Antipersistent binary time series

Completely antipersistent binary time series are sequences in which every time that an $N$-bit string $\mu$ appears, the sequence is continued with a different bit than at the last occurrence of $\mu$. This dynamics is phrased in terms of a walk on a DeBruijn graph, and properties of transients and cycles are studied. The predictability of the generated time series for an observer who sees a longer or shorter time window is investigated also for sequences that are not completely antipersistent.Comment: 6 pages, 6 figure

FK 506 ameliorates the hepatic injury associated with ischemia and reperfusion in rats

The effect of FK 506 on regeneration of the liver was studied in rats after a two‐thirds partial hepatectomy after 60 min of ischemia of the unresected liver. The animals were divided into three distinct groups of 10 rats each. Group 1 (controls) received 0.5 ml saline solution intravenously 30 min after the induction of ischemia. Groups 2 and 3 were injected with FK 506 (0.3 mg/kg) intravenously 30 min after and 24 min before the induction of hepatic ischemia, respectively. The hepatic content of ATP and serum levels of ALT and lactate dehydrogenase were determined on each animal. In addition, the histological appearance and mitotic activity of the remnant liver was determined at regular 24‐hr intervals after hepatic ischemia. All 10 control animals died within 72 hr. Treatment with FK 506 resulted in improved survival in groups 2 and 3 (30% and 80%, respectively). The improved survival seen in the FK 506–treated animals was reflected by a restoration of hepatic ATP content, a reduction in the serum levels of ALT and lactate dehydrogenase, an amelioration of hepatic necrosis and neutrophilic infiltration and an increase in the mitotic activity of the liver. These results suggest that FK 506 ameliorates the hepatic injury associated with ischemia/reperfusion and has a potent stimulatory effect on liver cell regeneration that may make it valuable as a hepatoprotective agent when administered to organ donors before graft harvesting. (HEPATOLOGY 1991;13:947–951.) Copyright © 1991 American Association for the Study of Liver Disease

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives

© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).A number of 1,2-benzothiazines have been synthesized in a three-step process. Nine chalcones 1-9 bearing methyl, fluoro, chloro and bromo substituents were chlorosulfonated with chlorosulfonic acid to generate the chalcone sulfonyl chlorides 10-18. These were converted to the dibromo compounds 19-27 through reaction with bromine in glacial acetic acid. Compounds 19-27 were reacted with ammonia, methylamine, ethylamine, aniline and benzylamine to generate a library of forty-five 1,2-benzothiazines 28-72. Compounds 28-72 were evaluated for their antimicrobial activity using broth micro dilution techniques against two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), and two Gram-negative bacteria (Proteus vulgaris and Salmonella typhimurium). The results demonstrated that none of the compounds showed any activity against Gram-negative bacteria, P. vulgaris and S. typhimurium, however compounds 31, 33, 38, 43, 45, 50, 53, 55, 58, 60, 63 and 68 showed activity against Gram-positive bacteria, Bacillus subtilis and Staphylococcous aureus. The range of MIC and MBC was 25-600µg/ml; though some of the MIC and MBC concentrations were high indicating weak activity. Structure activity relationship studies revealed that the compounds with a hydrogen atom or an ethyl group on the nitrogen of the thiazine ring exerted antibacterial activity against Gram-positive bacteria. The results also showed that the compounds where the benzene ring of the benzoyl moiety contained a methyl group or chlorine or bromine atom in the para position showed higher antimicrobial activity. Similar influences were identified where either a bromine or chlorine atom was in the meta position.Peer reviewedFinal Published versio

Deciphering the molecular adaptation of the king scallop (Pecten maximus) to heat stress using transcriptomics and proteomics

