Lydfesting av Tor Egil Langnes sine viser: En del av Nordmøres kulturarv

Denne masteroppgaven beskriver et møte mellom to generasjoner, som finner sammen om felles interesser. Her redegjør forfatteren for hvordan han og Tor Egil Langnes har jobbet med å lydfeste visene hans. Dette er et kunstnerisk forskningsprosjekt og dermed en todelt studie. Den kunstneriske delen består av tre innspillinger; «Thamshavnbanen», «Kjølvassroinna» og «Mamma si hand», mens den skriftlige delen inneholder beskrivelser og refleksjoner rundt arbeidet. Dette er praksisbasert forskning hvor den kunstneriske aktiviteten står i sentrum. Det kommenteres også hvordan framveksten av ny digital teknologi, har ført til en evolusjon i den kreative prosessen og en naturlig utvidelse av steder og rom hvor musikk kan bli innspilt og presentert. Dermed er denne studien med på å dokumentere bredden i feltet, ved å være et eksempel på nåværende praksis innen musikkskaping

Presisjonsmedisin i behandling av akutt myelogen leukemi - status i dag, utfordringer og rolle i fremtidens kreftterapi

Bakgrunn: Akutt myelogen leukemi (AML) er en kompleks og heterogen sykdom karakterisert av ukontrollert vekst og proliferasjon av myeloide forløperceller. Siden standardbehandling av AML med cytarabin og antrasyklin ble introdusert for rundt 50 år siden, har dette regimet blitt brukt i behandlingen av stort sett alle AML-pasienter. Sykdommen er preget av dårlig prognose, høy behandlingsrelatert dødelighet og lav overlevelse, spesielt hos eldre. Behovet for nye behandlingsmetoder er derfor stort. Metode: Litteraturen er funnet ved hjelp av ett hovedsøk og flere mer spesifikke søk i PubMed. Artiklene ble selektert gjennom en trinnvis prosess med lesing av titler, sammendrag og fulltekst for å vurdere om de kunne bidra til å besvare oppgavens problemstilling. I tillegg ble referanselistene til artiklene studert, og relevante artikler inkludert i oppgaven. Resultater: Denne litteraturstudien legger frem en oppdatert oversikt over mutasjonslandskapet ved AML, de ulike mutasjonenes prognostiske verdi og de mest sentrale presisjonslegemidlene rettet mot disse. Oppgaven omtaler elleve presisjonslegemidler som de siste årene har blitt godkjent av FDA for behandling av AML, i tillegg til å diskutere ulike utfordringer ved de nye behandlingsmetodene og deres rolle i fremtiden. Konklusjon: Den raske utviklingen av presisjonslegemidler de to siste tiårene har gitt et bedre behandlingstilbud og bedret overlevelsen for mange AML-pasienter. De nye behandlingsmetodene medfører imidlertid flere utfordringer, blant annet knyttet til resistensutvikling, kostnader og logistikk. Videre forskning på leukemisk stamcellebiologi og legemiddelresistens, samt standardisering av både utredning, behandlingsregimer og studier er derfor nødvendig. Til tross for dette er det mye som tyder på at presisjonsmedisin vil spille en avgjørende rolle for å kunne tilby trygg og effektiv behandling av AML i fremtiden

Investigation of the relationships between laser energy and vaporized target material, continuum intensity, and plume energy in laser plume spectroscopy

A focused Q-switched neodymium-doped glass laser with power levels ranging from 1-6 MW and with a 50-nsec halfwidth, was used to vaporize copper metal. Experimental measurements showed that the amount of material vaporized away from the target was not linear with laser power and was much less than could be accounted for by the laser energy available. Amounts of copper in the 0.0X μg range were measured for the power range investigated. Experimental methods are described to monitor the power and energy of the laser beam as the target material was vaporized and collected for measurement. Photodiode monitors were built to measure simultaneously the plume plasma continuum intensity and the laser beam power and energy. The measurements showed a linear increase in the plume continuum emission as a function of laser beam power. The total emission seen by the photodiode was shown to be approximately linearly related to the energy transferred to the plume plasma. The energy that could not be accounted for by the vaporized material was shown, using reasonable assumptions, to be governed by the laser beam energy losses to the plume plasma. The shape of the theoretically calculated curve was found to be consistent with the experimental measurements, giving evidence that energy is being transferred to the plume plasma approximately linearly as a function of laser beam power. This energy might otherwise have been used in vaporizing target material for analytical purposes

Dual frequency master oscillator generation and distribution for ALS and ALS-U

The ongoing work to upgrade ALS to ALS-U demands strict RF requirements such as low jitter and low spurs frequency reference to meet its accelerator and science goals. A low phase noise dual frequency Master Oscillator (MO), where the two frequencies are related by a fractional ratio of 608/609 and flexible divide by four frequency outputs has been consolidated into a single chassis. Optical fiber clock distribution system has been selected over the old coax system used in ALS to distribute these signals to various clients across the facility, providing high electrical isolation between outputs and therefore lower phase errors. A Xilinx FPGA ties the MO chassis together by providing a RS-485 interface to monitor and control the system. The new system aims to deliver phase-continuous frequencies with a phase noise (integrated RMS jitter) from 1 Hz to 1 MHz of less than 200 femtosecond per output. This paper will discuss the design, implementation, performance and installation of the new MO generation and distribution system.Comment: Poster presented at LLRF Workshop 2023 (LLRF2023, arXiv: 2310.03199

