985 research outputs found
Refractive effects in the scattering of loosely bound nuclei
A study of the interaction of loosely bound nuclei 6,7Li at 9 and 19 AMeV
with light targets has been undertaken. With the determination of unambiguous
optical potentials in mind, elastic data for four projectile-target
combinations and one neutron transfer reaction 13C(7Li,8Li)12C have been
measured on a large angular range. The kinematical regime encompasses a region
where the mean field (optical potential) has a marked variation with mass and
energy, but turns out to be sufficiently surface transparent to allow strong
refractive effects to be manifested in elastic scattering data at intermediate
angles. The identified exotic feature, a "plateau" in the angular distributions
at intermediate angles, is fully confirmed in four reaction channels and
interpreted as a pre-rainbow oscillation resulting from the interference of the
barrier and internal barrier farside scattering subamplitudes.Comment: 19 pages, 14 figures, 3 tables to submit to Phys. Rev.
Probing molecular free energy landscapes by periodic loading
Single molecule pulling experiments provide information about interactions in
biomolecules that cannot be obtained by any other method. However, the
reconstruction of the molecule's free energy profile from the experimental data
is still a challenge, in particular for the unstable barrier regions. We
propose a new method for obtaining the full profile by introducing a periodic
ramp and using Jarzynski's identity for obtaining equilibrium quantities from
non-equilibrium data. Our simulated experiments show that this method delivers
significant more accurate data than previous methods, under the constraint of
equal experimental effort.Comment: 4 pages, 3 figure
Sydnone C-4 heteroarylation with an indolizine ring via Chichibabin indolizine synthesis
The synthesis of sydnones heteroarylated at C-4 with an indolizine was achieved by Chichibabin (Tschitschibabin) indolizine synthesis starting from the corresponding sydnone-N-pyridinium bromides. The latter compounds were also transformed to sydnone-indolizines connected through a keto group at the C-4 position by refluxing them in 1,2-epoxybutane with an activated alkyne. The structures of the new compounds were assigned by FTIR, NMR spectroscopy and X-ray analysis
Escape from a metastable well under a time-ramped force
Thermally activated escape of an over-damped particle from a metastable well
under the action of a time-ramped force is studied. We express the mean first
passage time (MFPT) as the solution to a partial differential equation, which
we solve numerically for a model case. We discuss two approximations of the
MFPT, one of which works remarkably well over a wide range of loading rates,
while the second is easy to calculate and can provide a valuable first
estimate.Comment: 9 pages, including 2 figure
1-Allyl-3,3-diphenylÂindolin-2-one
In the title compound, C23H19NO, the oxindole residue is essentially planar and is almost perpendicular to the phenyl rings [dihedral angles = 72.1 (6) and 77.6 (6)°]. The molÂecular packing is stabilized by C—H⋯O hydrogen bonds and C—H⋯N interÂactions
Australian Opportunities in a Circular Economy for Metals: Findings of the Wealth from Waste Cluster
Electron Microscopy Of Wood Of Callixylon And Cordaites
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141638/1/ajb210693.pd
Ligand-Receptor Interactions
The formation and dissociation of specific noncovalent interactions between a
variety of macromolecules play a crucial role in the function of biological
systems. During the last few years, three main lines of research led to a
dramatic improvement of our understanding of these important phenomena. First,
combination of genetic engineering and X ray cristallography made available a
simultaneous knowledg of the precise structure and affinity of series or
related ligand-receptor systems differing by a few well-defined atoms. Second,
improvement of computer power and simulation techniques allowed extended
exploration of the interaction of realistic macromolecules. Third, simultaneous
development of a variety of techniques based on atomic force microscopy,
hydrodynamic flow, biomembrane probes, optical tweezers, magnetic fields or
flexible transducers yielded direct experimental information of the behavior of
single ligand receptor bonds. At the same time, investigation of well defined
cellular models raised the interest of biologists to the kinetic and mechanical
properties of cell membrane receptors. The aim of this review is to give a
description of these advances that benefitted from a largely multidisciplinar
approach
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