Background The capacity of marine species to survive chronic heat stress underpins their ability to survive warming oceans as a result of climate change. In this study RNA-Seq and 2-DE proteomics were employed to decipher the molecular response of the sub-tidal bivalve Pecten maximus, to elevated temperatures. Results Individuals were maintained at three different temperatures (15, 21 and 25 °C) for 56 days, representing control conditions, maximum environmental temperature and extreme warming, with individuals sampled at seven time points. The scallops thrived at 21 °C, but suffered a reduction in condition at 25 °C. RNA-Seq analyses produced 26,064 assembled contigs, of which 531 were differentially expressed, with putative annotation assigned to 177 transcripts. The proteomic approach identified 24 differentially expressed proteins, with nine identified by mass spectrometry. Network analysis of these results indicated a pivotal role for GAPDH and AP-1 signalling pathways. Data also suggested a remodelling of the cell structure, as revealed by the differential expression of genes involved in the cytoskeleton and cell membrane and a reduction in DNA repair. They also indicated the diversion of energetic metabolism towards the mobilization of lipid energy reserves to fuel the increased metabolic rate at the higher temperature. Conclusions This work provides preliminary insights into the response of P. maximus to chronic heat stress and provides a basis for future studies examining the tipping points and energetic trade-offs of scallop culture in warming oceans

An Analysis Of The Selection, Placement And Follow-Up Procedures Of The Industrial Cooperative Training Programs In Texas

The chief factors in determining the efficiency of a cooperative education program are as follows: (1) the quality of the students selected (2) the placement of the student trainee and (3) the follow-up report of the students once they have graduated from high school. The guidance service, school records, and faculty recommendations are the services that should be made available and utilized by the teacher-coordinator when seeking prospective students. Barba H. Kemp states that conscientious efforts should be made to match the job to the student with appropriate interest and ability, and the possibility of career motivation resulting from these placements should be considered very seriously. In determining the quality of students to be selected for a cooperative program, students who have made grades of all A\u27s are not necessarily best qualified; however, those students who have the aptitude and qualification should be given priority. THE PROBLEM Statement of the Problem. For the young or inexperienced coordinator, it can become extremely difficult to: (1) select the student for enrollment into cooperative classes (2) place the student-trainees and (3) do an accurate follow-up survey on the graduating seniors. It is anticipated that the result of the findings will give some insight into the following question: 1. How does Texas differ from the states selected for the study in selecting cooperative students? 2. What are the techniques used in placing students? 3. What are the techniques used in making an accurate follow-up report

A Comparative Analysis of Student Participation in the Advancement Via Individual Determination(AVID) Program and Performance on the Grade 11 Michigan Merit Exam (MME)

The Advancement Via Individual Determination (AVID) curriculum emphasizes writing, collaboration, organization, and reading to strengthen academic skills. High school students enrolled in AVID elective classes receive daily academic support, while enrolled in challenging classes such as Advanced Placement (AP). The purpose of this study was to examine the influence of Academic High School students’ participation in the AVID college readiness system and students’ academic achievement using multiple measures, including the Michigan Merit Exam (MME) state assessment, the American College Test (ACT) college readiness assessment, the Advanced Placement (AP) program, and grade point average (GPA). Vroom’s (1964) expectancy theory comprised the theoretical framework for this study. A longitudinal, correlational design used previously collected data from three cohorts of graduates (2012‒13, 2013‒14, and 2014‒15) to determine the effect of students’ participation in AVID based on the selected academic indicators. Students enrolled in the AVID program and a control group in each cohort were matched on grade, gender, socioeconomic status and compared on the academic indicators. Findings confirmed that although students in the AVID group showed slightly higher student achievement scores in ACT English assessment, Number of AP English courses, and GPA, no statistically significant differences were found for ACT English and reading tests, AP English and mathematics courses, or senior GPA. Based on analysis of findings in this study, the AVID program did not positively influence student achievement at Academic High School. The school district must carefully weigh the associated costs and benefits of the AVID program while considering the recommendations in this study for practice and/or policy

A structural equation model: Family-friendly organizational policies, norms, supervisory support, work/family conflict and organizational attachment

The purpose of this paper is to present a study that examines the underlying stucture of work/family conflict. Research has shown that reducing work/family conflict is beneficial to both employees and the organization by reducing turnover and increasing satisfction, production and commitment to the organization