4,511 research outputs found
Interference, reduced action, and trajectories
Instead of investigating the interference between two stationary, rectilinear
wave functions in a trajectory representation by examining the two rectilinear
wave functions individually, we examine a dichromatic wave function that is
synthesized from the two interfering wave functions. The physics of
interference is contained in the reduced action for the dichromatic wave
function. As this reduced action is a generator of the motion for the
dichromatic wave function, it determines the dichromatic wave function's
trajectory. The quantum effective mass renders insight into the behavior of the
trajectory. The trajectory in turn renders insight into quantum nonlocality.Comment: 12 pages text, 5 figures. Typos corrected. Author's final submission.
A companion paper to "Welcher Weg? A trajectory representation of a quantum
Young's diffraction experiment", quant-ph/0605121. Keywords: interference,
nonlocality, trajectory representation, entanglement, dwell time, determinis
The high energy limit of the trajectory representation of quantum mechanics
The trajectory representation in the high energy limit (Bohr correspondence
principle) manifests a residual indeterminacy. This indeterminacy is compared
to the indeterminacy found in the classical limit (Planck's constant to 0)
[Int. J. Mod. Phys. A 15, 1363 (2000)] for particles in the classically allowed
region, the classically forbiden region, and near the WKB turning point. The
differences between Bohr's and Planck's principles for the trajectory
representation are compared with the differences between these correspondence
principles for the wave representation. The trajectory representation in the
high energy limit is shown to go to neither classical nor statistical
mechanics. The residual indeterminacy is contrasted to Heisenberg uncertainty.
The relationship between indeterminacy and 't Hooft's information loss and
equivalence classes is investigated.Comment: 12 pages of LaTeX. No figures. Incorporated into the "Proceedings of
the Seventh International Wigner Symposium" (ed. M. E. Noz), 24-29 August
2001, U. of Maryland. Proceedings available at
http://www.physics.umd.edu/robo
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âJugglersâ, âcopersâ and âstrugglersâ: academicsâ perceptions of being a head of department in a post-1992 UK university and how it influences their future careers
This study investigates the experiences of academics who became department heads in a post-1992 UK university and explores the influence that being in the position has on their planned future academic career. Drawing on life history interviews undertaken with 17 male and female heads of department, the paper constitutes an in-depth study of their careers in the same university. The findings suggest that academics who become department heads not only need the capacity to assume a range of personal and professional identities, but need flexibility to regularly adopt and switch between them. Whether individuals can successfully balance and manage such multiple identities, or whether they experience major conflicts within or between them, greatly affects their experiences of being a head of department and seems to influence their subsequent career decisions. The paper concludes by proposing a conceptual framework and typology to interpret the career trajectories of academics that became department heads in the case university
Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans.
BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechanisms by which they impact individual susceptibility to proteotoxicity are still largely unknown.
RESULTS: We have previously shown that natural variation modifies polyglutamine (polyQ) aggregation phenotypes in C. elegans muscle cells. Here, we find that a genomic locus from C. elegans wild isolate DR1350 causes two genetically separable aggregation phenotypes, without changing the basal activity of muscle proteostasis pathways known to affect polyQ aggregation. We find that the increased aggregation phenotype was due to regulatory variants in the gene encoding a conserved autophagy protein ATG-5. The atg-5 gene itself conferred dosage-dependent enhancement of aggregation, with the DR1350-derived allele behaving as hypermorph. Surprisingly, increased aggregation in animals carrying the modifier locus was accompanied by enhanced autophagy activation in response to activating treatment. Because autophagy is expected to clear, not increase, protein aggregates, we activated autophagy in three different polyQ models and found a striking tissue-dependent effect: activation of autophagy decreased polyQ aggregation in neurons and intestine, but increased it in the muscle cells.
