Vertiges archéologiques et politique du rire

À partir de son expérience muséale, l’auteur confronte les difficultés de la démarche archéologique, considérée comme interprétative, empirique et subjective, à une autocritique comique dans laquelle l’humour et la parodie, en pimentant le discours muséographique, incitent le visiteur à prendre davantage de recul

Factores de riesgo asociados a infección del sitio quirúrgico posterior a cesárea en el Hospital Berta calderon Roque en el año 2006.

Tesis (Doctor en Medicina y Cirugia)--Universidad Americana, Managua, 2007Identificar los principales factores de riesgo asociados a infección del sitio quirúrgico posterior a Cesárea en el Hospital Berta Calderón Roque del año 2006, así como también los factores de riesgo obstétricos que se presentaron durante el embarazo y trabajo de parto, es un tipo de estudio analítico, de Caso-Control, en pacientes sometidas a Cesáreas en el Hospital Berta Calderón Roque conformado por 16 pacientes que presentaron infección del sitio quirúrgico posterior a cesárea

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

Intrinsically disordered proteins/regions (IDPs/IDRs) are proteins or peptide segments that fail to form stable 3-dimensional structures in the absence of partner proteins. They are abundant in eukaryotic proteomes and are often associated with human diseases, but their biological functions have been elusive to study. In this study, we report the identification of a tin(IV) oxochloride-derived cluster that binds an evolutionarily conserved IDR within the metazoan TFIID transcription complex. Binding arrests an isomerization of promoter-bound TFIID that is required for the engagement of Pol II during the first (de novo) round of transcription initiation. However, the specific chemical probe does not affect reinitiation, which requires the re-entry of Pol II, thus, mechanistically distinguishing these two modes of transcription initiation. This work also suggests a new avenue for targeting the elusive IDRs by harnessing certain features of metal-based complexes for mechanistic studies, and for the development of novel pharmaceutical interventions.National Cancer Institute (U.S.). Initiative for Chemical Genetics (Contract N01-CO-12400)National Cancer Institute (U.S.). Cancer Target Discovery and Development Network (R01 CA160860