine deployment. CONCLUSION: Immunisations continued during 2020 with practices adapting existing services. New delivery models were developed by building on existing local knowledge, experiences, and networks. Immunisation delivery during the pandemic, including for COVID-19 vaccines, should be tailored to local population needs by building on primary care immunisation expertise
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