CONCLUSIONS: Our data show that cryptic natural variants in genes encoding proteostasis components, although not causing detectable phenotypes in wild-type individuals, can have profound effects on aggregation-prone proteins. Clinical applications of autophagy activators for aggregation diseases may need to consider the unexpected divergent effects of autophagy in different cell types
Caddisflies (Trichoptera) of Wildcat Creek, Pickens County, South Carolina
Sixty-two species of caddisflies (Trichoptera) were identified from collections make from Wildcat Creek over a period of 33 years. A new distributional record for South Carolina was obtained for Diplectrona metaqui. Eight species, Polycentropus carlsoni, Wormaldia thyria, Neotrichia collata, Stactobiella delira, Neophylax atlanta, Goera fuscula, Pseudogoera singularis, and Agarodes griseus, are considered to be threatened in South Carolina
The Equivalence Postulate of Quantum Mechanics
The Equivalence Principle (EP), stating that all physical systems are
connected by a coordinate transformation to the free one with vanishing energy,
univocally leads to the Quantum Stationary HJ Equation (QSHJE). Trajectories
depend on the Planck length through hidden variables which arise as initial
conditions. The formulation has manifest p-q duality, a consequence of the
involutive nature of the Legendre transform and of its recently observed
relation with second-order linear differential equations. This reflects in an
intrinsic psi^D-psi duality between linearly independent solutions of the
Schroedinger equation. Unlike Bohm's theory, there is a non-trivial action even
for bound states. No use of any axiomatic interpretation of the wave-function
is made. Tunnelling is a direct consequence of the quantum potential which
differs from the usual one and plays the role of particle's self-energy. The
QSHJE is defined only if the ratio psi^D/psi is a local self-homeomorphism of
the extended real line. This is an important feature as the L^2 condition,
which in the usual formulation is a consequence of the axiomatic interpretation
of the wave-function, directly follows as a basic theorem which only uses the
geometrical gluing conditions of psi^D/psi at q=\pm\infty as implied by the EP.
As a result, the EP itself implies a dynamical equation that does not require
any further assumption and reproduces both tunnelling and energy quantization.
Several features of the formulation show how the Copenhagen interpretation
hides the underlying nature of QM. Finally, the non-stationary higher
dimensional quantum HJ equation and the relativistic extension are derived.Comment: 1+3+140 pages, LaTeX. Invariance of the wave-function under the
action of SL(2,R) subgroups acting on the reduced action explicitly reveals
that the wave-function describes only equivalence classes of Planck length
deterministic physics. New derivation of the Schwarzian derivative from the
cocycle condition. "Legendre brackets" introduced to further make "Legendre
duality" manifest. Introduction now contains examples and provides a short
pedagogical review. Clarifications, conclusions, ackn. and references adde
Advanced tracking systems design and analysis
The results of an assessment of several types of high-accuracy tracking systems proposed to track the spacecraft in the National Aeronautics and Space Administration (NASA) Advanced Tracking and Data Relay Satellite System (ATDRSS) are summarized. Tracking systems based on the use of interferometry and ranging are investigated. For each system, the top-level system design and operations concept are provided. A comparative system assessment is presented in terms of orbit determination performance, ATDRSS impacts, life-cycle cost, and technological risk
Blocked All-Pairs Shortest Paths Algorithm on Intel Xeon Phi KNL Processor: A Case Study
Manycores are consolidating in HPC community as a way of improving
performance while keeping power efficiency. Knights Landing is the recently
released second generation of Intel Xeon Phi architecture. While optimizing
applications on CPUs, GPUs and first Xeon Phi's has been largely studied in the
last years, the new features in Knights Landing processors require the revision
of programming and optimization techniques for these devices. In this work, we
selected the Floyd-Warshall algorithm as a representative case study of graph
and memory-bound applications. Starting from the default serial version, we
show how data, thread and compiler level optimizations help the parallel
implementation to reach 338 GFLOPS.Comment: Computer Science - CACIC 2017. Springer Communications in Computer
and Information Science, vol 79
Aquatic Insects of Upper Three Runs Creek, Savannah River Plant, South Carolina. Part IV: Caddisflies (Trichoptera) of the Lower Reaches
Ninety-three species of caddisflies, representing 14 families, were identified from collections obtained from two localities on Upper Three Runs Creek, Savannah River Site, Aiken County, South Carolina. Collections of adult caddisflies were made biweekly over a 1-yr period with ultraviolet light traps. The similarity index, Jaccard\u27s Coefficient of Communities, showed that the two sites were over 78% similar with 73 species in common. Three species, Oxyethira setosa Denning, Triaenodes smithi Ross, and Nyctiophylax serratus Lago & Harris, are new distributional records for South Carolina. Two species of Triaenodes are new to science. Other species, which were considered to be endemic to the Upper Three Runs Creek drainage, rare outside of the drainage, or of limited distribution, included Cheumatopsyche richardsoni Gordon, Oxyethira dunbartonensis Kelley, Protoptila morettii Morse, Hydrophysche elissoma Ross, Triaenodes ochraceus (Betten and Mosely), Neotrichia falca Ross, Oecetis morsei Bueno-Soria, and Pycnopsyche virginica (Banks)
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