Rivaroxaban for Venous Thromboembolism Prophylaxis in Abdominoplasty: A Multicenter Experience

BACKGROUND: Abdominoplasty, a commonly performed aesthetic procedure, is considered to have an increased risk of venous thromboembolism (VTE) events. At present, routine VTE chemoprophylaxis following abdominoplasty remains controversial. OBJECTIVES: This study evaluates the authors' experience with rivaroxaban, an oral Factor Xa inhibitor, for VTE prophylaxis in abdominoplasty patients. METHODS: A retrospective case series was conducted. All patients who underwent abdominoplasty and received rivaroxaban were included. The prophylactic dose was 10 mg daily for 7 days, beginning 12 hours postoperatively. Patient demographics, comorbidities, and type of surgery were recorded. The primary outcome measured was hematologic complication, including VTE, hematoma requiring operative evacuation, and need for blood transfusion. RESULTS: From September 2012 until July 2014, 132 patients (122 women and 10 men) underwent abdominoplasty surgery and received rivaroxaban postoperatively. Mean patient age was 43.7 years, and mean body mass index was 27.1. One hundred twenty-five patients also underwent abdominal muscle plication. Eleven patients underwent a fleur de lis vertical skin resection component. One hundred patients underwent concomitant abdominal liposuction, while 79 patients also had back liposuction. Only 1 patient had a symptomatic VTE event. Three patients had a hematoma requiring operative evacuation, and all went on to heal without sequelae. Two patients received a blood transfusion for anemia during their course of rivaroxaban. CONCLUSIONS: Oral rivaroxaban administration for chemoprophylaxis in abdominoplasty patients is safe, with low rates of symptomatic VTE and hematoma formation. The authors continue routine use of the medication for patients at increased risk for VTE events. LEVEL OF EVIDENCE 4: Risk

Chest Wall Resection for Adult Soft Tissue Sarcomas and Chondrosarcomas: Analysis of Prognostic Factors

Background: Wide resection with tumor-free margins is necessary in soft-tissue sarcomas to minimize local recurrence and to contribute to long-term survival. Information about treatment outcome and prognostic factors of adult sarcoma requiring chest wall resection (CWR) is limited. Methods: Sixty consecutive patients were retrospectively studied for overall survival (OS), local recurrence-free survival (LRFS), and disease-free survival (DFS). Twenty-one prognostic factors regarding survival were analyzed by univariate analysis using the Kaplan-Meier method and the log-rank test. Results: With a median survival of 2.5 years, the OS was 46% (33%) at 5 (10) years. The LRFS was 64% at 5 and 10 years, and the DFS was 30% and 25% at 5 and 10 years. At the end of the study period, 26 patients (43%) were alive, of which 20 patients (33%) had no evidence of disease and 40 patients (67%) had no chest wall recurrence. In the group of 9 patients with a radiation-induced soft-tissue sarcoma, the median survival was 8 months. Favorable outcome in univariate analysis in OS and LRFS applied for the low-grade sarcoma, bone invasion, and sternal resection. For OS only, age below 60 years and no radiotherapy were significant factors contributing to an improved survival. CWR was considered radical (R0) at the pathological examination in 43 patients. There were 52 patients with an uneventful recovery. There was one postoperative death. Conclusions: CWR for soft-tissue sarcoma is a safe surgical procedure with low morbidity and a mortality rate of less than 1%. With proper patient selection acceptable survival can be reached in a large group of patients. Care must be given to patients with radiation-induced soft-tissue sarcoma who have a significantly worse prognosis

Wind power production and electricity price volatility : an empirical study of the effect of increased wind power production on electricity price volatility in Norway

As renewable energy sources are gaining increasing importance on the global electricity scene, the importance of understanding their implications increases accordingly. This thesis aims to increase electricity market participants’ understanding of how the introduction of intermittent renewables in the energy mix will affect electricity price dynamics. Specifically, we examine whether wind power production has an effect on electricity price volatility in Norway. By doing so, we provide research on an unexamined market, which is particularly interesting due to its hydro-reliance and wind power potential. In our analysis, based on electricity price data from 2013 to 2019, we have found that there is a significant positive relationship between wind power production and intraweekly electricity price volatility in Norway. This finding has implications for Norwegian electricity consumers and producers, as increased price volatility creates both challenges and opportunities. Increased price volatility encourages investment in flexible supply and consumption, and we argue that such an investment may offset the disadvantages of the uncertainty associated with price fluctuations. In the analysis of wind power’s effect on intra-daily volatility, however, we do not find an equivalent significance. Thus this finding provides interesting opportunities for future research as global investments in wind power continue to increase.nhhma

«Sårbarhet kan jo være så mye»: En kvalitativ studie om hvordan seks kroppsøvingslærere forstår fenomenet sårbarhet og hvordan de tilrettelegger kroppsøvingsundervisningen.

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